ID   PSPC_MOUSE              Reviewed;         193 AA.
AC   P21841;
DT   01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1991, sequence version 1.
DT   25-MAY-2022, entry version 141.
DE   RecName: Full=Pulmonary surfactant-associated protein C;
DE            Short=SP-C;
DE   AltName: Full=Pulmonary surfactant-associated proteolipid SPL(Val);
DE   AltName: Full=SP5;
DE   Flags: Precursor;
GN   Name=Sftpc; Synonyms=Sftp2;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2254341; DOI=10.1016/s0021-9258(18)45836-x;
RA   Glasser S.W., Korehagen T.R., Bruno M.D., Dey C., Whitsett J.A.;
RT   "Structure and expression of the pulmonary surfactant protein SP-C gene in
RT   the mouse.";
RL   J. Biol. Chem. 265:21986-21991(1990).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Lung;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: Pulmonary surfactant associated proteins promote alveolar
CC       stability by lowering the surface tension at the air-liquid interface
CC       in the peripheral air spaces.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, surface film.
CC   -!- MISCELLANEOUS: Pulmonary surfactant consists of 90% lipid and 10%
CC       protein. There are 4 surfactant-associated proteins: 2 collagenous,
CC       carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small
CC       hydrophobic proteins (SP-B and SP-C).
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DR   EMBL; M38314; AAA40010.1; -; Genomic_DNA.
DR   CCDS; CCDS27254.1; -.
DR   PIR; A36534; A36534.
DR   AlphaFoldDB; P21841; -.
DR   SMR; P21841; -.
DR   STRING; 10090.ENSMUSP00000022692; -.
DR   iPTMnet; P21841; -.
DR   PhosphoSitePlus; P21841; -.
DR   MaxQB; P21841; -.
DR   PaxDb; P21841; -.
DR   PRIDE; P21841; -.
DR   ProteomicsDB; 302001; -.
DR   MGI; MGI:109517; Sftpc.
DR   eggNOG; ENOG502S6QH; Eukaryota.
DR   InParanoid; P21841; -.
DR   PhylomeDB; P21841; -.
DR   Reactome; R-MMU-5683826; Surfactant metabolism.
DR   ChiTaRS; Sftpc; mouse.
DR   PRO; PR:P21841; -.
DR   Proteomes; UP000000589; Unplaced.
DR   RNAct; P21841; protein.
DR   GO; GO:0097208; C:alveolar lamellar body; ISO:MGI.
DR   GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR   GO; GO:0005576; C:extracellular region; IDA:MGI.
DR   GO; GO:0005615; C:extracellular space; ISO:MGI.
DR   GO; GO:0005771; C:multivesicular body; ISO:MGI.
DR   GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR   GO; GO:0007585; P:respiratory gaseous exchange by respiratory system; IEA:UniProtKB-KW.
DR   InterPro; IPR007084; BRICHOS_dom.
DR   InterPro; IPR001729; SP-C.
DR   InterPro; IPR018051; SP-C_palmitoylation_site.
DR   InterPro; IPR015091; Surfactant_protein_propep.
DR   PANTHER; PTHR10800; PTHR10800; 1.
DR   Pfam; PF04089; BRICHOS; 1.
DR   Pfam; PF08999; SP_C-Propep; 1.
DR   SMART; SM01039; BRICHOS; 1.
DR   SMART; SM00019; SF_P; 1.
DR   PROSITE; PS50869; BRICHOS; 1.
DR   PROSITE; PS00341; SURFACT_PALMITOYL; 1.
PE   1: Evidence at protein level;
KW   Disulfide bond; Gaseous exchange; Lipoprotein; Palmitate;
KW   Reference proteome; Secreted; Surface film.
FT   PROPEP          1..23
FT                   /id="PRO_0000033483"
FT   CHAIN           24..58
FT                   /note="Pulmonary surfactant-associated protein C"
FT                   /id="PRO_0000033484"
FT   PROPEP          59..193
FT                   /id="PRO_0000033485"
FT   DOMAIN          94..193
FT                   /note="BRICHOS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00255"
FT   REGION          147..170
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           28
FT                   /note="S-palmitoyl cysteine"
FT                   /evidence="ECO:0000250"
FT   LIPID           29
FT                   /note="S-palmitoyl cysteine"
FT                   /evidence="ECO:0000250"
FT   DISULFID        121..185
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   193 AA;  21055 MW;  10CCD91889AC8301 CRC64;
     MDMSSKEVLM ESPPDYSAGP RSQFRIPCCP VHLKRLLIVV VVVVLVVVVI VGALLMGLHM
     SQKHTEMVLE MSIGAPETQK RLAPSERADT IATFSIGSTG IVVYDYQRLL TAYKPAPGTY
     CYIMKMAPES IPSLEAFARK LQNFRAKPST PTSKLGQEEG HDTGSESDSS GRDLAFLGLA
     VSTLCGELPL YYI