PSS_HELPY
ID PSS_HELPY Reviewed; 237 AA.
AC Q48269; O07681;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 2.
DT 25-MAY-2022, entry version 121.
DE RecName: Full=CDP-diacylglycerol--serine O-phosphatidyltransferase;
DE EC=2.7.8.8;
DE AltName: Full=Phosphatidylserine synthase;
GN Name=pssA; Synonyms=ptr; OrderedLocusNames=HP_1071;
OS Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori).
OC Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=85962;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=A68;
RX PubMed=8550601; DOI=10.1074/jbc.271.1.446;
RA Melchers K., Weitzenegger T., Buhmann A., Steinhilber W., Sachs G.,
RA Schaefer K.P.;
RT "Cloning and membrane topology of a P type ATPase from Helicobacter
RT pylori.";
RL J. Biol. Chem. 271:446-457(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=DSM 4867 / CCUG 17874 / NCTC 11638;
RX PubMed=9244252; DOI=10.1128/jb.179.15.4676-4683.1997;
RA Beier D., Spohn G., Rappuoli R., Scarlato V.;
RT "Identification and characterization of an operon of Helicobacter pylori
RT that is involved in motility and stress adaptation.";
RL J. Bacteriol. 179:4676-4683(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 43629 / JCM 7656 / NCTC 11639 / UA802;
RX PubMed=9260935; DOI=10.1128/jb.179.16.4970-4976.1997;
RA Ge Z., Taylor D.E.;
RT "The Helicobacter pylori gene encoding phosphatidylserine synthase:
RT sequence, expression, and insertional mutagenesis.";
RL J. Bacteriol. 179:4970-4976(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700392 / 26695;
RX PubMed=9252185; DOI=10.1038/41483;
RA Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A.,
RA Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N.,
RA Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., Glodek A.,
RA McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E.,
RA Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D.,
RA Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S.,
RA Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.;
RT "The complete genome sequence of the gastric pathogen Helicobacter
RT pylori.";
RL Nature 388:539-547(1997).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a CDP-1,2-diacyl-sn-glycerol + L-serine = a 1,2-diacyl-sn-
CC glycero-3-phospho-L-serine + CMP + H(+); Xref=Rhea:RHEA:16913,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:33384, ChEBI:CHEBI:57262,
CC ChEBI:CHEBI:58332, ChEBI:CHEBI:60377; EC=2.7.8.8;
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the CDP-alcohol phosphatidyltransferase class-I
CC family. {ECO:0000305}.
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DR EMBL; U59625; AAB05473.1; -; Genomic_DNA.
DR EMBL; U97567; AAB66379.1; -; Genomic_DNA.
DR EMBL; AF005718; AAC45587.1; -; Genomic_DNA.
DR EMBL; AE000511; AAD08116.1; -; Genomic_DNA.
DR PIR; G64653; G64653.
DR RefSeq; NP_207862.1; NC_000915.1.
DR RefSeq; WP_001122183.1; NC_018939.1.
DR AlphaFoldDB; Q48269; -.
DR SMR; Q48269; -.
DR STRING; 85962.C694_05535; -.
DR PaxDb; Q48269; -.
DR DNASU; 899607; -.
DR EnsemblBacteria; AAD08116; AAD08116; HP_1071.
DR KEGG; hpy:HP_1071; -.
DR PATRIC; fig|85962.47.peg.1150; -.
DR eggNOG; COG1183; Bacteria.
DR OMA; IFFDFFD; -.
DR PhylomeDB; Q48269; -.
DR Proteomes; UP000000429; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0003882; F:CDP-diacylglycerol-serine O-phosphatidyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0008654; P:phospholipid biosynthetic process; IEA:UniProtKB-KW.
DR Gene3D; 1.20.120.1760; -; 1.
DR InterPro; IPR004533; CDP-diaglyc--ser_O-PTrfase.
DR InterPro; IPR000462; CDP-OH_P_trans.
DR InterPro; IPR043130; CDP-OH_PTrfase_TM_dom.
DR Pfam; PF01066; CDP-OH_P_transf; 1.
DR TIGRFAMs; TIGR00473; pssA; 1.
DR PROSITE; PS00379; CDP_ALCOHOL_P_TRANSF; 1.
PE 3: Inferred from homology;
KW Cell membrane; Lipid biosynthesis; Lipid metabolism; Membrane;
KW Phospholipid biosynthesis; Phospholipid metabolism; Reference proteome;
KW Transferase; Transmembrane; Transmembrane helix.
FT CHAIN 1..237
FT /note="CDP-diacylglycerol--serine O-
FT phosphatidyltransferase"
FT /id="PRO_0000056794"
FT TRANSMEM 3..23
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 25..45
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 73..93
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 95..115
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 124..144
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 150..170
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 184..204
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 207..227
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VARIANT 84
FT /note="A -> T (in strain: A68 and UA802)"
FT VARIANT 138
FT /note="V -> M (in strain: NCTC 11638)"
FT VARIANT 202
FT /note="R -> H (in strain: NCTC 11638)"
FT VARIANT 237
FT /note="A -> T (in strain: NCTC 11638)"
SQ SEQUENCE 237 AA; 26618 MW; 3754B5858632CF12 CRC64;
MPINPLYLFP NLFTASSIFL GMMSIFYASS YQFVMACWLV VASLILDGLD GRVARLTNTT
SKFGIEFDSL ADVIAFGVAP SLIAYFYVGY NFGRIGMAVS ALFVIFGAIR LARFNISTNT
SDPYSFIGIP IPAAAVLVVL CVLLDNKYHF LEGNTEKLFL SFIVLLGVLM VSNIRYPNFK
KVKWNLKLFI LVLIFLSLVF VRPLEALSVF MGLYLIYGII RWLFLMVKII FNKNKSA
