ID   PSPN_MOUSE              Reviewed;         156 AA.
AC   O70300;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   25-MAY-2022, entry version 115.
DE   RecName: Full=Persephin;
DE            Short=PSP;
DE   Flags: Precursor;
GN   Name=Pspn;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=129/SvJ;
RX   PubMed=9491986; DOI=10.1016/s0896-6273(00)80453-5;
RA   Milbrandt J., de Sauvage F.J., Fahrner T.J., Baloh R.H., Leitner M.L.,
RA   Tansey M.G., Lampe P.A., Heuckeroth R.O., Kotzbauer P.T., Simburger K.S.,
RA   Golden J.P., Davies J.A., Vejsada R., Kato A.C., Hynes M., Sherman D.,
RA   Nishimura M., Wang L.-C., Vandlen R., Moffat B., Klein R.D., Poulsen K.,
RA   Gray C., Garces A., Henderson C.E., Phillips H.S., Johnson E.M.;
RT   "Persephin, a novel neurotrophic factor related to GDNF and neurturin.";
RL   Neuron 20:245-253(1998).
CC   -!- FUNCTION: Exhibits neurotrophic activity on mesencephalic dopaminergic
CC       and motor neurons.
CC   -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the TGF-beta family. GDNF subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AF040960; AAC40057.1; -; mRNA.
DR   CCDS; CCDS28922.1; -.
DR   AlphaFoldDB; O70300; -.
DR   SMR; O70300; -.
DR   STRING; 10090.ENSMUSP00000002740; -.
DR   PhosphoSitePlus; O70300; -.
DR   PaxDb; O70300; -.
DR   PRIDE; O70300; -.
DR   MGI; MGI:1201684; Pspn.
DR   eggNOG; ENOG502S9IE; Eukaryota.
DR   InParanoid; O70300; -.
DR   PhylomeDB; O70300; -.
DR   Reactome; R-MMU-5673001; RAF/MAP kinase cascade.
DR   Reactome; R-MMU-8853659; RET signaling.
DR   PRO; PR:O70300; -.
DR   Proteomes; UP000000589; Unplaced.
DR   RNAct; O70300; protein.
DR   GO; GO:0005615; C:extracellular space; IDA:MGI.
DR   GO; GO:0030116; F:glial cell-derived neurotrophic factor receptor binding; IEA:InterPro.
DR   GO; GO:0008083; F:growth factor activity; IBA:GO_Central.
DR   GO; GO:0030971; F:receptor tyrosine kinase binding; IEA:InterPro.
DR   GO; GO:0005102; F:signaling receptor binding; TAS:MGI.
DR   GO; GO:0001658; P:branching involved in ureteric bud morphogenesis; IDA:MGI.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR043401; GDNF_fam.
DR   InterPro; IPR001839; TGF-b_C.
DR   PANTHER; PTHR12173; PTHR12173; 1.
DR   Pfam; PF00019; TGF_beta; 1.
DR   SUPFAM; SSF57501; SSF57501; 1.
DR   PROSITE; PS51362; TGF_BETA_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Growth factor; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..156
FT                   /note="Persephin"
FT                   /id="PRO_0000034015"
FT   DISULFID        66..124
FT                   /evidence="ECO:0000250"
FT   DISULFID        93..152
FT                   /evidence="ECO:0000250"
FT   DISULFID        97..154
FT                   /evidence="ECO:0000250"
FT   DISULFID        123
FT                   /note="Interchain"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   156 AA;  17031 MW;  7DC6DD98132E041B CRC64;
     MAAGRLRILC LLLLSLHPSL GWVLDLQEAS VADKLSFGKM AETRGTWTPH QGNNHVRLPR
     ALAGSCRLWS LTLPVAELGL GYASEEKVIF RYCAGSCPQE ARTQHSLVLA RLRGRGRAHG
     RPCCQPTSYA DVTFLDDQHH WQQLPQLSAA ACGCGG