ID   PSS_MYCTO               Reviewed;         286 AA.
AC   P9WPG0; L0T6N4; P96282;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 26.
DE   RecName: Full=CDP-diacylglycerol--serine O-phosphatidyltransferase;
DE            EC=2.7.8.8;
DE   AltName: Full=Phosphatidylserine synthase;
GN   Name=pssA; OrderedLocusNames=MT0452;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a CDP-1,2-diacyl-sn-glycerol + L-serine = a 1,2-diacyl-sn-
CC         glycero-3-phospho-L-serine + CMP + H(+); Xref=Rhea:RHEA:16913,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:33384, ChEBI:CHEBI:57262,
CC         ChEBI:CHEBI:58332, ChEBI:CHEBI:60377; EC=2.7.8.8;
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CDP-alcohol phosphatidyltransferase class-I
CC       family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAK44675.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE000516; AAK44675.1; ALT_INIT; Genomic_DNA.
DR   PIR; B70632; B70632.
DR   RefSeq; WP_003402213.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WPG0; -.
DR   SMR; P9WPG0; -.
DR   EnsemblBacteria; AAK44675; AAK44675; MT0452.
DR   GeneID; 45424397; -.
DR   KEGG; mtc:MT0452; -.
DR   PATRIC; fig|83331.31.peg.479; -.
DR   HOGENOM; CLU_049944_1_1_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0003882; F:CDP-diacylglycerol-serine O-phosphatidyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008654; P:phospholipid biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.120.1760; -; 1.
DR   InterPro; IPR004533; CDP-diaglyc--ser_O-PTrfase.
DR   InterPro; IPR000462; CDP-OH_P_trans.
DR   InterPro; IPR043130; CDP-OH_PTrfase_TM_dom.
DR   Pfam; PF01066; CDP-OH_P_transf; 1.
DR   TIGRFAMs; TIGR00473; pssA; 1.
DR   PROSITE; PS00379; CDP_ALCOHOL_P_TRANSF; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Lipid biosynthesis; Lipid metabolism; Membrane;
KW   Phospholipid biosynthesis; Phospholipid metabolism; Transferase;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..286
FT                   /note="CDP-diacylglycerol--serine O-
FT                   phosphatidyltransferase"
FT                   /id="PRO_0000426958"
FT   TRANSMEM        15..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        74..94
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        95..115
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        135..155
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        167..187
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        207..227
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   286 AA;  31260 MW;  E7D56D9ADA740F5C CRC64;
     MIGKPRGRRG VNLQILPSAM TVLSICAGLT AIKFALEHQP KAAMALIAAA AILDGLDGRV
     ARILDAQSRM GAEIDSLADA VNFGVTPALV LYVSMLSKWP VGWVVVLLYA VCVVLRLARY
     NALQDDGTQP AYAHEFFVGM PAPAGAVSMI GLLALKMQFG EGWWTSVWFL SFWVTGTSIL
     LVSGIPMKKM HAVSVPPNYA AALLAVLAIC AAAAVLAPYL LIWVIIIAYM CHIPFAVRSQ
     RWLAQHPEVW DDKPKQRRAV RRASRRAHPY RPSMARLGLR KPGRRL