位置:首页 > 蛋白库 > PSS_HELPJ
PSS_HELPJ
ID   PSS_HELPJ               Reviewed;         237 AA.
AC   Q9ZM68;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 117.
DE   RecName: Full=CDP-diacylglycerol--serine O-phosphatidyltransferase;
DE            EC=2.7.8.8;
DE   AltName: Full=Phosphatidylserine synthase;
GN   Name=pssA; Synonyms=ptr; OrderedLocusNames=jhp_0354;
OS   Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=85963;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=J99 / ATCC 700824;
RX   PubMed=9923682; DOI=10.1038/16495;
RA   Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C.,
RA   Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J.,
RA   Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D.,
RA   Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trust T.J.;
RT   "Genomic sequence comparison of two unrelated isolates of the human gastric
RT   pathogen Helicobacter pylori.";
RL   Nature 397:176-180(1999).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a CDP-1,2-diacyl-sn-glycerol + L-serine = a 1,2-diacyl-sn-
CC         glycero-3-phospho-L-serine + CMP + H(+); Xref=Rhea:RHEA:16913,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:33384, ChEBI:CHEBI:57262,
CC         ChEBI:CHEBI:58332, ChEBI:CHEBI:60377; EC=2.7.8.8;
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the CDP-alcohol phosphatidyltransferase class-I
CC       family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE001439; AAD05934.1; -; Genomic_DNA.
DR   PIR; B71941; B71941.
DR   RefSeq; WP_001122212.1; NZ_CP011330.1.
DR   AlphaFoldDB; Q9ZM68; -.
DR   SMR; Q9ZM68; -.
DR   STRING; 85963.jhp_0354; -.
DR   EnsemblBacteria; AAD05934; AAD05934; jhp_0354.
DR   KEGG; hpj:jhp_0354; -.
DR   PATRIC; fig|85963.30.peg.657; -.
DR   eggNOG; COG1183; Bacteria.
DR   OMA; IFFDFFD; -.
DR   Proteomes; UP000000804; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0003882; F:CDP-diacylglycerol-serine O-phosphatidyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008654; P:phospholipid biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.120.1760; -; 1.
DR   InterPro; IPR004533; CDP-diaglyc--ser_O-PTrfase.
DR   InterPro; IPR000462; CDP-OH_P_trans.
DR   InterPro; IPR043130; CDP-OH_PTrfase_TM_dom.
DR   Pfam; PF01066; CDP-OH_P_transf; 1.
DR   TIGRFAMs; TIGR00473; pssA; 1.
DR   PROSITE; PS00379; CDP_ALCOHOL_P_TRANSF; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Lipid biosynthesis; Lipid metabolism; Membrane;
KW   Phospholipid biosynthesis; Phospholipid metabolism; Transferase;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..237
FT                   /note="CDP-diacylglycerol--serine O-
FT                   phosphatidyltransferase"
FT                   /id="PRO_0000056795"
FT   TRANSMEM        3..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        25..45
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        73..93
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        95..115
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        124..144
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        150..170
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        184..204
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        207..227
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   237 AA;  26604 MW;  F285CAA7B5A8347D CRC64;
     MPINPLYLFP NLFTASSIFL GMMSIFYASS YQFVMACWLV VASLILDGLD GRVARLTNTT
     SKFGIEFDSL ADVVAFGVAP SLITYFYVGY NFGRIGMAVS ALFVIFGAIR LARFNISTNT
     SDPYSFIGIP IPAAAVLVVL CVLLDNKYHF LEGNTEKLFL GFIVLLGVLM VSNIRYPNFK
     KVKWNLKLFI LVLIFLSLVF VRPLEALSVF MGLYLIYGII RWIFLMVKII FNKNKSA
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024