ID   PSS_METJA               Reviewed;         201 AA.
AC   Q58609;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=CDP-diacylglycerol--serine O-phosphatidyltransferase;
DE            EC=2.7.8.8;
DE   AltName: Full=Phosphatidylserine synthase;
GN   Name=pssA; OrderedLocusNames=MJ1212;
OS   Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS   10045 / NBRC 100440) (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=243232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA   Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA   Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA   Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA   Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA   Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA   Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA   Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a CDP-1,2-diacyl-sn-glycerol + L-serine = a 1,2-diacyl-sn-
CC         glycero-3-phospho-L-serine + CMP + H(+); Xref=Rhea:RHEA:16913,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:33384, ChEBI:CHEBI:57262,
CC         ChEBI:CHEBI:58332, ChEBI:CHEBI:60377; EC=2.7.8.8;
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the CDP-alcohol phosphatidyltransferase class-I
CC       family. {ECO:0000305}.
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DR   EMBL; L77117; AAB99214.1; -; Genomic_DNA.
DR   PIR; C64451; C64451.
DR   RefSeq; WP_010870724.1; NC_000909.1.
DR   PDB; 7B1K; X-ray; 2.20 A; A/B=1-201.
DR   PDB; 7B1L; X-ray; 1.85 A; A/B=1-201.
DR   PDB; 7B1N; X-ray; 2.80 A; A/B=1-201.
DR   PDB; 7POW; X-ray; 2.51 A; A/B=1-201.
DR   PDBsum; 7B1K; -.
DR   PDBsum; 7B1L; -.
DR   PDBsum; 7B1N; -.
DR   PDBsum; 7POW; -.
DR   AlphaFoldDB; Q58609; -.
DR   SMR; Q58609; -.
DR   STRING; 243232.MJ_1212; -.
DR   DNASU; 1452108; -.
DR   EnsemblBacteria; AAB99214; AAB99214; MJ_1212.
DR   GeneID; 1452108; -.
DR   KEGG; mja:MJ_1212; -.
DR   eggNOG; arCOG00671; Archaea.
DR   HOGENOM; CLU_049944_3_1_2; -.
DR   InParanoid; Q58609; -.
DR   OMA; YSICGML; -.
DR   OrthoDB; 68873at2157; -.
DR   PhylomeDB; Q58609; -.
DR   Proteomes; UP000000805; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0003882; F:CDP-diacylglycerol-serine O-phosphatidyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008654; P:phospholipid biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.120.1760; -; 1.
DR   InterPro; IPR004533; CDP-diaglyc--ser_O-PTrfase.
DR   InterPro; IPR000462; CDP-OH_P_trans.
DR   InterPro; IPR043130; CDP-OH_PTrfase_TM_dom.
DR   Pfam; PF01066; CDP-OH_P_transf; 1.
DR   TIGRFAMs; TIGR00473; pssA; 1.
DR   PROSITE; PS00379; CDP_ALCOHOL_P_TRANSF; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cell membrane; Lipid biosynthesis; Lipid metabolism;
KW   Membrane; Phospholipid biosynthesis; Phospholipid metabolism;
KW   Reference proteome; Transferase; Transmembrane; Transmembrane helix.
FT   CHAIN           1..201
FT                   /note="CDP-diacylglycerol--serine O-
FT                   phosphatidyltransferase"
FT                   /id="PRO_0000056799"
FT   TRANSMEM        19..39
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        57..77
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        88..108
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        112..132
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        133..153
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        162..182
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   HELIX           3..6
FT                   /evidence="ECO:0007829|PDB:7B1L"
FT   HELIX           10..27
FT                   /evidence="ECO:0007829|PDB:7B1L"
FT   HELIX           31..51
FT                   /evidence="ECO:0007829|PDB:7B1L"
FT   HELIX           56..70
FT                   /evidence="ECO:0007829|PDB:7B1L"
FT   HELIX           72..81
FT                   /evidence="ECO:0007829|PDB:7B1L"
FT   HELIX           85..107
FT                   /evidence="ECO:0007829|PDB:7B1L"
FT   STRAND          111..116
FT                   /evidence="ECO:0007829|PDB:7B1L"
FT   HELIX           118..131
FT                   /evidence="ECO:0007829|PDB:7B1L"
FT   HELIX           135..149
FT                   /evidence="ECO:0007829|PDB:7B1L"
FT   HELIX           161..175
FT                   /evidence="ECO:0007829|PDB:7B1L"
FT   HELIX           180..199
FT                   /evidence="ECO:0007829|PDB:7B1L"
SQ   SEQUENCE   201 AA;  22014 MW;  D45D3201941615CA CRC64;
     MFSIRKIITI SDYVTMLNII TGLLAILLNS FSLIYLSIIF DSLDGYVARK TGTVSDFGAE
     LDSISDVVSF GVAPAYLLYN NFESNLALIS AIIFCLCGAL RLARFGILNV KGFIGLPIPA
     GALLLVGFCQ LINSYLINSI LAILIGLLMI SDIKYPKYPN KIFIYIFAVS LCLAIVGIPH
     FALMLCLIYA IYGIIKYIRG D