PSTA1_MYCTU
ID PSTA1_MYCTU Reviewed; 308 AA.
AC P9WG11; L0T7X9; O86345; Q50795;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 25-MAY-2022, entry version 43.
DE RecName: Full=Phosphate transport system permease protein PstA 1;
GN Name=pstA1; OrderedLocusNames=Rv0930; ORFNames=MTCY21C12.24;
OS Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83332;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 35801 / TMC 107 / Erdman;
RX PubMed=8112854; DOI=10.1128/iai.62.3.849-854.1994;
RA Braibant M., De Wit L., Peirs P., Kalai M., Ooms J., Drowart A., Huygen K.,
RA Content J.;
RT "Structure of the Mycobacterium tuberculosis antigen 88, a protein related
RT to the Escherichia coli PstA periplasmic phosphate permease subunit.";
RL Infect. Immun. 62:849-854(1994).
RN [2]
RP SEQUENCE REVISION.
RX PubMed=8843165; DOI=10.1016/0014-5793(96)00953-2;
RA Braibant M., Lefevre P., de Wit L., Ooms J., Peirs P., Huygen K.,
RA Wattiez R., Content J.;
RT "Identification of a second Mycobacterium tuberculosis gene cluster
RT encoding proteins of an ABC phosphate transporter.";
RL FEBS Lett. 394:206-212(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=9634230; DOI=10.1038/31159;
RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA Barrell B.G.;
RT "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT genome sequence.";
RL Nature 393:537-544(1998).
RN [4]
RP SEQUENCE REVISION.
RX PubMed=12368430; DOI=10.1099/00221287-148-10-2967;
RA Camus J.-C., Pryor M.J., Medigue C., Cole S.T.;
RT "Re-annotation of the genome sequence of Mycobacterium tuberculosis
RT H37Rv.";
RL Microbiology 148:2967-2973(2002).
RN [5]
RP FUNCTION, AND INDUCTION BY PHOSPHATE STARVATION.
RC STRAIN=H37Rv;
RX PubMed=20933472; DOI=10.1016/j.tube.2010.09.004;
RA Vanzembergh F., Peirs P., Lefevre P., Celio N., Mathys V., Content J.,
RA Kalai M.;
RT "Effect of PstS sub-units or PknD deficiency on the survival of
RT Mycobacterium tuberculosis.";
RL Tuberculosis 90:338-345(2010).
CC -!- FUNCTION: Part of the binding-protein-dependent transport system for
CC phosphate; probably responsible for the translocation of the substrate
CC across the membrane. {ECO:0000305|PubMed:20933472}.
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (PstB),
CC two transmembrane proteins (PstC and PstA) and a solute-binding protein
CC (PstS). {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- INDUCTION: 4-fold by phosphate starvation, part of the pstS3-pstC2-
CC pstA1 operon. {ECO:0000269|PubMed:20933472}.
CC -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC permease family. CysTW subfamily. {ECO:0000305}.
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DR EMBL; X75297; CAA53045.1; -; Genomic_DNA.
DR EMBL; AL123456; CCP43678.1; -; Genomic_DNA.
DR PIR; B70584; B70584.
DR RefSeq; NP_215445.2; NC_000962.3.
DR RefSeq; WP_010886095.1; NC_000962.3.
DR AlphaFoldDB; P9WG11; -.
DR SMR; P9WG11; -.
DR STRING; 83332.Rv0930; -.
DR PaxDb; P9WG11; -.
DR DNASU; 885589; -.
DR GeneID; 885589; -.
DR KEGG; mtu:Rv0930; -.
DR PATRIC; fig|83332.12.peg.1038; -.
DR TubercuList; Rv0930; -.
DR eggNOG; COG0581; Bacteria.
DR PhylomeDB; P9WG11; -.
DR PHI-base; PHI:3635; -.
DR Proteomes; UP000001584; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR GO; GO:0005315; F:inorganic phosphate transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0051701; P:biological process involved in interaction with host; IMP:MTBBASE.
DR GO; GO:0035435; P:phosphate ion transmembrane transport; IEA:InterPro.
DR CDD; cd06261; TM_PBP2; 1.
DR Gene3D; 1.10.3720.10; -; 1.
DR InterPro; IPR000515; MetI-like.
DR InterPro; IPR035906; MetI-like_sf.
DR InterPro; IPR005672; Phosphate_PstA.
DR Pfam; PF00528; BPD_transp_1; 1.
DR SUPFAM; SSF161098; SSF161098; 1.
DR TIGRFAMs; TIGR00974; 3a0107s02c; 1.
DR PROSITE; PS50928; ABC_TM1; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Membrane; Phosphate transport; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..308
FT /note="Phosphate transport system permease protein PstA 1"
FT /id="PRO_0000060201"
FT TRANSMEM 36..56
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 96..116
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 132..152
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 155..175
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 204..224
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 276..296
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 89..297
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT CONFLICT 5
FT /note="M -> T (in Ref. 1; CAA53045)"
FT /evidence="ECO:0000305"
FT CONFLICT 208
FT /note="V -> A (in Ref. 1; CAA53045)"
FT /evidence="ECO:0000305"
FT CONFLICT 305..308
FT /note="Missing (in Ref. 1; CAA53045)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 308 AA; 33498 MW; 085A5F2139FCD9E8 CRC64;
MSPSMSIEAL DQPVKPVVFR PLTLRRRIKN SVATTFFFTS FVVALIPLVW LLWVVIARGW
FAVTRSGWWT HSLRGVLPEQ FAGGVYHALY GTLVQAGVAA VLAVPLGLMT AVYLVEYGTG
RMSRVTTFTV DVLAGVPSIV AALFVFSLWI ATLGFQQSAF AVALALVLLM LPVVVRAGEE
MLRLVPDELR EASYALGVPK WKTIVRIVAP IAMPGIVSGI LLSIARVVGE TAPVLVLVGY
SHSINLDVFH GNMASLPLLI YTELTNPEHA GFLRVWGAAL TLIIVVATIN LAAAMIRFVA
TRRRRLPL
