ID   ATOD_HAEIN              Reviewed;         217 AA.
AC   P44875;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=Acetate CoA-transferase subunit alpha {ECO:0000250|UniProtKB:P76458};
DE            EC=2.8.3.8 {ECO:0000250|UniProtKB:P76458};
DE   AltName: Full=Acetyl-CoA:acetoacetate-CoA transferase subunit alpha {ECO:0000250|UniProtKB:P76458};
GN   Name=atoD; OrderedLocusNames=HI_0774;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- FUNCTION: Coenzyme A transferase which is involved in short-chain fatty
CC       acid degradation and catalyzes the activation of short-chain fatty
CC       acids to their respective CoA thiolesters.
CC       {ECO:0000250|UniProtKB:P76458}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=acetate + an acyl-CoA = a carboxylate + acetyl-CoA;
CC         Xref=Rhea:RHEA:13381, ChEBI:CHEBI:29067, ChEBI:CHEBI:30089,
CC         ChEBI:CHEBI:57288, ChEBI:CHEBI:58342; EC=2.8.3.8;
CC         Evidence={ECO:0000250|UniProtKB:P76458};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=acetoacetate + acetyl-CoA = acetate + acetoacetyl-CoA;
CC         Xref=Rhea:RHEA:27806, ChEBI:CHEBI:13705, ChEBI:CHEBI:30089,
CC         ChEBI:CHEBI:57286, ChEBI:CHEBI:57288;
CC         Evidence={ECO:0000250|UniProtKB:P76458};
CC   -!- PATHWAY: Lipid metabolism; short-chain fatty acid metabolism.
CC       {ECO:0000250|UniProtKB:P76458}.
CC   -!- SUBUNIT: Heterotetramer composed of two alpha subunits (AtoD) and two
CC       beta subunits (AtoA). {ECO:0000250|UniProtKB:P76458}.
CC   -!- SIMILARITY: Belongs to the 3-oxoacid CoA-transferase subunit A family.
CC       {ECO:0000305}.
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DR   EMBL; L42023; AAC22433.1; -; Genomic_DNA.
DR   PIR; B64092; B64092.
DR   RefSeq; NP_438933.1; NC_000907.1.
DR   RefSeq; WP_005693165.1; NC_000907.1.
DR   AlphaFoldDB; P44875; -.
DR   SMR; P44875; -.
DR   STRING; 71421.HI_0774; -.
DR   EnsemblBacteria; AAC22433; AAC22433; HI_0774.
DR   KEGG; hin:HI_0774; -.
DR   PATRIC; fig|71421.8.peg.813; -.
DR   eggNOG; COG1788; Bacteria.
DR   HOGENOM; CLU_019942_2_1_6; -.
DR   OMA; QLAPECI; -.
DR   PhylomeDB; P44875; -.
DR   BioCyc; HINF71421:G1GJ1-814-MON; -.
DR   UniPathway; UPA00656; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0008775; F:acetate CoA-transferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008410; F:CoA-transferase activity; IBA:GO_Central.
DR   GO; GO:0046459; P:short-chain fatty acid metabolic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR012792; 3-oxoacid_CoA-transf_A.
DR   InterPro; IPR004165; CoA_trans_fam_I.
DR   InterPro; IPR004163; CoA_transf_BS.
DR   InterPro; IPR037171; NagB/RpiA_transferase-like.
DR   PANTHER; PTHR13707; PTHR13707; 1.
DR   Pfam; PF01144; CoA_trans; 1.
DR   SMART; SM00882; CoA_trans; 1.
DR   SUPFAM; SSF100950; SSF100950; 1.
DR   TIGRFAMs; TIGR02429; pcaI_scoA_fam; 1.
DR   PROSITE; PS01273; COA_TRANSF_1; 1.
PE   3: Inferred from homology;
KW   Fatty acid metabolism; Lipid metabolism; Reference proteome; Transferase.
FT   CHAIN           1..217
FT                   /note="Acetate CoA-transferase subunit alpha"
FT                   /id="PRO_0000157905"
FT   BINDING         24..30
FT                   /ligand="CoA"
FT                   /ligand_id="ChEBI:CHEBI:57287"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   217 AA;  23090 MW;  6FAA18F32047F910 CRC64;
     MTQKHLKLNN LNQHLHDGMS IMFGGFMGIG TPAKLVQQIL DSGVKDLTLI GNDTAFIDTG
     VGPLIVNNRV KRLITSHIGT NPETGKKMIA GEIDVELVPQ GTLAERIRAG GAGLGGILTP
     TGVGTVVEEG KQKIQIDGRE YLLELPLKAD IAIIHAQKGD MNGNLAYELS ARNFNPLVAL
     AAKTVIAQVD NLLEVGQLPP DEVITPAALI DYIVCSE