ATNG_RAT
ID ATNG_RAT Reviewed; 66 AA.
AC Q04679; Q9JKN3; Q9WUD3;
DT 01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2002, sequence version 2.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Sodium/potassium-transporting ATPase subunit gamma;
DE Short=Na(+)/K(+) ATPase subunit gamma;
DE AltName: Full=FXYD domain-containing ion transport regulator 2;
DE AltName: Full=Sodium pump gamma chain;
GN Name=Fxyd2; Synonyms=Atp1c, Atp1g1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Kidney;
RX PubMed=8387529; DOI=10.1083/jcb.121.3.579;
RA Mercer R.W., Biemesderfer D., Bliss D.P. Jr., Collins J.H., Forbush B. III;
RT "Molecular cloning and immunological characterization of the gamma
RT polypeptide, a small protein associated with the Na,K-ATPase.";
RL J. Cell Biol. 121:579-586(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC STRAIN=Sprague-Dawley;
RX PubMed=10212192; DOI=10.1074/jbc.274.18.12252;
RA Therien A.G., Karlish S.J., Blostein R.;
RT "Expression and functional role of the gamma subunit of the Na,K-ATPase in
RT mammalian cells.";
RL J. Biol. Chem. 274:12252-12256(1999).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RX PubMed=11832419; DOI=10.1152/ajprenal.00146.2001;
RA Arystarkhova E., Wetzel R.K., Sweadner K.J.;
RT "Distribution and oligomeric association of splice forms of Na(+)-K(+)-
RT ATPase regulatory gamma-subunit in rat kidney.";
RL Am. J. Physiol. 282:F393-F407(2002).
CC -!- FUNCTION: May be involved in forming the receptor site for cardiac
CC glycoside binding or may modulate the transport function of the sodium
CC ATPase.
CC -!- SUBUNIT: Regulatory subunit of the sodium/potassium-transporting ATPase
CC which is composed of a catalytic alpha subunit, an auxiliary non-
CC catalytic beta subunit and an additional regulatory subunit.
CC {ECO:0000250|UniProtKB:O13001}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type III
CC membrane protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1; Synonyms=A;
CC IsoId=Q04679-1; Sequence=Displayed;
CC Name=2; Synonyms=B;
CC IsoId=Q04679-2; Sequence=VSP_001583;
CC -!- TISSUE SPECIFICITY: Highest levels expressed in the kidney and spleen.
CC Restricted to the basolateral membrane in renal epithelial cells and
CC varies in its level of expression along the nephron.
CC -!- SIMILARITY: Belongs to the FXYD family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA49666.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; X70062; CAA49666.1; ALT_FRAME; mRNA.
DR EMBL; AF129400; AAD32613.1; -; mRNA.
DR EMBL; AF233060; AAF36985.1; -; mRNA.
DR PIR; B46435; B46435.
DR RefSeq; NP_059045.2; NM_017349.2. [Q04679-2]
DR RefSeq; NP_663769.1; NM_145717.1. [Q04679-1]
DR RefSeq; XP_006242973.1; XM_006242911.3. [Q04679-1]
DR RefSeq; XP_006242974.1; XM_006242912.3. [Q04679-2]
DR AlphaFoldDB; Q04679; -.
DR STRING; 10116.ENSRNOP00000022074; -.
DR PaxDb; Q04679; -.
DR PRIDE; Q04679; -.
DR GeneID; 29639; -.
DR KEGG; rno:29639; -.
DR UCSC; RGD:2173; rat. [Q04679-1]
DR CTD; 486; -.
DR RGD; 2173; Fxyd2.
DR VEuPathDB; HostDB:ENSRNOG00000016469; -.
DR eggNOG; ENOG502SGMI; Eukaryota.
DR HOGENOM; CLU_171208_4_0_1; -.
DR InParanoid; Q04679; -.
DR OMA; HRQVNED; -.
DR OrthoDB; 1597603at2759; -.
DR PhylomeDB; Q04679; -.
DR Reactome; R-RNO-5578775; Ion homeostasis.
DR Reactome; R-RNO-936837; Ion transport by P-type ATPases.
DR SABIO-RK; Q04679; -.
DR PRO; PR:Q04679; -.
DR Proteomes; UP000002494; Chromosome 8.
DR Bgee; ENSRNOG00000016469; Expressed in kidney and 19 other tissues.
DR Genevisible; Q04679; RN.
DR GO; GO:0016323; C:basolateral plasma membrane; IDA:RGD.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:RGD.
DR GO; GO:0016020; C:membrane; ISO:RGD.
DR GO; GO:0005886; C:plasma membrane; IDA:RGD.
DR GO; GO:0005890; C:sodium:potassium-exchanging ATPase complex; IDA:RGD.
DR GO; GO:0017080; F:sodium channel regulator activity; ISO:RGD.
DR GO; GO:0071475; P:cellular hyperosmotic salinity response; IEP:RGD.
DR GO; GO:0098662; P:inorganic cation transmembrane transport; IDA:RGD.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IMP:RGD.
DR GO; GO:1903407; P:negative regulation of P-type sodium:potassium-exchanging transporter activity; IMP:RGD.
DR GO; GO:0006813; P:potassium ion transport; IEA:UniProtKB-KW.
DR GO; GO:1903406; P:regulation of P-type sodium:potassium-exchanging transporter activity; IDA:RGD.
DR GO; GO:2000649; P:regulation of sodium ion transmembrane transporter activity; ISO:RGD.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR000272; Ion-transport_regulator_FXYD.
DR Pfam; PF02038; ATP1G1_PLM_MAT8; 1.
DR PROSITE; PS01310; FXYD; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Ion transport; Membrane; Potassium;
KW Potassium transport; Reference proteome; Sodium; Sodium transport;
KW Sodium/potassium transport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..66
FT /note="Sodium/potassium-transporting ATPase subunit gamma"
FT /id="PRO_0000148187"
FT TRANSMEM 29..46
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..8
FT /note="MTELSANH -> MDRWYL (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11832419"
FT /id="VSP_001583"
SQ SEQUENCE 66 AA; 7257 MW; 95D5CB3783410C06 CRC64;
MTELSANHGG SAKGTENPFE YDYETVRKGG LIFAGLAFVV GLLILLSKRF RCGGSKKHRQ
VNEDEL
