PSPC_RAT
ID PSPC_RAT Reviewed; 194 AA.
AC P11685; Q52MA6;
DT 01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1989, sequence version 1.
DT 25-MAY-2022, entry version 148.
DE RecName: Full=Pulmonary surfactant-associated protein C;
DE Short=SP-C;
DE AltName: Full=Pulmonary surfactant-associated proteolipid SPL(Val);
DE Flags: Precursor;
GN Name=Sftpc; Synonyms=Sftp2;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley; TISSUE=Lung;
RX PubMed=2706272; DOI=10.1016/0167-4838(89)90040-x;
RA Fisher J.H., Shannon J.M., Hatmann T., Mason R.J.;
RT "Nucleotide and deduced amino acid sequence of the hydrophobic surfactant
RT protein SP-C from rat: expression in alveolar type II cells and homology
RT with SP-C from other species.";
RL Biochim. Biophys. Acta 995:225-230(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Liver;
RA Rishi A.K., Gulamhussein A.I., Albanese S., Williams M.C., Brody J.S.;
RL Submitted (DEC-1994) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Pulmonary surfactant associated proteins promote alveolar
CC stability by lowering the surface tension at the air-liquid interface
CC in the peripheral air spaces.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, surface film.
CC -!- MISCELLANEOUS: Pulmonary surfactant consists of 90% lipid and 10%
CC protein. There are 4 surfactant-associated proteins: 2 collagenous,
CC carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small
CC hydrophobic proteins (SP-B and SP-C).
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DR EMBL; X14221; CAA32440.1; -; mRNA.
DR EMBL; U07796; AAA92788.1; -; Genomic_DNA.
DR EMBL; BC072693; AAH72693.1; -; mRNA.
DR PIR; S03994; LNRTC.
DR RefSeq; NP_059038.1; NM_017342.2.
DR AlphaFoldDB; P11685; -.
DR SMR; P11685; -.
DR STRING; 10116.ENSRNOP00000015032; -.
DR PaxDb; P11685; -.
DR GeneID; 50683; -.
DR KEGG; rno:50683; -.
DR UCSC; RGD:3666; rat.
DR CTD; 6440; -.
DR RGD; 3666; Sftpc.
DR eggNOG; ENOG502S6QH; Eukaryota.
DR HOGENOM; CLU_087015_0_0_1; -.
DR InParanoid; P11685; -.
DR OrthoDB; 1323673at2759; -.
DR PhylomeDB; P11685; -.
DR TreeFam; TF337317; -.
DR Reactome; R-RNO-5683826; Surfactant metabolism.
DR PRO; PR:P11685; -.
DR Proteomes; UP000002494; Unplaced.
DR Genevisible; P11685; RN.
DR GO; GO:0097208; C:alveolar lamellar body; IDA:RGD.
DR GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR GO; GO:0005576; C:extracellular region; ISO:RGD.
DR GO; GO:0005615; C:extracellular space; IDA:RGD.
DR GO; GO:0005771; C:multivesicular body; IDA:RGD.
DR GO; GO:0042802; F:identical protein binding; IPI:RGD.
DR GO; GO:0071260; P:cellular response to mechanical stimulus; IEP:RGD.
DR GO; GO:0071732; P:cellular response to nitric oxide; IEP:RGD.
DR GO; GO:0007623; P:circadian rhythm; IEP:RGD.
DR GO; GO:0050828; P:regulation of liquid surface tension; TAS:RGD.
DR GO; GO:0007585; P:respiratory gaseous exchange by respiratory system; IEA:UniProtKB-KW.
DR GO; GO:0051591; P:response to cAMP; IEP:RGD.
DR GO; GO:0051384; P:response to glucocorticoid; IEP:RGD.
DR GO; GO:0009749; P:response to glucose; IEP:RGD.
DR GO; GO:0070848; P:response to growth factor; IEP:RGD.
DR GO; GO:0009725; P:response to hormone; IEP:RGD.
DR GO; GO:0055093; P:response to hyperoxia; IEP:RGD.
DR GO; GO:0070741; P:response to interleukin-6; IEP:RGD.
DR GO; GO:0032496; P:response to lipopolysaccharide; IEP:RGD.
DR GO; GO:0010033; P:response to organic substance; IEP:RGD.
DR GO; GO:0032526; P:response to retinoic acid; IEP:RGD.
DR GO; GO:0033189; P:response to vitamin A; IEP:RGD.
DR InterPro; IPR007084; BRICHOS_dom.
DR InterPro; IPR001729; SP-C.
DR InterPro; IPR018051; SP-C_palmitoylation_site.
DR InterPro; IPR015091; Surfactant_protein_propep.
DR PANTHER; PTHR10800; PTHR10800; 1.
DR Pfam; PF04089; BRICHOS; 1.
DR Pfam; PF08999; SP_C-Propep; 1.
DR SMART; SM01039; BRICHOS; 1.
DR SMART; SM00019; SF_P; 1.
DR PROSITE; PS50869; BRICHOS; 1.
DR PROSITE; PS00341; SURFACT_PALMITOYL; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Gaseous exchange; Lipoprotein; Palmitate;
KW Reference proteome; Secreted; Surface film.
FT PROPEP 1..23
FT /evidence="ECO:0000250"
FT /id="PRO_0000033492"
FT CHAIN 24..58
FT /note="Pulmonary surfactant-associated protein C"
FT /id="PRO_0000033493"
FT PROPEP 59..194
FT /id="PRO_0000033494"
FT DOMAIN 95..194
FT /note="BRICHOS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00255"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 149..170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 28
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250"
FT LIPID 29
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250"
FT DISULFID 122..186
FT /evidence="ECO:0000250"
FT CONFLICT 188
FT /note="E -> V (in Ref. 2; AAA92788)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 194 AA; 21043 MW; 51A75A18E4C95E67 CRC64;
MDMGSKEVLM ESPPDYSTGP RSQFRIPCCP VHLKRLLIVV VVVVLVVVVI VGALLMGLHM
SQKHTEMVLE MSIGGAPETQ KRLALSEHTD TIATFSIGST GIVLYDYQRL LTAYKPAPGT
YCYIMKMAPE SIPSLEALAR KFKNFQAKSS TPTSKLGQEE GHSAGSDSDS SGRDLAFLGL
AVSTLCGELP LYYI
