ATOH1_PANTR
ID ATOH1_PANTR Reviewed; 356 AA.
AC Q5IS79;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=Transcription factor ATOH1 {ECO:0000250|UniProtKB:Q92858};
DE AltName: Full=Atonal bHLH transcription factor 1 {ECO:0000250|UniProtKB:Q92858};
DE AltName: Full=Protein atonal homolog 1 {ECO:0000250|UniProtKB:Q92858};
GN Name=ATOH1 {ECO:0000250|UniProtKB:Q92858};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=15620360; DOI=10.1016/j.cell.2004.11.040;
RA Dorus S., Vallender E.J., Evans P.D., Anderson J.R., Gilbert S.L.,
RA Mahowald M., Wyckoff G.J., Malcom C.M., Lahn B.T.;
RT "Accelerated evolution of nervous system genes in the origin of Homo
RT sapiens.";
RL Cell 119:1027-1040(2004).
CC -!- FUNCTION: Transcriptional regulator. Activates E box-dependent
CC transcription in collaboration with TCF3/E47, but the activity is
CC completely antagonized by the negative regulator of neurogenesis HES1.
CC Plays a role in the differentiation of subsets of neural cells by
CC activating E box-dependent transcription (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Efficient DNA binding requires dimerization with another bHLH
CC protein. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
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DR EMBL; AY665249; AAV74287.1; -; mRNA.
DR RefSeq; NP_001012434.1; NM_001012432.1.
DR AlphaFoldDB; Q5IS79; -.
DR SMR; Q5IS79; -.
DR STRING; 9598.ENSPTRP00000053413; -.
DR PaxDb; Q5IS79; -.
DR Ensembl; ENSPTRT00000060114; ENSPTRP00000053413; ENSPTRG00000031141.
DR GeneID; 461380; -.
DR KEGG; ptr:461380; -.
DR CTD; 474; -.
DR VGNC; VGNC:568; ATOH1.
DR eggNOG; KOG4395; Eukaryota.
DR GeneTree; ENSGT00940000160064; -.
DR InParanoid; Q5IS79; -.
DR OMA; SCKNDHH; -.
DR OrthoDB; 926106at2759; -.
DR Proteomes; UP000002277; Chromosome 4.
DR Bgee; ENSPTRG00000031141; Expressed in cerebellar cortex and 1 other tissue.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0031490; F:chromatin DNA binding; IEA:Ensembl.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0042668; P:auditory receptor cell fate determination; IEA:Ensembl.
DR GO; GO:0042667; P:auditory receptor cell fate specification; IEA:Ensembl.
DR GO; GO:0007411; P:axon guidance; IEA:Ensembl.
DR GO; GO:0021987; P:cerebral cortex development; IEA:Ensembl.
DR GO; GO:1904019; P:epithelial cell apoptotic process; IEA:Ensembl.
DR GO; GO:0042472; P:inner ear morphogenesis; IEA:Ensembl.
DR GO; GO:1904036; P:negative regulation of epithelial cell apoptotic process; IEA:Ensembl.
DR GO; GO:0014014; P:negative regulation of gliogenesis; IEA:Ensembl.
DR GO; GO:0097402; P:neuroblast migration; IEA:Ensembl.
DR GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR GO; GO:0001764; P:neuron migration; IEA:Ensembl.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:Ensembl.
DR GO; GO:0045609; P:positive regulation of inner ear auditory receptor cell differentiation; IEA:Ensembl.
DR GO; GO:0045666; P:positive regulation of neuron differentiation; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006366; P:transcription by RNA polymerase II; IEA:Ensembl.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR032661; ATOH1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR PANTHER; PTHR19290:SF82; PTHR19290:SF82; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 2: Evidence at transcript level;
KW Activator; Developmental protein; Differentiation; DNA-binding;
KW Neurogenesis; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..356
FT /note="Transcription factor ATOH1"
FT /id="PRO_0000127141"
FT DOMAIN 161..213
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 1..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 92..125
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 218..279
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 314..356
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..25
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 26..43
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 255..273
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 314..330
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 331..356
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 356 AA; 38385 MW; 9C02375813F943DC CRC64;
MSRLLHAEEW AEVKELGDHH RQPQPHHLPQ PPPPPPPQPP ATLQAREHPV YPPELSLLDS
TDPRAWLAPT LQGICTARAA QYLLHSPELS ASEAAAPRDE VDGRGELVRR SSGGASSSKS
PGPVKVREQL CKLKGGVVVD ELGCSRQRAP SSKQVNGVQK QRRLAANARE RRRMHGLNHA
FDQLRNVIPS FNNDKKLSKY ETLQMAQIYI NALSELLQTP SGGEQPPPPP ASCKSDHHHL
RTAASYEGGA GNATAAGAQQ ASGGSQRPTP PGSCRTRFSA PASAGGYSVQ LDALHFSTFE
DSALTAMMAQ KNLSPSLPGS ILQPVQEENS KTSPRSHRSD GEFSPHSHYS DSDEAS
