ID   PSPC_PIG                Reviewed;          35 AA.
AC   P15785;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1990, sequence version 1.
DT   25-MAY-2022, entry version 113.
DE   RecName: Full=Pulmonary surfactant-associated protein C;
DE            Short=SP-C;
DE   AltName: Full=Pulmonary surfactant-associated proteolipid SPL(Val);
GN   Name=SFTPC; Synonyms=SFTP2;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=3408709; DOI=10.1021/bi00410a002;
RA   Johansson J., Curstedt T., Robertson B., Joernvall H.;
RT   "Size and structure of the hydrophobic low molecular weight surfactant-
RT   associated polypeptide.";
RL   Biochemistry 27:3544-3547(1988).
RN   [2]
RP   PALMITOYLATION AT CYS-5 AND CYS-6.
RX   PubMed=2326260; DOI=10.1073/pnas.87.8.2985;
RA   Curstedt T., Johansson J., Persson P., Eklund A., Robertson B.,
RA   Loewenadler B., Joernvall H.;
RT   "Hydrophobic surfactant-associated polypeptides: SP-C is a lipopeptide with
RT   two palmitoylated cysteine residues, whereas SP-B lacks covalently linked
RT   fatty acyl groups.";
RL   Proc. Natl. Acad. Sci. U.S.A. 87:2985-2989(1990).
RN   [3]
RP   STRUCTURE BY NMR.
RX   PubMed=8180229; DOI=10.1021/bi00185a042;
RA   Johansson J., Szyperski T., Curstedt T., Wuethrich K.;
RT   "The NMR structure of the pulmonary surfactant-associated polypeptide SP-C
RT   in an apolar solvent contains a valyl-rich alpha-helix.";
RL   Biochemistry 33:6015-6023(1994).
CC   -!- FUNCTION: Pulmonary surfactant associated proteins promote alveolar
CC       stability by lowering the surface tension at the air-liquid interface
CC       in the peripheral air spaces.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, surface film.
CC   -!- MISCELLANEOUS: Pulmonary surfactant consists of 90% lipid and 10%
CC       protein. There are 4 surfactant-associated proteins: 2 collagenous,
CC       carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small
CC       hydrophobic proteins (SP-B and SP-C).
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DR   PIR; A28640; LNPGC1.
DR   PDB; 1SPF; NMR; -; A=1-35.
DR   PDB; 5NDA; NMR; -; A=3-35.
DR   PDBsum; 1SPF; -.
DR   PDBsum; 5NDA; -.
DR   AlphaFoldDB; P15785; -.
DR   BMRB; P15785; -.
DR   SMR; P15785; -.
DR   STRING; 9823.ENSSSCP00000010269; -.
DR   SwissPalm; P15785; -.
DR   PaxDb; P15785; -.
DR   eggNOG; ENOG502S6QH; Eukaryota.
DR   HOGENOM; CLU_087015_0_0_1; -.
DR   EvolutionaryTrace; P15785; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   Genevisible; P15785; SS.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-SubCell.
DR   GO; GO:0007585; P:respiratory gaseous exchange by respiratory system; IEA:UniProtKB-KW.
DR   InterPro; IPR018051; SP-C_palmitoylation_site.
DR   InterPro; IPR015091; Surfactant_protein_propep.
DR   Pfam; PF08999; SP_C-Propep; 1.
DR   PROSITE; PS00341; SURFACT_PALMITOYL; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Direct protein sequencing; Gaseous exchange; Lipoprotein;
KW   Palmitate; Reference proteome; Secreted; Surface film.
FT   CHAIN           1..35
FT                   /note="Pulmonary surfactant-associated protein C"
FT                   /id="PRO_0000183015"
FT   LIPID           5
FT                   /note="S-palmitoyl cysteine"
FT                   /evidence="ECO:0000269|PubMed:2326260"
FT   LIPID           6
FT                   /note="S-palmitoyl cysteine"
FT                   /evidence="ECO:0000269|PubMed:2326260"
FT   STRAND          4..6
FT                   /evidence="ECO:0007829|PDB:1SPF"
FT   HELIX           9..33
FT                   /evidence="ECO:0007829|PDB:1SPF"
SQ   SEQUENCE   35 AA;  3710 MW;  C8A713AFF926F0FE CRC64;
     LRIPCCPVNL KRLLVVVVVV VLVVVVIVGA LLMGL