ID   ATOH7_CHICK             Reviewed;         151 AA.
AC   O57598;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 2.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=Transcription factor ATOH7 {ECO:0000305};
DE   AltName: Full=Atonal bHLH transcription factor 7 {ECO:0000250|UniProtKB:Q8N100};
DE   AltName: Full=Helix-loop-helix protein cATH-5 {ECO:0000303|PubMed:11172005};
DE            Short=cATH5 {ECO:0000303|PubMed:11172005};
DE   AltName: Full=Protein atonal homolog 5 {ECO:0000303|PubMed:11124117};
DE   AltName: Full=Protein atonal homolog 7 {ECO:0000250|UniProtKB:Q8N100};
GN   Name=ATOH7 {ECO:0000250|UniProtKB:Q9Z2E5};
GN   Synonyms=ATH5 {ECO:0000303|PubMed:11124117};
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], DEVELOPMENTAL STAGE, AND
RP   FUNCTION.
RC   TISSUE=Blood, and Neuroretina;
RX   PubMed=11124117; DOI=10.1242/dev.128.2.217;
RA   Matter-Sadzinski L., Matter J.-M., Ong M.-T., Hernandez J., Ballivet M.;
RT   "Specification of neurotransmitter receptor identity in developing retina:
RT   the chick ATH5 promoter integrates the positive and negative effects of
RT   several bHLH proteins.";
RL   Development 128:217-231(2001).
RN   [2]
RP   FUNCTION, AND DEVELOPMENTAL STAGE.
RX   PubMed=11172005; DOI=10.1073/pnas.98.4.1649;
RA   Liu W., Mo Z., Xiang M.;
RT   "The Ath5 proneural genes function upstream of Brn3 POU domain
RT   transcription factor genes to promote retinal ganglion cell development.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:1649-1654(2001).
RN   [3]
RP   FUNCTION, AND DNA-BINDING.
RX   PubMed=15342472; DOI=10.1242/dev.01302;
RA   Skowronska-Krawczyk D., Ballivet M., Dynlacht B.D., Matter J.-M.;
RT   "Highly specific interactions between bHLH transcription factors and
RT   chromatin during retina development.";
RL   Development 131:4447-4454(2004).
RN   [4]
RP   INDUCTION.
RX   PubMed=16079155; DOI=10.1242/dev.01960;
RA   Matter-Sadzinski L., Puzianowska-Kuznicka M., Hernandez J., Ballivet M.,
RA   Matter J.-M.;
RT   "A bHLH transcriptional network regulating the specification of retinal
RT   ganglion cells.";
RL   Development 132:3907-3921(2005).
RN   [5]
RP   FUNCTION.
RX   PubMed=16260616; DOI=10.1128/mcb.25.22.10029-10039.2005;
RA   Skowronska-Krawczyk D., Matter-Sadzinski L., Ballivet M., Matter J.-M.;
RT   "The basic domain of ATH5 mediates neuron-specific promoter activity during
RT   retina development.";
RL   Mol. Cell. Biol. 25:10029-10039(2005).
CC   -!- FUNCTION: Transcription factor that binds to DNA at the consensus
CC       sequence 5'-CAG[GC]TG-3' (By similarity). Positively regulates the
CC       determination of retinal ganglion cell fate and formation of the optic
CC       nerve and retino-hypothalamic tract (PubMed:11124117, PubMed:15342472,
CC       PubMed:16260616). Required for retinal circadian rhythm
CC       photoentrainment (By similarity). Plays a role in brainstem auditory
CC       signaling and binaural processing (By similarity). During retinal
CC       neurogenesis, activates its own transcription, as well as the
CC       transcription of CHRNB3 and BRN3 (PubMed:11172005).
CC       {ECO:0000250|UniProtKB:Q9Z2E5, ECO:0000269|PubMed:11124117,
CC       ECO:0000269|PubMed:11172005, ECO:0000269|PubMed:15342472,
CC       ECO:0000269|PubMed:16260616}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8N100}.
CC       Perikaryon {ECO:0000250|UniProtKB:Q9Z2E5}. Cell projection, axon
CC       {ECO:0000250|UniProtKB:Q9Z2E5}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in the developing retina, and in a tiny
CC       population of ventricular cells located in the ventral domain of the
CC       spinal cord and hindbrain. Retinal expression peaks at stage 29 (E6).
CC       {ECO:0000269|PubMed:11124117, ECO:0000269|PubMed:11172005}.
CC   -!- INDUCTION: Up-regulated by NGN2 and ATOH7. Down-regulated by HES1.
CC       {ECO:0000269|PubMed:16079155}.
CC   -!- DOMAIN: The basic motif confers specificity for the CHRNB3 promoter.
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DR   EMBL; AJ001178; CAA04572.1; -; mRNA.
DR   EMBL; AJ630209; CAF34420.1; -; Genomic_DNA.
DR   RefSeq; NP_989999.1; NM_204668.1.
DR   AlphaFoldDB; O57598; -.
DR   SMR; O57598; -.
DR   STRING; 9031.ENSGALP00000040088; -.
DR   PaxDb; O57598; -.
DR   Ensembl; ENSGALT00000091265; ENSGALP00000065463; ENSGALG00000052760.
DR   GeneID; 395388; -.
DR   KEGG; gga:395388; -.
DR   CTD; 220202; -.
DR   VEuPathDB; HostDB:geneid_395388; -.
DR   eggNOG; KOG4395; Eukaryota.
DR   GeneTree; ENSGT00940000161556; -.
DR   HOGENOM; CLU_145503_0_0_1; -.
DR   InParanoid; O57598; -.
DR   OMA; WVSLHCE; -.
DR   OrthoDB; 1453771at2759; -.
DR   PhylomeDB; O57598; -.
DR   TreeFam; TF315153; -.
DR   PRO; PR:O57598; -.
DR   Proteomes; UP000000539; Chromosome 6.
DR   GO; GO:0030424; C:axon; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0043204; C:perikaryon; ISS:UniProtKB.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; ISS:UniProtKB.
DR   GO; GO:0007623; P:circadian rhythm; IEA:Ensembl.
DR   GO; GO:0043153; P:entrainment of circadian clock by photoperiod; IEA:Ensembl.
DR   GO; GO:0003407; P:neural retina development; IMP:AgBase.
DR   GO; GO:0030182; P:neuron differentiation; IMP:AgBase.
DR   GO; GO:0048663; P:neuron fate commitment; TAS:AgBase.
DR   GO; GO:0021554; P:optic nerve development; IEA:Ensembl.
DR   GO; GO:1902336; P:positive regulation of retinal ganglion cell axon guidance; ISS:UniProtKB.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   GO; GO:0010996; P:response to auditory stimulus; ISS:UniProtKB.
DR   Gene3D; 4.10.280.10; -; 1.
DR   InterPro; IPR032663; ATOH7.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   PANTHER; PTHR19290:SF99; PTHR19290:SF99; 1.
DR   Pfam; PF00010; HLH; 1.
DR   SMART; SM00353; HLH; 1.
DR   SUPFAM; SSF47459; SSF47459; 1.
DR   PROSITE; PS50888; BHLH; 1.
PE   1: Evidence at protein level;
KW   Cell projection; Developmental protein; Differentiation; DNA-binding;
KW   Neurogenesis; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000305"
FT   CHAIN           2..151
FT                   /note="Transcription factor ATOH7"
FT                   /id="PRO_5000064266"
FT   DOMAIN          39..91
FT                   /note="bHLH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT   SITE            42..43
FT                   /note="Required for CHRNB3 transcription activation but not
FT                   for DNA binding"
FT   SITE            49
FT                   /note="Required for CHRNB3 transcription activation but not
FT                   for DNA binding"
SQ   SEQUENCE   151 AA;  17540 MW;  1D4F2F9D225A5319 CRC64;
     MKTCQSSHLD SGVESDIQCR SGSGCVVKCS TERMESAAKR RLAANARERR RMQGLNTAFD
     RLRKVVPQWG QDKKLSKYET LQMALSYIMA LTRILAEAER YSTEREWINL HCEHFHPESY
     HHYTGQKVAT DSDPYAQRIF SYHPEHFQIA N