ATO7A_XENLA
ID ATO7A_XENLA Reviewed; 138 AA.
AC O13125;
DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1997, sequence version 1.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=Transcription factor Atoh7-a {ECO:0000250|UniProtKB:Q9Z2E5};
DE AltName: Full=Atonal bHLH transcription factor 7-A {ECO:0000250|UniProtKB:Q9Z2E5};
DE AltName: Full=Helix-loop-helix protein xATH-5-A {ECO:0000303|PubMed:11401395};
DE AltName: Full=Protein atonal homolog 5-A {ECO:0000303|PubMed:9390513};
DE Short=xAth5-A {ECO:0000303|PubMed:9390513};
DE AltName: Full=Protein atonal homolog 7-A;
GN Name=atoh7-a {ECO:0000305}; Synonyms=ath5-a {ECO:0000305};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, AND FUNCTION IN RETINA
RP DEVELOPMENT.
RC TISSUE=Head;
RX PubMed=9390513; DOI=10.1016/s0896-6273(00)80391-8;
RA Kanekar S., Perron M., Dorsky R., Harris W.A., Jan L.Y., Jan Y.N.,
RA Vetter M.L.;
RT "Xath5 participates in a network of bHLH genes in the developing Xenopus
RT retina.";
RL Neuron 19:981-994(1997).
RN [2]
RP ERRATUM OF PUBMED:9390513.
RA Kanekar S., Perron M., Dorsky R., Harris W.A., Jan L.Y., Jan Y.N.,
RA Vetter M.L.;
RL Neuron 19:1221-1221(1997).
RN [3]
RP DEVELOPMENTAL STAGE, AND FUNCTION.
RX PubMed=11401395; DOI=10.1006/dbio.2001.0178;
RA Hutcheson D.A., Vetter M.L.;
RT "The bHLH factors Xath5 and XNeuroD can upregulate the expression of
RT XBrn3d, a POU-homeodomain transcription factor.";
RL Dev. Biol. 232:327-338(2001).
RN [4]
RP INHIBITION BY NOTCH AND ESR1.
RX PubMed=11922138; DOI=10.1006/mcne.2001.1040;
RA Schneider M.L., Turner D.L., Vetter M.L.;
RT "Notch signaling can inhibit Xath5 function in the neural plate and
RT developing retina.";
RL Mol. Cell. Neurosci. 18:458-472(2001).
RN [5]
RP FUNCTION IN OLFACTORY NEURON DEVELOPMENT, AND DEVELOPMENTAL STAGE.
RX PubMed=12454929; DOI=10.1002/dvdy.10189;
RA Burns C.J., Vetter M.L.;
RT "Xath5 regulates neurogenesis in the Xenopus olfactory placode.";
RL Dev. Dyn. 225:536-543(2002).
RN [6]
RP FUNCTION.
RX PubMed=16112102; DOI=10.1016/j.ydbio.2005.06.033;
RA Logan M.A., Steele M.R., Van Raay T.J., Vetter M.L.;
RT "Identification of shared transcriptional targets for the proneural bHLH
RT factors Xath5 and XNeuroD.";
RL Dev. Biol. 285:570-583(2005).
CC -!- FUNCTION: Transcription factor that binds to DNA at the consensus
CC sequence 5'-CAG[GC]TG-3' (By similarity). Positively regulates the
CC determination of retinal ganglion cell fate and formation of the optic
CC nerve and retino-hypothalamic tract (PubMed:9390513). Required for
CC retinal circadian rhythm photoentrainment (By similarity). Plays a role
CC in brainstem auditory signaling and binaural processing (By
CC similarity). Regulates the differentiation of olfactory receptor
CC neurons (PubMed:12454929). During retinal neurogenesis, activates the
CC transcription of several genes such as brn3d, coe3, cbfa2t2, glis2,
CC elrC and xgadd45-gamma (PubMed:11401395, PubMed:16112102).
CC {ECO:0000250|UniProtKB:Q9Z2E5, ECO:0000269|PubMed:11401395,
CC ECO:0000269|PubMed:12454929, ECO:0000269|PubMed:16112102,
CC ECO:0000269|PubMed:9390513}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8N100}.
CC Perikaryon {ECO:0000250|UniProtKB:Q9Z2E5}. Cell projection, axon
CC {ECO:0000250|UniProtKB:Q9Z2E5}.
CC -!- DEVELOPMENTAL STAGE: First detected at stage 17 as 2 symmetric patches
CC in the region of the presumptive olfactory placode. Expressed in the
CC pineal at stage 23, and in the eye starting from stage 24. By stage 27,
CC strongly expressed in retina, olfactory placodes and pineal. At stage
CC 32, expression strongly decreases in olfactory placodes and pineal but
CC is maintained in the neuroretina. At stage 41, expression is restricted
CC to the ciliary marginal zone of the retina.
CC {ECO:0000269|PubMed:11401395, ECO:0000269|PubMed:12454929,
CC ECO:0000269|PubMed:9390513}.
CC -!- MISCELLANEOUS: Inhibited by Notch and ESR1.
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DR EMBL; U93170; AAB58668.1; -; mRNA.
DR RefSeq; NP_001079289.1; NM_001085820.1.
DR AlphaFoldDB; O13125; -.
DR SMR; O13125; -.
DR GeneID; 378576; -.
DR KEGG; xla:378576; -.
DR CTD; 378576; -.
DR Xenbase; XB-GENE-6252646; atoh7.S.
DR OMA; QSPCPLR; -.
DR OrthoDB; 1453771at2759; -.
DR Proteomes; UP000186698; Chromosome 7S.
DR Bgee; 378576; Expressed in embryo and 1 other tissue.
DR GO; GO:0030424; C:axon; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0043204; C:perikaryon; ISS:UniProtKB.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; ISS:UniProtKB.
DR GO; GO:0003407; P:neural retina development; IEA:InterPro.
DR GO; GO:0048663; P:neuron fate commitment; TAS:AgBase.
DR GO; GO:1902336; P:positive regulation of retinal ganglion cell axon guidance; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR032663; ATOH7.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR PANTHER; PTHR19290:SF99; PTHR19290:SF99; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 1: Evidence at protein level;
KW Cell projection; Developmental protein; Differentiation; DNA-binding;
KW Neurogenesis; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..138
FT /note="Transcription factor Atoh7-a"
FT /id="PRO_0000292409"
FT DOMAIN 33..85
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
SQ SEQUENCE 138 AA; 16212 MW; 25363E84A6031730 CRC64;
MKSDSPVHRE SHTGCQSPCP LRCLPARLEG STKRRLAANA RERRRMQGLN TAFDSLRKVV
PQWGEDKQLS KYETLQMALS YIMALSRILS EAERYSRTDP EEWTNIQYDH IEEEQCLSYM
EVRCPRDCDR YLPQTFSH
