PSPN_HUMAN
ID PSPN_HUMAN Reviewed; 156 AA.
AC O60542;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Persephin;
DE Short=PSP;
DE Flags: Precursor;
GN Name=PSPN;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9491986; DOI=10.1016/s0896-6273(00)80453-5;
RA Milbrandt J., de Sauvage F.J., Fahrner T.J., Baloh R.H., Leitner M.L.,
RA Tansey M.G., Lampe P.A., Heuckeroth R.O., Kotzbauer P.T., Simburger K.S.,
RA Golden J.P., Davies J.A., Vejsada R., Kato A.C., Hynes M., Sherman D.,
RA Nishimura M., Wang L.-C., Vandlen R., Moffat B., Klein R.D., Poulsen K.,
RA Gray C., Garces A., Henderson C.E., Phillips H.S., Johnson E.M.;
RT "Persephin, a novel neurotrophic factor related to GDNF and neurturin.";
RL Neuron 20:245-253(1998).
CC -!- FUNCTION: Exhibits neurotrophic activity on mesencephalic dopaminergic
CC and motor neurons.
CC -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the TGF-beta family. GDNF subfamily.
CC {ECO:0000305}.
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DR EMBL; AF040962; AAC39640.1; -; mRNA.
DR CCDS; CCDS12164.1; -.
DR RefSeq; NP_004149.1; NM_004158.3.
DR AlphaFoldDB; O60542; -.
DR SMR; O60542; -.
DR BioGRID; 111607; 31.
DR STRING; 9606.ENSP00000245810; -.
DR iPTMnet; O60542; -.
DR PhosphoSitePlus; O60542; -.
DR BioMuta; PSPN; -.
DR MassIVE; O60542; -.
DR PaxDb; O60542; -.
DR PRIDE; O60542; -.
DR Antibodypedia; 42539; 217 antibodies from 26 providers.
DR DNASU; 5623; -.
DR Ensembl; ENST00000245810.2; ENSP00000245810.1; ENSG00000125650.5.
DR GeneID; 5623; -.
DR KEGG; hsa:5623; -.
DR MANE-Select; ENST00000245810.2; ENSP00000245810.1; NM_004158.5; NP_004149.1.
DR UCSC; uc010xja.2; human.
DR CTD; 5623; -.
DR DisGeNET; 5623; -.
DR GeneCards; PSPN; -.
DR HGNC; HGNC:9579; PSPN.
DR HPA; ENSG00000125650; Tissue enhanced (brain).
DR MIM; 602921; gene.
DR neXtProt; NX_O60542; -.
DR OpenTargets; ENSG00000125650; -.
DR PharmGKB; PA33930; -.
DR VEuPathDB; HostDB:ENSG00000125650; -.
DR eggNOG; ENOG502S9IE; Eukaryota.
DR GeneTree; ENSGT00950000182993; -.
DR HOGENOM; CLU_102221_2_0_1; -.
DR InParanoid; O60542; -.
DR OMA; TFRYCAG; -.
DR OrthoDB; 1373819at2759; -.
DR PhylomeDB; O60542; -.
DR TreeFam; TF332366; -.
DR PathwayCommons; O60542; -.
DR Reactome; R-HSA-419037; NCAM1 interactions.
DR Reactome; R-HSA-5673001; RAF/MAP kinase cascade.
DR Reactome; R-HSA-8853659; RET signaling.
DR SignaLink; O60542; -.
DR SIGNOR; O60542; -.
DR BioGRID-ORCS; 5623; 11 hits in 1069 CRISPR screens.
DR GenomeRNAi; 5623; -.
DR Pharos; O60542; Tbio.
DR PRO; PR:O60542; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; O60542; protein.
DR Bgee; ENSG00000125650; Expressed in tendon of biceps brachii and 98 other tissues.
DR ExpressionAtlas; O60542; baseline and differential.
DR Genevisible; O60542; HS.
DR GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0030116; F:glial cell-derived neurotrophic factor receptor binding; IEA:InterPro.
DR GO; GO:0008083; F:growth factor activity; IBA:GO_Central.
DR GO; GO:0030971; F:receptor tyrosine kinase binding; IEA:InterPro.
DR GO; GO:0005102; F:signaling receptor binding; TAS:ProtInc.
DR GO; GO:0007417; P:central nervous system development; TAS:ProtInc.
DR GO; GO:0007399; P:nervous system development; TAS:ProtInc.
DR Gene3D; 2.10.90.10; -; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR043401; GDNF_fam.
DR InterPro; IPR001839; TGF-b_C.
DR PANTHER; PTHR12173; PTHR12173; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; SSF57501; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Growth factor; Reference proteome; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..156
FT /note="Persephin"
FT /id="PRO_0000034014"
FT DISULFID 66..124
FT /evidence="ECO:0000250"
FT DISULFID 93..152
FT /evidence="ECO:0000250"
FT DISULFID 97..154
FT /evidence="ECO:0000250"
FT DISULFID 123
FT /note="Interchain"
FT /evidence="ECO:0000250"
SQ SEQUENCE 156 AA; 16600 MW; 6547751653A7044A CRC64;
MAVGKFLLGS LLLLSLQLGQ GWGPDARGVP VADGEFSSEQ VAKAGGTWLG THRPLARLRR
ALSGPCQLWS LTLSVAELGL GYASEEKVIF RYCAGSCPRG ARTQHGLALA RLQGQGRAHG
GPCCRPTRYT DVAFLDDRHR WQRLPQLSAA ACGCGG
