PSS_HAEIN
ID PSS_HAEIN Reviewed; 455 AA.
AC P44704;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=CDP-diacylglycerol--serine O-phosphatidyltransferase;
DE EC=2.7.8.8;
DE AltName: Full=Phosphatidylserine synthase;
GN Name=pssA; OrderedLocusNames=HI_0425;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a CDP-1,2-diacyl-sn-glycerol + L-serine = a 1,2-diacyl-sn-
CC glycero-3-phospho-L-serine + CMP + H(+); Xref=Rhea:RHEA:16913,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:33384, ChEBI:CHEBI:57262,
CC ChEBI:CHEBI:58332, ChEBI:CHEBI:60377; EC=2.7.8.8;
CC -!- SUBUNIT: Multimeric.
CC -!- SUBCELLULAR LOCATION: Cytoplasm. Cell inner membrane {ECO:0000250};
CC Peripheral membrane protein {ECO:0000250}; Cytoplasmic side
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CDP-alcohol phosphatidyltransferase class-II
CC family. {ECO:0000305}.
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DR EMBL; L42023; AAC22084.1; -; Genomic_DNA.
DR PIR; I64066; I64066.
DR RefSeq; NP_438586.1; NC_000907.1.
DR RefSeq; WP_005693739.1; NC_000907.1.
DR PDB; 3HSI; X-ray; 2.20 A; A/B/C=1-455.
DR PDBsum; 3HSI; -.
DR AlphaFoldDB; P44704; -.
DR SMR; P44704; -.
DR STRING; 71421.HI_0425; -.
DR DNASU; 950510; -.
DR EnsemblBacteria; AAC22084; AAC22084; HI_0425.
DR KEGG; hin:HI_0425; -.
DR PATRIC; fig|71421.8.peg.445; -.
DR eggNOG; COG1502; Bacteria.
DR HOGENOM; CLU_051350_1_0_6; -.
DR OMA; YLSTLYI; -.
DR PhylomeDB; P44704; -.
DR BioCyc; HINF71421:G1GJ1-440-MON; -.
DR EvolutionaryTrace; P44704; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008444; F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity; IEA:InterPro.
DR GO; GO:0003882; F:CDP-diacylglycerol-serine O-phosphatidyltransferase activity; IBA:GO_Central.
DR GO; GO:0032049; P:cardiolipin biosynthetic process; IEA:InterPro.
DR InterPro; IPR016270; PGS1.
DR InterPro; IPR025202; PLD-like_dom.
DR InterPro; IPR001736; PLipase_D/transphosphatidylase.
DR PANTHER; PTHR12586; PTHR12586; 1.
DR Pfam; PF13091; PLDc_2; 1.
DR SMART; SM00155; PLDc; 2.
DR PROSITE; PS50035; PLD; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell inner membrane; Cell membrane; Cytoplasm;
KW Lipid biosynthesis; Lipid metabolism; Membrane; Phospholipid biosynthesis;
KW Phospholipid metabolism; Reference proteome; Repeat; Transferase.
FT CHAIN 1..455
FT /note="CDP-diacylglycerol--serine O-
FT phosphatidyltransferase"
FT /id="PRO_0000056825"
FT DOMAIN 134..160
FT /note="PLD phosphodiesterase 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00153"
FT DOMAIN 356..383
FT /note="PLD phosphodiesterase 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00153"
FT HELIX 5..14
FT /evidence="ECO:0007829|PDB:3HSI"
FT STRAND 18..20
FT /evidence="ECO:0007829|PDB:3HSI"
FT HELIX 23..25
FT /evidence="ECO:0007829|PDB:3HSI"
FT STRAND 26..28
FT /evidence="ECO:0007829|PDB:3HSI"
FT HELIX 32..44
FT /evidence="ECO:0007829|PDB:3HSI"
FT STRAND 47..55
FT /evidence="ECO:0007829|PDB:3HSI"
FT HELIX 61..76
FT /evidence="ECO:0007829|PDB:3HSI"
FT STRAND 81..87
FT /evidence="ECO:0007829|PDB:3HSI"
FT HELIX 90..92
FT /evidence="ECO:0007829|PDB:3HSI"
FT HELIX 104..115
FT /evidence="ECO:0007829|PDB:3HSI"
FT STRAND 124..127
FT /evidence="ECO:0007829|PDB:3HSI"
FT STRAND 129..132
FT /evidence="ECO:0007829|PDB:3HSI"
FT HELIX 133..135
FT /evidence="ECO:0007829|PDB:3HSI"
FT STRAND 142..145
FT /evidence="ECO:0007829|PDB:3HSI"
FT STRAND 148..153
FT /evidence="ECO:0007829|PDB:3HSI"
FT TURN 158..162
FT /evidence="ECO:0007829|PDB:3HSI"
FT STRAND 172..176
FT /evidence="ECO:0007829|PDB:3HSI"
FT HELIX 178..190
FT /evidence="ECO:0007829|PDB:3HSI"
FT TURN 195..197
FT /evidence="ECO:0007829|PDB:3HSI"
FT STRAND 199..204
FT /evidence="ECO:0007829|PDB:3HSI"
FT HELIX 209..211
FT /evidence="ECO:0007829|PDB:3HSI"
FT HELIX 213..226
FT /evidence="ECO:0007829|PDB:3HSI"
FT STRAND 235..237
FT /evidence="ECO:0007829|PDB:3HSI"
FT STRAND 242..253
FT /evidence="ECO:0007829|PDB:3HSI"
FT HELIX 255..265
FT /evidence="ECO:0007829|PDB:3HSI"
FT STRAND 268..274
FT /evidence="ECO:0007829|PDB:3HSI"
FT STRAND 276..278
FT /evidence="ECO:0007829|PDB:3HSI"
FT HELIX 282..292
FT /evidence="ECO:0007829|PDB:3HSI"
FT TURN 293..295
FT /evidence="ECO:0007829|PDB:3HSI"
FT STRAND 297..303
FT /evidence="ECO:0007829|PDB:3HSI"
FT HELIX 305..307
FT /evidence="ECO:0007829|PDB:3HSI"
FT HELIX 320..323
FT /evidence="ECO:0007829|PDB:3HSI"
FT HELIX 324..338
FT /evidence="ECO:0007829|PDB:3HSI"
FT HELIX 340..345
FT /evidence="ECO:0007829|PDB:3HSI"
FT STRAND 346..353
FT /evidence="ECO:0007829|PDB:3HSI"
FT STRAND 358..360
FT /evidence="ECO:0007829|PDB:3HSI"
FT STRAND 364..367
FT /evidence="ECO:0007829|PDB:3HSI"
FT TURN 368..370
FT /evidence="ECO:0007829|PDB:3HSI"
FT STRAND 371..375
FT /evidence="ECO:0007829|PDB:3HSI"
FT HELIX 381..385
FT /evidence="ECO:0007829|PDB:3HSI"
FT STRAND 388..395
FT /evidence="ECO:0007829|PDB:3HSI"
FT HELIX 402..413
FT /evidence="ECO:0007829|PDB:3HSI"
FT STRAND 416..418
FT /evidence="ECO:0007829|PDB:3HSI"
FT HELIX 422..424
FT /evidence="ECO:0007829|PDB:3HSI"
FT HELIX 428..430
FT /evidence="ECO:0007829|PDB:3HSI"
FT HELIX 433..444
FT /evidence="ECO:0007829|PDB:3HSI"
FT HELIX 447..454
FT /evidence="ECO:0007829|PDB:3HSI"
SQ SEQUENCE 455 AA; 53080 MW; 255CA66C1C45B9EB CRC64;
MLINKTKRAE QNLNNLPFLA LQAEQIEFLG SSAEFKTQII ELIRNAKKRI YVTALYWQKD
EAGQEILDEI YRVKQENPHL DVKVLIDWHR AQRNLLGAEK SATNADWYCE QRQTYQLPDD
PNMFFGVPIN TREVFGVLHV KGFVFDDTVL YSGASINNVY LHQFEKYRYD RYQKITHAEL
ADSMVNFIND YLLDFSAVYP LDVTNRPRTK EIRGNIRAYR KDLAQNGEYS LKSAVKLPNV
LSVSPLFGLG ASGNELNQVI EDLFLQVQKK LVICTPYFNF PRTLQHKIAT LLENGKRVEI
IVGDKVANDF YIPPEQPFKM AGALPYLYES NLRRFCEKFE TQIESGQLVV RLWRDGDNTY
HLKGVWVDDR YILLTGNNLN PRAWRLDAEN GLLIYDPQQQ LLAQVEKEQN QIRQHTKVLK
HYTELEELNQ YPEPVQKLLK KFARIKADKL VKMIL
