ID   ATNG_BOVIN              Reviewed;          58 AA.
AC   Q04645;
DT   01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1993, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Sodium/potassium-transporting ATPase subunit gamma;
DE            Short=Na(+)/K(+) ATPase subunit gamma;
DE   AltName: Full=FXYD domain-containing ion transport regulator 2;
DE   AltName: Full=Sodium pump gamma chain;
GN   Name=FXYD2; Synonyms=ATP1C, ATP1G1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Kidney;
RX   PubMed=8387529; DOI=10.1083/jcb.121.3.579;
RA   Mercer R.W., Biemesderfer D., Bliss D.P. Jr., Collins J.H., Forbush B. III;
RT   "Molecular cloning and immunological characterization of the gamma
RT   polypeptide, a small protein associated with the Na,K-ATPase.";
RL   J. Cell Biol. 121:579-586(1993).
CC   -!- FUNCTION: May be involved in forming the receptor site for cardiac
CC       glycoside binding or may modulate the transport function of the sodium
CC       ATPase.
CC   -!- SUBUNIT: Regulatory subunit of the sodium/potassium-transporting ATPase
CC       which is composed of a catalytic alpha subunit, an auxiliary non-
CC       catalytic beta subunit and an additional regulatory subunit.
CC       {ECO:0000250|UniProtKB:O13001}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type III
CC       membrane protein {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Highest levels expressed in the kidney and spleen.
CC       Restricted to the basolateral membrane in renal epithelial cells and
CC       varies in its level of expression along the nephron.
CC   -!- SIMILARITY: Belongs to the FXYD family. {ECO:0000305}.
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DR   EMBL; X70059; CAA49663.1; -; mRNA.
DR   PIR; D46435; D46435.
DR   PDB; 4XE5; X-ray; 3.90 A; G=1-58.
DR   PDBsum; 4XE5; -.
DR   AlphaFoldDB; Q04645; -.
DR   SMR; Q04645; -.
DR   STRING; 9913.ENSBTAP00000012957; -.
DR   PaxDb; Q04645; -.
DR   eggNOG; ENOG502SGMI; Eukaryota.
DR   InParanoid; Q04645; -.
DR   OrthoDB; 1325350at2759; -.
DR   BRENDA; 7.2.2.13; 908.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0099106; F:ion channel regulator activity; IEA:InterPro.
DR   GO; GO:0006813; P:potassium ion transport; IEA:UniProtKB-KW.
DR   GO; GO:0043269; P:regulation of ion transport; IEA:InterPro.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR000272; Ion-transport_regulator_FXYD.
DR   Pfam; PF02038; ATP1G1_PLM_MAT8; 1.
DR   PROSITE; PS01310; FXYD; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Ion transport; Membrane; Potassium; Potassium transport;
KW   Reference proteome; Sodium; Sodium transport; Sodium/potassium transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..58
FT                   /note="Sodium/potassium-transporting ATPase subunit gamma"
FT                   /id="PRO_0000148184"
FT   TRANSMEM        20..39
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   58 AA;  6545 MW;  54B590B816731183 CRC64;
     MVAVQGTEDP FYYDYETVRN GGLIFAALAF IVGLVIILSK RFRCGAKRQH RQIPEDGL