PSS1_ORYSJ
ID PSS1_ORYSJ Reviewed; 425 AA.
AC Q0JR55; E0Y3X2;
DT 09-JUL-2014, integrated into UniProtKB/Swiss-Prot.
DT 09-JUL-2014, sequence version 2.
DT 03-AUG-2022, entry version 79.
DE RecName: Full=CDP-diacylglycerol--serine O-phosphatidyltransferase 1;
DE EC=2.7.8.8;
DE AltName: Full=Phosphatidylserine synthase 1;
GN Name=PSS1; OrderedLocusNames=Os01g0118300, LOC_Os01g02890;
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Yin H.;
RT "Control of rice development.";
RL Submitted (JAN-2010) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12447438; DOI=10.1038/nature01184;
RA Sasaki T., Matsumoto T., Yamamoto K., Sakata K., Baba T., Katayose Y.,
RA Wu J., Niimura Y., Cheng Z., Nagamura Y., Antonio B.A., Kanamori H.,
RA Hosokawa S., Masukawa M., Arikawa K., Chiden Y., Hayashi M., Okamoto M.,
RA Ando T., Aoki H., Arita K., Hamada M., Harada C., Hijishita S., Honda M.,
RA Ichikawa Y., Idonuma A., Iijima M., Ikeda M., Ikeno M., Ito S., Ito T.,
RA Ito Y., Ito Y., Iwabuchi A., Kamiya K., Karasawa W., Katagiri S.,
RA Kikuta A., Kobayashi N., Kono I., Machita K., Maehara T., Mizuno H.,
RA Mizubayashi T., Mukai Y., Nagasaki H., Nakashima M., Nakama Y.,
RA Nakamichi Y., Nakamura M., Namiki N., Negishi M., Ohta I., Ono N., Saji S.,
RA Sakai K., Shibata M., Shimokawa T., Shomura A., Song J., Takazaki Y.,
RA Terasawa K., Tsuji K., Waki K., Yamagata H., Yamane H., Yoshiki S.,
RA Yoshihara R., Yukawa K., Zhong H., Iwama H., Endo T., Ito H., Hahn J.H.,
RA Kim H.-I., Eun M.-Y., Yano M., Jiang J., Gojobori T.;
RT "The genome sequence and structure of rice chromosome 1.";
RL Nature 420:312-316(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [5]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12869764; DOI=10.1126/science.1081288;
RG The rice full-length cDNA consortium;
RT "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT japonica rice.";
RL Science 301:376-379(2003).
CC -!- FUNCTION: Catalyzes a base-exchange reaction in which the polar head
CC group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is
CC replaced by L-serine. {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a CDP-1,2-diacyl-sn-glycerol + L-serine = a 1,2-diacyl-sn-
CC glycero-3-phospho-L-serine + CMP + H(+); Xref=Rhea:RHEA:16913,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:33384, ChEBI:CHEBI:57262,
CC ChEBI:CHEBI:58332, ChEBI:CHEBI:60377; EC=2.7.8.8;
CC -!- PATHWAY: Phospholipid metabolism; phosphatidylethanolamine
CC biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step
CC 1/2.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the CDP-alcohol phosphatidyltransferase class-I
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AK065788; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=BAF03773.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; GU564663; ADK94872.1; -; mRNA.
DR EMBL; AP002541; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AP008207; BAF03773.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AP014957; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK065788; -; NOT_ANNOTATED_CDS; mRNA.
DR RefSeq; XP_015626869.1; XM_015771383.1.
DR AlphaFoldDB; Q0JR55; -.
DR STRING; 4530.OS01T0118300-01; -.
DR PaxDb; Q0JR55; -.
DR PRIDE; Q0JR55; -.
DR EnsemblPlants; Os01t0118300-02; Os01t0118300-02; Os01g0118300.
DR GeneID; 4326076; -.
DR Gramene; Os01t0118300-02; Os01t0118300-02; Os01g0118300.
DR KEGG; osa:4326076; -.
DR eggNOG; KOG2735; Eukaryota.
DR InParanoid; Q0JR55; -.
DR OrthoDB; 818196at2759; -.
DR BRENDA; 2.7.8.8; 8948.
DR PlantReactome; R-OSA-1119402; Phospholipid biosynthesis I.
DR UniPathway; UPA00558; UER00615.
DR Proteomes; UP000000763; Chromosome 1.
DR Proteomes; UP000059680; Chromosome 1.
DR ExpressionAtlas; Q0JR55; baseline and differential.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0003882; F:CDP-diacylglycerol-serine O-phosphatidyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0106245; F:L-serine-phosphatidylethanolamine phosphatidyltransferase activity; IEA:InterPro.
DR GO; GO:0006646; P:phosphatidylethanolamine biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006659; P:phosphatidylserine biosynthetic process; IEA:InterPro.
DR InterPro; IPR004277; PSS.
DR Pfam; PF03034; PSS; 1.
PE 2: Evidence at transcript level;
KW Endoplasmic reticulum; Lipid biosynthesis; Lipid metabolism; Membrane;
KW Phospholipid biosynthesis; Phospholipid metabolism; Reference proteome;
KW Transferase; Transmembrane; Transmembrane helix.
FT CHAIN 1..425
FT /note="CDP-diacylglycerol--serine O-phosphatidyltransferase
FT 1"
FT /id="PRO_0000429527"
FT TRANSMEM 42..62
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 79..99
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 105..125
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..217
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 224..244
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 296..316
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 321..341
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 366..386
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 393..413
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 48
FT /note="M -> T (in Ref. 1; ADK94872)"
FT /evidence="ECO:0000305"
FT CONFLICT 142
FT /note="L -> F (in Ref. 1; ADK94872)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 425 AA; 50100 MW; 1A6BFBE691053FBE CRC64;
MEVNGHHKPR REYNGRECNG VQSVNNFGDI DPWTAWAYKP RTVSLLLMGT CFLIWASGAL
DPERSFSVDR VSSVKRGVFA MIAVFLAYSF LQAPSTVLIR PHPAIWRLVH GMAVVYLVAL
TFLLFQTRDD ARQFMKYLHP DLGVELPERS YGTDCRIYVP DHPKSRFNNV YEILFDEFVI
AHILGWWGKA IMIRNQPLLW VLSIGFELME LTFRHMLPNF NECWWDSIVL DILICNWFGI
WAGMKTVRYF DGRTYEWVGL SRQPNIISKV KRTLGQFTPA QWDKDEWYPL LGPWRFIQVL
SLCIVFMIVE LNTFFLKFCL WIPPRNPLIV YRLVLWWLIA IPTIREYNTY LQDRKPVKKV
GSFCWLSLAI CILELLLCIK FGHGLFPKSM PSWLFIAWTT VASLLMMFLL VWTWKIYRTM
IRKRL
