ID   ATOA_HAEIN              Reviewed;         223 AA.
AC   P44874;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=Acetate CoA-transferase subunit beta {ECO:0000250|UniProtKB:P76459};
DE            EC=2.8.3.8 {ECO:0000250|UniProtKB:P76459};
DE   AltName: Full=Acetyl-CoA:acetoacetate CoA-transferase subunit beta {ECO:0000250|UniProtKB:P76459};
GN   Name=atoA; OrderedLocusNames=HI_0773;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- FUNCTION: Coenzyme A transferase which is involved in short-chain fatty
CC       acid degradation and catalyzes the activation of short-chain fatty
CC       acids to their respective CoA thiolesters.
CC       {ECO:0000250|UniProtKB:P76459}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=acetate + an acyl-CoA = a carboxylate + acetyl-CoA;
CC         Xref=Rhea:RHEA:13381, ChEBI:CHEBI:29067, ChEBI:CHEBI:30089,
CC         ChEBI:CHEBI:57288, ChEBI:CHEBI:58342; EC=2.8.3.8;
CC         Evidence={ECO:0000250|UniProtKB:P76459};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=acetoacetate + acetyl-CoA = acetate + acetoacetyl-CoA;
CC         Xref=Rhea:RHEA:27806, ChEBI:CHEBI:13705, ChEBI:CHEBI:30089,
CC         ChEBI:CHEBI:57286, ChEBI:CHEBI:57288;
CC         Evidence={ECO:0000250|UniProtKB:P76459};
CC   -!- PATHWAY: Lipid metabolism; short-chain fatty acid metabolism.
CC       {ECO:0000250|UniProtKB:P76459}.
CC   -!- SUBUNIT: Heterotetramer composed of two alpha subunits (AtoD) and two
CC       beta subunits (AtoA). {ECO:0000250|UniProtKB:P76459}.
CC   -!- SIMILARITY: Belongs to the 3-oxoacid CoA-transferase subunit B family.
CC       {ECO:0000305}.
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DR   EMBL; L42023; AAC22432.1; -; Genomic_DNA.
DR   PIR; G64158; G64158.
DR   RefSeq; NP_438932.1; NC_000907.1.
DR   RefSeq; WP_005693164.1; NC_000907.1.
DR   AlphaFoldDB; P44874; -.
DR   SMR; P44874; -.
DR   STRING; 71421.HI_0773; -.
DR   EnsemblBacteria; AAC22432; AAC22432; HI_0773.
DR   KEGG; hin:HI_0773; -.
DR   PATRIC; fig|71421.8.peg.812; -.
DR   eggNOG; COG2057; Bacteria.
DR   HOGENOM; CLU_019942_4_1_6; -.
DR   OMA; NWMVPGS; -.
DR   PhylomeDB; P44874; -.
DR   BioCyc; HINF71421:G1GJ1-813-MON; -.
DR   UniPathway; UPA00656; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0008775; F:acetate CoA-transferase activity; IBA:GO_Central.
DR   GO; GO:0008410; F:CoA-transferase activity; IBA:GO_Central.
DR   GO; GO:0046459; P:short-chain fatty acid metabolic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR012791; 3-oxoacid_CoA-transf_B.
DR   InterPro; IPR004165; CoA_trans_fam_I.
DR   InterPro; IPR004164; CoA_transf_AS.
DR   InterPro; IPR037171; NagB/RpiA_transferase-like.
DR   PANTHER; PTHR13707; PTHR13707; 1.
DR   Pfam; PF01144; CoA_trans; 1.
DR   SMART; SM00882; CoA_trans; 1.
DR   SUPFAM; SSF100950; SSF100950; 1.
DR   TIGRFAMs; TIGR02428; pcaJ_scoB_fam; 1.
DR   PROSITE; PS01274; COA_TRANSF_2; 1.
PE   3: Inferred from homology;
KW   Fatty acid metabolism; Lipid metabolism; Reference proteome; Transferase.
FT   CHAIN           1..223
FT                   /note="Acetate CoA-transferase subunit beta"
FT                   /id="PRO_0000157916"
FT   ACT_SITE        46
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10034"
SQ   SEQUENCE   223 AA;  23750 MW;  EC56D6684708C851 CRC64;
     MNAKELIARR IAMELHDGDI VNLGIGLPTQ VVNYLPDNVN ITLQSENGFL GLTAFDPENA
     NSNLVNAGGQ PCGIKKGGST FDSAFSFALI RGGHVDACVL GGLEVDQEAN LANWMVPGKM
     VPGMGGAMDL VTGAKKVIIG MEHCAKSGSS KILKKCTLPL TASKKVAMVV TELAVFNFIE
     GRLVLKEHAP HVDLETIKAK TEADFIVADD FKEMQISQKG LEL