PSPC_RABIT
ID PSPC_RABIT Reviewed; 188 AA.
AC P22398;
DT 01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 3.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Pulmonary surfactant-associated protein C;
DE Short=SP-C;
DE AltName: Full=Pulmonary surfactant-associated proteolipid SPL(Val);
DE Flags: Precursor;
GN Name=SFTPC; Synonyms=SFTP2;
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=New Zealand white; TISSUE=Lung;
RX PubMed=1643107; DOI=10.1016/0005-2760(92)90278-4;
RA Connelly I., Possmayer F.;
RT "cDNA sequence and alternative mRNA splicing of surfactant-associated
RT protein C (SP-C) in rabbit lung.";
RL Biochim. Biophys. Acta 1127:199-207(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Lung;
RX PubMed=1335697; DOI=10.1152/ajplung.1992.263.6.l634;
RA Boggaram V., Margana R.K.;
RT "Rabbit surfactant protein C: cDNA cloning and regulation of alternatively
RT spliced surfactant protein C mRNAs.";
RL Am. J. Physiol. 263:L634-L644(1992).
RN [3]
RP NUCLEOTIDE SEQUENCE.
RA Margana R.K., Boggaram V.;
RT "Cloning, sequence and characterization of the rabbit surfactant protein C
RT gene.";
RL Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 24-188.
RC TISSUE=Lung;
RX PubMed=1468410; DOI=10.3109/01902149209031707;
RA Durham P.L., Nanthakumar E.J., Snyder J.M.;
RT "Developmental regulation of surfactant-associated proteins in rabbit fetal
RT lung in vivo.";
RL Exp. Lung Res. 18:775-793(1992).
RN [5]
RP PROTEIN SEQUENCE OF 24-37, AND PALMITOYLATION AT CYS-28 AND CYS-29.
RX PubMed=2015882; DOI=10.1016/0014-5793(91)80373-b;
RA Johansson J., Persson P., Loewenadler B., Robertson B., Joernvall H.,
RA Curstedt T.;
RT "Canine hydrophobic surfactant polypeptide SP-C. A lipopeptide with one
RT thioester-linked palmitoyl group.";
RL FEBS Lett. 281:119-122(1991).
CC -!- FUNCTION: Pulmonary surfactant associated proteins promote alveolar
CC stability by lowering the surface tension at the air-liquid interface
CC in the peripheral air spaces.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, surface film.
CC -!- MISCELLANEOUS: Pulmonary surfactant consists of 90% lipid and 10%
CC protein. There are 4 surfactant-associated proteins: 2 collagenous,
CC carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small
CC hydrophobic proteins (SP-B and SP-C).
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA46204.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; X65078; CAA46204.1; ALT_INIT; mRNA.
DR EMBL; S51983; AAB24761.1; -; mRNA.
DR EMBL; AF037445; AAC18032.1; -; Genomic_DNA.
DR EMBL; S51597; AAB24762.1; -; mRNA.
DR EMBL; S51098; AAB24576.2; -; mRNA.
DR PIR; A56766; LNRBC1.
DR RefSeq; NP_001075791.1; NM_001082322.1.
DR AlphaFoldDB; P22398; -.
DR SMR; P22398; -.
DR STRING; 9986.ENSOCUP00000001748; -.
DR SwissPalm; P22398; -.
DR PRIDE; P22398; -.
DR GeneID; 100009162; -.
DR KEGG; ocu:100009162; -.
DR CTD; 6440; -.
DR eggNOG; ENOG502S6QH; Eukaryota.
DR InParanoid; P22398; -.
DR OrthoDB; 1323673at2759; -.
DR Proteomes; UP000001811; Unplaced.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-SubCell.
DR GO; GO:0007585; P:respiratory gaseous exchange by respiratory system; IEA:UniProtKB-KW.
DR InterPro; IPR007084; BRICHOS_dom.
DR InterPro; IPR001729; SP-C.
DR InterPro; IPR018051; SP-C_palmitoylation_site.
DR InterPro; IPR015091; Surfactant_protein_propep.
DR PANTHER; PTHR10800; PTHR10800; 1.
DR Pfam; PF04089; BRICHOS; 1.
DR Pfam; PF08999; SP_C-Propep; 1.
DR SMART; SM01039; BRICHOS; 1.
DR SMART; SM00019; SF_P; 1.
DR PROSITE; PS50869; BRICHOS; 1.
DR PROSITE; PS00341; SURFACT_PALMITOYL; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Disulfide bond; Gaseous exchange; Lipoprotein;
KW Palmitate; Reference proteome; Secreted; Surface film.
FT PROPEP 1..23
FT /evidence="ECO:0000269|PubMed:2015882"
FT /id="PRO_0000033489"
FT CHAIN 24..58
FT /note="Pulmonary surfactant-associated protein C"
FT /id="PRO_0000033490"
FT PROPEP 59..188
FT /id="PRO_0000033491"
FT DOMAIN 94..188
FT /note="BRICHOS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00255"
FT REGION 144..164
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 28
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000269|PubMed:2015882"
FT LIPID 29
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000269|PubMed:2015882"
FT DISULFID 121..180
FT /evidence="ECO:0000250"
FT CONFLICT 115
FT /note="P -> PP (in Ref. 2; AAB24761/AAB24762)"
FT /evidence="ECO:0000305"
FT CONFLICT 153
FT /note="G -> A (in Ref. 4; AAB24576)"
FT /evidence="ECO:0000305"
FT CONFLICT 159
FT /note="A -> G (in Ref. 4; AAB24576)"
FT /evidence="ECO:0000305"
FT CONFLICT 161
FT /note="G -> R (in Ref. 1; CAA46204)"
FT /evidence="ECO:0000305"
FT CONFLICT 186
FT /note="I -> Y (in Ref. 4; AAB24576)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 188 AA; 19836 MW; F622EEA933786F78 CRC64;
MDMGSKEALM ESPPDYSAAP RGRFGIPCCP VHLKRLLIVV VVVVLVVVVI VGALLMGLHM
SQKHTEMVLE MSIGAPEVQQ RLALSEWAGT TATFPIGSTG IVTCDYQRLL IAYKPAPGTC
CYLMKMAPDS IPSLEALARK FQANPAEPPT QRGQDKGPAA GPASSGGELA FLGAAVSTLC
GEVPLIYI
