ID   ATNG_XENLA              Reviewed;          61 AA.
AC   O13001;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Sodium/potassium-transporting ATPase subunit gamma;
DE            Short=Na(+)/K(+) ATPase subunit gamma;
DE   AltName: Full=FXYD domain-containing ion transport regulator 2;
DE   AltName: Full=Sodium pump gamma chain;
GN   Name=fxyd2;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND IDENTIFICATION IN
RP   SODIUM/POTASSIUM-TRANSPORTING ATPASE COMPLEX.
RC   TISSUE=Kidney;
RX   PubMed=9250668; DOI=10.1093/emboj/16.14.4250;
RA   Beguin P., Wang X., Firsov D., Puoti A., Claeys D., Horisberger J.-D.,
RA   Geering K.;
RT   "The gamma subunit is a specific component of the Na,K-ATPase and modulates
RT   its transport function.";
RL   EMBO J. 16:4250-4260(1997).
CC   -!- FUNCTION: May be involved in forming the receptor site for cardiac
CC       glycoside binding or may modulate the transport function of the sodium
CC       ATPase.
CC   -!- SUBUNIT: Regulatory subunit of the sodium/potassium-transporting ATPase
CC       which is composed of a catalytic alpha subunit, an auxiliary non-
CC       catalytic beta subunit and an additional regulatory subunit.
CC       {ECO:0000269|PubMed:9250668}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type III
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the FXYD family. {ECO:0000305}.
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DR   EMBL; Y11587; CAA72326.1; -; mRNA.
DR   RefSeq; NP_001081551.1; NM_001088082.2.
DR   AlphaFoldDB; O13001; -.
DR   SMR; O13001; -.
DR   GeneID; 397916; -.
DR   KEGG; xla:397916; -.
DR   CTD; 397916; -.
DR   Xenbase; XB-GENE-864939; fxyd2.S.
DR   OrthoDB; 1597603at2759; -.
DR   Proteomes; UP000186698; Chromosome 7S.
DR   Bgee; 397916; Expressed in kidney and 16 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0099106; F:ion channel regulator activity; IEA:InterPro.
DR   GO; GO:0006813; P:potassium ion transport; IEA:UniProtKB-KW.
DR   GO; GO:0043269; P:regulation of ion transport; IEA:InterPro.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR000272; Ion-transport_regulator_FXYD.
DR   Pfam; PF02038; ATP1G1_PLM_MAT8; 1.
DR   PROSITE; PS01310; FXYD; 1.
PE   1: Evidence at protein level;
KW   Ion transport; Membrane; Potassium; Potassium transport;
KW   Reference proteome; Sodium; Sodium transport; Sodium/potassium transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..61
FT                   /note="Sodium/potassium-transporting ATPase subunit gamma"
FT                   /id="PRO_0000148189"
FT   TRANSMEM        24..44
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   61 AA;  6999 MW;  E34DD85B20A6A19E CRC64;
     MADAQDDMSQ MQDKFTYDYE TIRKGGLIFA AIAFVVGMLI IFSGRFRCGR KKQLRALNDD
     M