ID   ATNG_SHEEP              Reviewed;          53 AA.
AC   Q04680;
DT   01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 2.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Sodium/potassium-transporting ATPase subunit gamma;
DE            Short=Na(+)/K(+) ATPase subunit gamma;
DE   AltName: Full=FXYD domain-containing ion transport regulator 2;
DE   AltName: Full=Sodium pump gamma chain;
DE   Flags: Fragment;
GN   Name=FXYD2; Synonyms=ATP1C, ATP1G1;
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 6-53.
RC   TISSUE=Kidney;
RX   PubMed=8387529; DOI=10.1083/jcb.121.3.579;
RA   Mercer R.W., Biemesderfer D., Bliss D.P. Jr., Collins J.H., Forbush B. III;
RT   "Molecular cloning and immunological characterization of the gamma
RT   polypeptide, a small protein associated with the Na,K-ATPase.";
RL   J. Cell Biol. 121:579-586(1993).
RN   [2]
RP   PROTEIN SEQUENCE OF 1-33.
RC   TISSUE=Kidney;
RX   PubMed=2831947; DOI=10.1021/bi00400a026;
RA   Collins J.H., Leszyk J.;
RT   "The 'gamma subunit' of Na,K-ATPase: a small, amphiphilic protein with a
RT   unique amino acid sequence.";
RL   Biochemistry 26:8665-8668(1987).
CC   -!- FUNCTION: May be involved in forming the receptor site for cardiac
CC       glycoside binding or may modulate the transport function of the sodium
CC       ATPase.
CC   -!- SUBUNIT: Regulatory subunit of the sodium/potassium-transporting ATPase
CC       which is composed of a catalytic alpha subunit, an auxiliary non-
CC       catalytic beta subunit and an additional regulatory subunit.
CC       {ECO:0000250|UniProtKB:O13001}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type III
CC       membrane protein {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Highest levels expressed in the kidney and spleen.
CC       Restricted to the basolateral membrane in renal epithelial cells and
CC       varies in its level of expression along the nephron.
CC   -!- PTM: The N-terminus is blocked.
CC   -!- SIMILARITY: Belongs to the FXYD family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X70061; CAA49665.1; -; mRNA.
DR   PIR; A46435; A46435.
DR   AlphaFoldDB; Q04680; -.
DR   SMR; Q04680; -.
DR   STRING; 9940.ENSOARP00000007530; -.
DR   eggNOG; ENOG502SGMI; Eukaryota.
DR   Proteomes; UP000002356; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0099106; F:ion channel regulator activity; IEA:InterPro.
DR   GO; GO:0006813; P:potassium ion transport; IEA:UniProtKB-KW.
DR   GO; GO:0043269; P:regulation of ion transport; IEA:InterPro.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR000272; Ion-transport_regulator_FXYD.
DR   Pfam; PF02038; ATP1G1_PLM_MAT8; 1.
DR   PROSITE; PS01310; FXYD; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Ion transport; Membrane; Potassium;
KW   Potassium transport; Reference proteome; Sodium; Sodium transport;
KW   Sodium/potassium transport; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           <1..53
FT                   /note="Sodium/potassium-transporting ATPase subunit gamma"
FT                   /id="PRO_0000148188"
FT   TRANSMEM        16..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   NON_TER         1
SQ   SEQUENCE   53 AA;  6073 MW;  C0B52783D804AFB0 CRC64;
     ENEDPFYYDY ETVRNGGLIF AALAFIVGLV IILSKRFRCG AKKKHRQIPE DGL