ID   PSTA_MYCLE              Reviewed;         304 AA.
AC   Q50097;
DT   23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 113.
DE   RecName: Full=Phosphate transport system permease protein PstA;
GN   Name=pstA; Synonyms=phoX1, pstA1; OrderedLocusNames=ML2093;
OS   Mycobacterium leprae (strain TN).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=272631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Smith D.R., Robison K.;
RL   Submitted (SEP-1994) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TN;
RX   PubMed=11234002; DOI=10.1038/35059006;
RA   Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA   Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA   Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA   Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA   Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA   Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA   Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA   Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA   Barrell B.G.;
RT   "Massive gene decay in the leprosy bacillus.";
RL   Nature 409:1007-1011(2001).
CC   -!- FUNCTION: Part of the binding-protein-dependent transport system for
CC       phosphate; probably responsible for the translocation of the substrate
CC       across the membrane. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC       permease family. CysTW subfamily. {ECO:0000305}.
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DR   EMBL; U15184; AAA63078.1; -; Genomic_DNA.
DR   EMBL; AL583924; CAC31048.1; -; Genomic_DNA.
DR   PIR; H87170; H87170.
DR   RefSeq; NP_302393.1; NC_002677.1.
DR   RefSeq; WP_010908713.1; NC_002677.1.
DR   AlphaFoldDB; Q50097; -.
DR   SMR; Q50097; -.
DR   STRING; 272631.ML2093; -.
DR   EnsemblBacteria; CAC31048; CAC31048; CAC31048.
DR   KEGG; mle:ML2093; -.
DR   PATRIC; fig|272631.5.peg.3939; -.
DR   Leproma; ML2093; -.
DR   eggNOG; COG0581; Bacteria.
DR   HOGENOM; CLU_033621_2_0_11; -.
DR   OMA; GIARWKA; -.
DR   Proteomes; UP000000806; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR   GO; GO:0005315; F:inorganic phosphate transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0035435; P:phosphate ion transmembrane transport; IEA:InterPro.
DR   CDD; cd06261; TM_PBP2; 1.
DR   Gene3D; 1.10.3720.10; -; 1.
DR   InterPro; IPR000515; MetI-like.
DR   InterPro; IPR035906; MetI-like_sf.
DR   InterPro; IPR005672; Phosphate_PstA.
DR   Pfam; PF00528; BPD_transp_1; 1.
DR   SUPFAM; SSF161098; SSF161098; 1.
DR   TIGRFAMs; TIGR00974; 3a0107s02c; 1.
DR   PROSITE; PS50928; ABC_TM1; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Phosphate transport; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..304
FT                   /note="Phosphate transport system permease protein PstA"
FT                   /id="PRO_0000060200"
FT   TRANSMEM        32..52
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        92..112
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        128..148
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        151..171
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        200..220
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        272..292
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   DOMAIN          85..289
FT                   /note="ABC transmembrane type-1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
SQ   SEQUENCE   304 AA;  33310 MW;  5EAA094F4280848E CRC64;
     MNLDTLDRPV KAVVLRPISV RRRIKNNVAT MFFFTSFLIA LVPLVWLLSV VVARGFYAVT
     RFDWWTHSLR GVMPEEFAGG VYHALYGSLV QAVVAAIMAV PLGSMTAVYL VEYGSGPFVR
     VTTFMVDVLA GVPSIVAALF IFCLWIATLG FQQSAFAVSL ALVLLMLPVV VRSTEEILRL
     VPDELREACY ALGIPKWKTI VRIVFPIATP GIISGVLLSI ARVIGETAPV LVLVGYSRSI
     NFDIFDGNMA SLPLLIYTEL TNPEYAGFLR VWGAALTLII LVAGINLFGA AFRFLATRRC
     SGCR