ID   PSPHL_HUMAN             Reviewed;          72 AA.
AC   O15172; Q86U85;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Putative phosphoserine phosphatase-like protein;
DE   AltName: Full=L-3-phosphoserine-phosphatase homolog;
GN   Name=PSPHP1; Synonyms=CO9, PSPHL;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX   PubMed=9573387; DOI=10.1016/s0378-1119(98)00083-3;
RA   Planitzer S.A., Machl A.W., Rueckels M., Kubbies M.;
RT   "Identification of a novel c-DNA overexpressed in Fanconi's anemia
RT   fibroblasts partially homologous to a putative L-3-phosphoserine-
RT   phosphatase.";
RL   Gene 210:297-306(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA   Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA   Phelan M., Farmer A.;
RT   "Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
RL   Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- TISSUE SPECIFICITY: Highly expressed in FA (Fanconi's anemia) B-cells
CC       of complementation group A and Raji cells. Not expressed in B-cells of
CC       other FA complementation groups. {ECO:0000269|PubMed:9573387}.
CC   -!- SIMILARITY: Belongs to the HAD-like hydrolase superfamily. SerB family.
CC       {ECO:0000305}.
CC   -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
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DR   EMBL; AJ001612; CAA04865.1; -; mRNA.
DR   EMBL; BT006661; AAP35307.1; -; mRNA.
DR   AlphaFoldDB; O15172; -.
DR   SMR; O15172; -.
DR   BioMuta; HGNC:9578; -.
DR   MassIVE; O15172; -.
DR   MaxQB; O15172; -.
DR   PeptideAtlas; O15172; -.
DR   PRIDE; O15172; -.
DR   ProteomicsDB; 48494; -.
DR   CPTC; O15172; 3 antibodies.
DR   GeneCards; PSPHP1; -.
DR   HGNC; HGNC:9578; PSPHP1.
DR   MIM; 604239; gene.
DR   neXtProt; NX_O15172; -.
DR   InParanoid; O15172; -.
DR   Reactome; R-HSA-9707616; Heme signaling.
DR   ChiTaRS; PSPHP1; human.
DR   Pharos; O15172; Tdark.
DR   Proteomes; UP000005640; Unplaced.
DR   RNAct; O15172; protein.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005635; C:nuclear envelope; TAS:Reactome.
DR   GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
DR   GO; GO:0000287; F:magnesium ion binding; IBA:GO_Central.
DR   GO; GO:0016311; P:dephosphorylation; IBA:GO_Central.
DR   GO; GO:0006564; P:L-serine biosynthetic process; IBA:GO_Central.
PE   5: Uncertain;
KW   Reference proteome.
FT   CHAIN           1..72
FT                   /note="Putative phosphoserine phosphatase-like protein"
FT                   /id="PRO_0000318579"
FT   CONFLICT        57..72
FT                   /note="CFHWIWRKCDQATSQG -> RSLALSPGWSAMVQSRLTATSASWVQAILLPP
FT                   PPE (in Ref. 2; AAP35307)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   72 AA;  7804 MW;  78A192EE2EE88922 CRC64;
     MASASCSPGG ALASPEPGRK ILPRMISHSE LRKLFYSADA VCFDVDSTVI SEEGIGCFHW
     IWRKCDQATS QG