ID   PSPN_RAT                Reviewed;         156 AA.
AC   O70301;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Persephin;
DE            Short=PSP;
DE   Flags: Precursor;
GN   Name=Pspn;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=9491986; DOI=10.1016/s0896-6273(00)80453-5;
RA   Milbrandt J., de Sauvage F.J., Fahrner T.J., Baloh R.H., Leitner M.L.,
RA   Tansey M.G., Lampe P.A., Heuckeroth R.O., Kotzbauer P.T., Simburger K.S.,
RA   Golden J.P., Davies J.A., Vejsada R., Kato A.C., Hynes M., Sherman D.,
RA   Nishimura M., Wang L.-C., Vandlen R., Moffat B., Klein R.D., Poulsen K.,
RA   Gray C., Garces A., Henderson C.E., Phillips H.S., Johnson E.M.;
RT   "Persephin, a novel neurotrophic factor related to GDNF and neurturin.";
RL   Neuron 20:245-253(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-78.
RC   STRAIN=Sprague-Dawley; TISSUE=Pons;
RX   PubMed=9710270;
RX   DOI=10.1002/(sici)1097-4547(19980815)53:4<494::aid-jnr12>3.0.co;2-2;
RA   Jaszai J., Farkas L.M., Galter D., Reuss B., Strelau J., Unsicker K.,
RA   Krieglstein K.;
RT   "GDNF-related factor persephin is widely distributed throughout the nervous
RT   system.";
RL   J. Neurosci. Res. 53:494-501(1998).
RN   [3]
RP   TISSUE SPECIFICITY.
RX   PubMed=10719212; DOI=10.1016/s0169-328x(99)00328-9;
RA   Stoever T., Gong T.-W.L., Cho Y., Altschuler R.A., Lomax M.I.;
RT   "Expression of the GDNF family members and their receptors in the mature
RT   rat cochlea.";
RL   Brain Res. Mol. Brain Res. 76:25-35(2000).
CC   -!- FUNCTION: Exhibits neurotrophic activity on mesencephalic dopaminergic
CC       and motor neurons.
CC   -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Cochlea. Expressed at low levels in substantia
CC       nigra. {ECO:0000269|PubMed:10719212}.
CC   -!- SIMILARITY: Belongs to the TGF-beta family. GDNF subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AF040961; AAC40058.1; -; mRNA.
DR   EMBL; AJ005169; CAA06410.1; -; Genomic_DNA.
DR   RefSeq; NP_037146.1; NM_013014.1.
DR   AlphaFoldDB; O70301; -.
DR   SMR; O70301; -.
DR   STRING; 10116.ENSRNOP00000065156; -.
DR   PaxDb; O70301; -.
DR   Ensembl; ENSRNOT00000114711; ENSRNOP00000077509; ENSRNOG00000071190.
DR   GeneID; 25525; -.
DR   KEGG; rno:25525; -.
DR   CTD; 5623; -.
DR   RGD; 3432; Pspn.
DR   eggNOG; ENOG502S9IE; Eukaryota.
DR   GeneTree; ENSGT00950000182993; -.
DR   HOGENOM; CLU_102221_2_0_1; -.
DR   InParanoid; O70301; -.
DR   OMA; TFRYCAG; -.
DR   OrthoDB; 1373819at2759; -.
DR   PhylomeDB; O70301; -.
DR   Reactome; R-RNO-5673001; RAF/MAP kinase cascade.
DR   Reactome; R-RNO-8853659; RET signaling.
DR   PRO; PR:O70301; -.
DR   Proteomes; UP000002494; Chromosome 9.
DR   Bgee; ENSRNOG00000049171; Expressed in cerebellum and 19 other tissues.
DR   Genevisible; O70301; RN.
DR   GO; GO:0005615; C:extracellular space; ISO:RGD.
DR   GO; GO:0030116; F:glial cell-derived neurotrophic factor receptor binding; IEA:InterPro.
DR   GO; GO:0008083; F:growth factor activity; IBA:GO_Central.
DR   GO; GO:0030971; F:receptor tyrosine kinase binding; IEA:InterPro.
DR   GO; GO:0001658; P:branching involved in ureteric bud morphogenesis; ISO:RGD.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR043401; GDNF_fam.
DR   InterPro; IPR001839; TGF-b_C.
DR   PANTHER; PTHR12173; PTHR12173; 1.
DR   Pfam; PF00019; TGF_beta; 1.
DR   SUPFAM; SSF57501; SSF57501; 1.
DR   PROSITE; PS51362; TGF_BETA_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Growth factor; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..156
FT                   /note="Persephin"
FT                   /id="PRO_0000034016"
FT   DISULFID        66..124
FT                   /evidence="ECO:0000250"
FT   DISULFID        93..152
FT                   /evidence="ECO:0000250"
FT   DISULFID        97..154
FT                   /evidence="ECO:0000250"
FT   DISULFID        123
FT                   /note="Interchain"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   156 AA;  17063 MW;  9631941CC69B00B0 CRC64;
     MAAGRLRILF LLLLSLHLGL GWVLDLQEAP AADELSSGKM AETGRTWKPH QGNNNVRLPR
     ALPGLCRLWS LTLPVAELGL GYASEEKIIF RYCAGSCPQE VRTQHSLVLA RLRGQGRAHG
     RPCCQPTSYA DVTFLDDHHH WQQLPQLSAA ACGCGG