ID   PSPC_NEOVI              Reviewed;         190 AA.
AC   P35245;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Pulmonary surfactant-associated protein C;
DE            Short=SP-C;
DE   Flags: Precursor;
GN   Name=SFTPC; Synonyms=SFTP2;
OS   Neovison vison (American mink) (Mustela vison).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Mustelidae; Mustelinae;
OC   Neogale.
OX   NCBI_TaxID=452646;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Lung;
RA   Christensen J., Belousov J., Storgaard T., Aasted B., Alexandersen S.;
RT   "Nucleotide and deduced amino acid sequence of the hydrophobic surfactant
RT   protein SP-C from mink.";
RL   Submitted (DEC-1992) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Pulmonary surfactant associated proteins promote alveolar
CC       stability by lowering the surface tension at the air-liquid interface
CC       in the peripheral air spaces.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, surface film.
CC   -!- MISCELLANEOUS: Pulmonary surfactant consists of 90% lipid and 10%
CC       protein. There are 4 surfactant-associated proteins: 2 collagenous,
CC       carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small
CC       hydrophobic proteins (SP-B and SP-C).
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DR   EMBL; Z19516; CAA79577.1; -; mRNA.
DR   PIR; S31490; S31490.
DR   AlphaFoldDB; P35245; -.
DR   SMR; P35245; -.
DR   Ensembl; ENSNVIT00000033360; ENSNVIP00000028785; ENSNVIG00000022200.
DR   GeneTree; ENSGT00390000017162; -.
DR   Proteomes; UP000694425; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-SubCell.
DR   GO; GO:0007585; P:respiratory gaseous exchange by respiratory system; IEA:UniProtKB-KW.
DR   InterPro; IPR007084; BRICHOS_dom.
DR   InterPro; IPR001729; SP-C.
DR   InterPro; IPR015091; Surfactant_protein_propep.
DR   PANTHER; PTHR10800; PTHR10800; 1.
DR   Pfam; PF04089; BRICHOS; 1.
DR   Pfam; PF08999; SP_C-Propep; 1.
DR   SMART; SM01039; BRICHOS; 1.
DR   SMART; SM00019; SF_P; 1.
DR   PROSITE; PS50869; BRICHOS; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Gaseous exchange; Lipoprotein; Palmitate;
KW   Reference proteome; Secreted; Surface film.
FT   PROPEP          1..23
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000033486"
FT   CHAIN           24..58
FT                   /note="Pulmonary surfactant-associated protein C"
FT                   /id="PRO_0000033487"
FT   PROPEP          59..190
FT                   /id="PRO_0000033488"
FT   DOMAIN          94..190
FT                   /note="BRICHOS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00255"
FT   LIPID           28
FT                   /note="S-palmitoyl cysteine"
FT                   /evidence="ECO:0000250"
FT   DISULFID        121..182
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   190 AA;  20431 MW;  FFAC262747A11E27 CRC64;
     MDVGSKEVLI ENPPDYSAAP QGRFGLPCFP SSLKRLLIIV VVIVLVVVVI VGALLMGLHM
     SQKHTEMVLE MSLGGPEAQQ RLALQERAGT TATFSIGSTG IVVYDYQRLL IAYKPAPGTC
     CYIMKMAPEN IPSLEALTRK FQNFQVKPAV STSKLGQEEG HNAGSASPGD LDFLGTTVST
     LCGEVPLYYI