ATOH1_MOUSE
ID ATOH1_MOUSE Reviewed; 351 AA.
AC P48985;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 03-AUG-2022, entry version 161.
DE RecName: Full=Transcription factor Atoh1 {ECO:0000305};
DE AltName: Full=Atonal bHLH transcription factor 1 {ECO:0000312|MGI:MGI:104654};
DE AltName: Full=Helix-loop-helix protein mATH-1 {ECO:0000303|PubMed:7721778};
DE Short=mATH1 {ECO:0000303|PubMed:7721778};
DE AltName: Full=Protein atonal homolog 1 {ECO:0000312|MGI:MGI:104654};
GN Name=Atoh1 {ECO:0000312|MGI:MGI:104654}; Synonyms=Ath1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP STAGE.
RC STRAIN=129/J;
RX PubMed=7721778; DOI=10.1074/jbc.270.15.8730;
RA Akazawa C., Ishibashi M., Shimizu C., Nakanishi S., Kageyama R.;
RT "A mammalian helix-loop-helix factor structurally related to the product of
RT Drosophila proneural gene atonal is a positive transcriptional regulator
RT expressed in the developing nervous system.";
RL J. Biol. Chem. 270:8730-8738(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=10648228; DOI=10.1242/dev.127.4.693;
RA Farah M.H., Olson J.M., Sucic H.B., Hume R.I., Tapscott S.J., Turner D.L.;
RT "Generation of neurons by transient expression of neural bHLH proteins in
RT mammalian cells.";
RL Development 127:693-702(2000).
RN [4]
RP DEVELOPMENTAL STAGE.
RX PubMed=17977745; DOI=10.1016/j.mcn.2007.09.006;
RA Saul S.M., Brzezinski J.A. IV, Altschuler R.A., Shore S.E., Rudolph D.D.,
RA Kabara L.L., Halsey K.E., Hufnagel R.B., Zhou J., Dolan D.F., Glaser T.;
RT "Math5 expression and function in the central auditory system.";
RL Mol. Cell. Neurosci. 37:153-169(2008).
CC -!- FUNCTION: Transcriptional regulator. Activates E box-dependent
CC transcription in collaboration with TCF3/E47, but the activity is
CC completely antagonized by the negative regulator of neurogenesis HES1.
CC Plays a role in the differentiation of subsets of neural cells by
CC activating E box-dependent transcription.
CC {ECO:0000269|PubMed:10648228}.
CC -!- SUBUNIT: Efficient DNA binding requires dimerization with another bHLH
CC protein.
CC -!- INTERACTION:
CC P48985; Q91YV0: Tcf4; NbExp=2; IntAct=EBI-15659000, EBI-15658970;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981,
CC ECO:0000269|PubMed:10648228}.
CC -!- TISSUE SPECIFICITY: Developing nervous system, and in adult epithelial
CC cells of the gastrointestinal tract. {ECO:0000269|PubMed:7721778}.
CC -!- DEVELOPMENTAL STAGE: First detected in the cranial ganglions and the
CC dorsal part of the central nervous system on 9.5 dpc (PubMed:7721778).
CC From 10.5 dpc onward, prominently expressed in the dorsal part of the
CC central nervous system but becomes restricted to the external granular
CC layer of the cerebellum by 18 dpc and is undetectable in the adult
CC nervous system (PubMed:7721778). Expressed in the cochlear nucleus at
CC 15.5 dpc (PubMed:17977745). {ECO:0000269|PubMed:17977745,
CC ECO:0000269|PubMed:7721778}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; D43694; BAA07791.1; -; Genomic_DNA.
DR EMBL; BC010820; AAH10820.1; -; mRNA.
DR EMBL; BC051256; AAH51256.1; -; mRNA.
DR CCDS; CCDS20203.1; -.
DR PIR; A56387; A56387.
DR RefSeq; NP_031526.1; NM_007500.4.
DR AlphaFoldDB; P48985; -.
DR SMR; P48985; -.
DR BioGRID; 198237; 1.
DR DIP; DIP-46434N; -.
DR IntAct; P48985; 3.
DR STRING; 10090.ENSMUSP00000098903; -.
DR iPTMnet; P48985; -.
DR PhosphoSitePlus; P48985; -.
DR PaxDb; P48985; -.
DR PRIDE; P48985; -.
DR ProteomicsDB; 265154; -.
DR Antibodypedia; 25709; 568 antibodies from 32 providers.
DR DNASU; 11921; -.
DR Ensembl; ENSMUST00000101351; ENSMUSP00000098903; ENSMUSG00000073043.
DR GeneID; 11921; -.
DR KEGG; mmu:11921; -.
DR UCSC; uc009ceb.2; mouse.
DR CTD; 474; -.
DR MGI; MGI:104654; Atoh1.
DR VEuPathDB; HostDB:ENSMUSG00000073043; -.
DR eggNOG; KOG4395; Eukaryota.
DR GeneTree; ENSGT00940000160064; -.
DR HOGENOM; CLU_083039_0_0_1; -.
DR InParanoid; P48985; -.
DR OMA; SCKNDHH; -.
DR OrthoDB; 926106at2759; -.
DR PhylomeDB; P48985; -.
DR TreeFam; TF315153; -.
DR BioGRID-ORCS; 11921; 0 hits in 73 CRISPR screens.
DR PRO; PR:P48985; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; P48985; protein.
DR Bgee; ENSMUSG00000073043; Expressed in cerebellum external granule cell layer and 75 other tissues.
DR Genevisible; P48985; MM.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0031490; F:chromatin DNA binding; IDA:MGI.
DR GO; GO:0003677; F:DNA binding; IDA:MGI.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:NTNU_SB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:NTNU_SB.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:MGI.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0042668; P:auditory receptor cell fate determination; IDA:MGI.
DR GO; GO:0042667; P:auditory receptor cell fate specification; IMP:MGI.
DR GO; GO:0007411; P:axon guidance; IMP:MGI.
DR GO; GO:0007420; P:brain development; IMP:MGI.
DR GO; GO:0030154; P:cell differentiation; IMP:MGI.
DR GO; GO:0021987; P:cerebral cortex development; IMP:MGI.
DR GO; GO:1904019; P:epithelial cell apoptotic process; IMP:MGI.
DR GO; GO:0042491; P:inner ear auditory receptor cell differentiation; IDA:MGI.
DR GO; GO:0048839; P:inner ear development; IMP:MGI.
DR GO; GO:0042472; P:inner ear morphogenesis; IMP:MGI.
DR GO; GO:1904036; P:negative regulation of epithelial cell apoptotic process; IMP:MGI.
DR GO; GO:0014014; P:negative regulation of gliogenesis; IGI:UniProtKB.
DR GO; GO:0097402; P:neuroblast migration; IMP:MGI.
DR GO; GO:0030182; P:neuron differentiation; IMP:MGI.
DR GO; GO:0001764; P:neuron migration; IMP:MGI.
DR GO; GO:0007219; P:Notch signaling pathway; IDA:MGI.
DR GO; GO:0045609; P:positive regulation of inner ear auditory receptor cell differentiation; IDA:MGI.
DR GO; GO:2000982; P:positive regulation of inner ear receptor cell differentiation; IMP:UniProtKB.
DR GO; GO:0045666; P:positive regulation of neuron differentiation; IDA:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:NTNU_SB.
DR GO; GO:0045664; P:regulation of neuron differentiation; IDA:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006366; P:transcription by RNA polymerase II; IMP:MGI.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR032661; ATOH1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR PANTHER; PTHR19290:SF82; PTHR19290:SF82; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 1: Evidence at protein level;
KW Activator; Developmental protein; Differentiation; DNA-binding;
KW Neurogenesis; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..351
FT /note="Transcription factor Atoh1"
FT /id="PRO_0000127140"
FT DOMAIN 156..208
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 16..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 89..116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 244..278
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 308..351
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 326..351
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 351 AA; 37854 MW; 596E03DF23C3BF96 CRC64;
MSRLLHAEEW AEVKELGDHH RHPQPHHVPP LTPQPPATLQ ARDLPVYPAE LSLLDSTDPR
AWLTPTLQGL CTARAAQYLL HSPELGASEA AAPRDEADSQ GELVRRSGCG GLSKSPGPVK
VREQLCKLKG GVVVDELGCS RQRAPSSKQV NGVQKQRRLA ANARERRRMH GLNHAFDQLR
NVIPSFNNDK KLSKYETLQM AQIYINALSE LLQTPNVGEQ PPPPTASCKN DHHHLRTASS
YEGGAGASAV AGAQPAPGGG PRPTPPGPCR TRFSGPASSG GYSVQLDALH FPAFEDRALT
AMMAQKDLSP SLPGGILQPV QEDNSKTSPR SHRSDGEFSP HSHYSDSDEA S
