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PSR1_PHYSO
ID   PSR1_PHYSO              Reviewed;         106 AA.
AC   E0W5Q5;
DT   16-OCT-2019, integrated into UniProtKB/Swiss-Prot.
DT   02-NOV-2010, sequence version 1.
DT   25-MAY-2022, entry version 27.
DE   RecName: Full=RxLR effector protein PSR1 {ECO:0000303|PubMed:21653195};
DE   AltName: Full=Avirulence homolog protein 18 {ECO:0000303|PubMed:21653195};
DE   AltName: Full=Suppressor of RNA silencing protein 1 {ECO:0000303|PubMed:23377181};
DE   Flags: Precursor;
GN   Name=PSR1 {ECO:0000303|PubMed:23377181};
GN   Synonyms=Avh18 {ECO:0000303|PubMed:21653195};
OS   Phytophthora sojae (Soybean stem and root rot agent) (Phytophthora
OS   megasperma f. sp. glycines).
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC   Phytophthora.
OX   NCBI_TaxID=67593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND DOMAIN.
RC   STRAIN=P7074, and P7076;
RX   PubMed=21653195; DOI=10.1105/tpc.111.086082;
RA   Wang Q., Han C., Ferreira A.O., Yu X., Ye W., Tripathy S., Kale S.D.,
RA   Gu B., Sheng Y., Sui Y., Wang X., Zhang Z., Cheng B., Dong S., Shan W.,
RA   Zheng X., Dou D., Tyler B.M., Wang Y.;
RT   "Transcriptional programming and functional interactions within the
RT   Phytophthora sojae RXLR effector repertoire.";
RL   Plant Cell 23:2064-2086(2011).
RN   [2]
RP   FUNCTION, DOMAIN, SUBCELLULAR LOCATION, AND MUTAGENESIS OF 56-ARG--PHE-69.
RX   PubMed=23377181; DOI=10.1038/ng.2525;
RA   Qiao Y., Liu L., Xiong Q., Flores C., Wong J., Shi J., Wang X., Liu X.,
RA   Xiang Q., Jiang S., Zhang F., Wang Y., Judelson H.S., Chen X., Ma W.;
RT   "Oomycete pathogens encode RNA silencing suppressors.";
RL   Nat. Genet. 45:330-333(2013).
RN   [3]
RP   FUNCTION, AND INTERACTION WITH HOST PINP1.
RX   PubMed=25902521; DOI=10.1073/pnas.1421475112;
RA   Qiao Y., Shi J., Zhai Y., Hou Y., Ma W.;
RT   "Phytophthora effector targets a novel component of small RNA pathway in
RT   plants to promote infection.";
RL   Proc. Natl. Acad. Sci. U.S.A. 112:5850-5855(2015).
RN   [4]
RP   FUNCTION, DOMAIN, AND MUTAGENESIS OF TRP-72 AND TYR-100.
RX   PubMed=30963588; DOI=10.1111/nph.15836;
RA   Zhang P., Jia Y., Shi J., Chen C., Ye W., Wang Y., Ma W., Qiao Y.;
RT   "The WY domain in the Phytophthora effector PSR1 is required for infection
RT   and RNA silencing suppression activity.";
RL   New Phytol. 223:839-852(2019).
CC   -!- FUNCTION: Secreted effector that possesses RNA silencing suppression
CC       activity by inhibiting the biogenesis of small RNAs in the host plant
CC       to promote enhanced susceptibility of host to the pathogen during
CC       infection (PubMed:23377181, PubMed:25902521, PubMed:30963588).
CC       Interferes with secondary siRNA production by associating with host
CC       nuclear protein PINP1 that acts as a regulator of the accumulation of
CC       both microRNAs and endogenous small interfering RNAs (PubMed:25902521).
CC       {ECO:0000269|PubMed:23377181, ECO:0000269|PubMed:25902521,
CC       ECO:0000269|PubMed:30963588}.
CC   -!- SUBUNIT: Interacts with host PINP1. {ECO:0000269|PubMed:25902521}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:25902521}. Host
CC       nucleus {ECO:0000269|PubMed:25902521}. Note=The nuclear localization is
CC       required for this interaction. {ECO:0000269|PubMed:25902521}.
CC   -!- DOMAIN: The RxLR-dEER motif acts to carry the protein into the host
CC       cell cytoplasm through binding to cell surface phosphatidylinositol-3-
CC       phosphate. {ECO:0000305|PubMed:21653195}.
CC   -!- DOMAIN: The nuclear localization signal (NLS) is required for
CC       localization to the host nucleus and RNA silencing suppression
CC       activity. {ECO:0000269|PubMed:23377181}.
CC   -!- DOMAIN: The single WY domain is required for binding to host PINP1 and
CC       subsequent RNA-silencing suppression activity, pathogenicity and
CC       perturbation of plant development. {ECO:0000269|PubMed:30963588}.
CC   -!- SIMILARITY: Belongs to the RxLR effector family. {ECO:0000305}.
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DR   EMBL; JN253674; AEK80487.1; -; Genomic_DNA.
DR   EMBL; JN253675; AEK80488.1; -; Genomic_DNA.
DR   RefSeq; XP_009518240.1; XM_009519945.1.
DR   AlphaFoldDB; E0W5Q5; -.
DR   GeneID; 20639842; -.
DR   KEGG; psoj:PHYSODRAFT_284677; -.
DR   VEuPathDB; FungiDB:PHYSODRAFT_284677; -.
DR   HOGENOM; CLU_2228539_0_0_1; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR031825; RXLR.
DR   Pfam; PF16810; RXLR; 1.
PE   1: Evidence at protein level;
KW   Host nucleus; Secreted; Signal; Virulence.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..106
FT                   /note="RxLR effector protein PSR1"
FT                   /id="PRO_5007652867"
FT   REGION          50..106
FT                   /note="WY domain"
FT                   /evidence="ECO:0000305|PubMed:30963588"
FT   MOTIF           33..46
FT                   /note="RxLR-dEER"
FT                   /evidence="ECO:0000305|PubMed:21653195"
FT   MOTIF           56..69
FT                   /note="Bipartite nuclear localization signal (NLS)"
FT                   /evidence="ECO:0000269|PubMed:23377181"
FT   MUTAGEN         56..69
FT                   /note="RKMLGDETYRLKKF->AAAAAAAAAAAAAA: Loses the nuclear
FT                   localization as well as the RNA silencing 3suppression
FT                   activity."
FT                   /evidence="ECO:0000269|PubMed:23377181"
FT   MUTAGEN         72
FT                   /note="W->A: Abolishes the interaction with host target
FT                   PINP1 and lowers the size of lesions in leaves after
FT                   infection."
FT                   /evidence="ECO:0000269|PubMed:30963588"
FT   MUTAGEN         100
FT                   /note="Y->A: LAbolishes the interaction with host target
FT                   PINP1 and lowers the size of lesions in leaves after
FT                   infection."
FT                   /evidence="ECO:0000269|PubMed:30963588"
SQ   SEQUENCE   106 AA;  12304 MW;  DCDE91B059ABF2CF CRC64;
     MRLTYVLLVA VTTLLVSCDA TKPSTEATAV SKRLLRFVEA ADEEERRIDF SPEKLRKMLG
     DETYRLKKFG KWDSDGHTFD GLKHYLLLSD SSMVKLRNMY KAWLEQ
 
 
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