ATOH7_DANRE
ID ATOH7_DANRE Reviewed; 134 AA.
AC Q8AW52; Q9DGA9;
DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Transcription factor atoh7 {ECO:0000305};
DE AltName: Full=Atonal bHLH transcription factor 7 {ECO:0000250|UniProtKB:Q9Z2E5};
DE AltName: Full=Helix-loop-helix protein zATH-5 {ECO:0000305};
DE Short=zATH5 {ECO:0000305};
DE AltName: Full=Protein atonal homolog 5 {ECO:0000305};
DE AltName: Full=Protein atonal homolog 7 {ECO:0000250|UniProtKB:Q8N100};
DE AltName: Full=Protein lakritz {ECO:0000303|PubMed:11430806};
GN Name=atoh7 {ECO:0000250|UniProtKB:Q9Z2E5};
GN Synonyms=ath5 {ECO:0000305}, lak {ECO:0000303|PubMed:11430806};
GN ORFNames=si:packtrz.1;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, AND FUNCTION.
RX PubMed=10985346; DOI=10.1016/s0896-6273(00)00034-9;
RA Masai I., Stemple D.L., Okamoto H., Wilson S.W.;
RT "Midline signals regulate retinal neurogenesis in zebrafish.";
RL Neuron 27:251-263(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP FUNCTION, AND MUTAGENESIS OF LEU-44.
RX PubMed=11430806; DOI=10.1016/s0896-6273(01)00312-9;
RA Kay J.N., Finger-Baier K.C., Roeser T., Staub W., Baier H.;
RT "Retinal ganglion cell genesis requires lakritz, a zebrafish atonal
RT homolog.";
RL Neuron 30:725-736(2001).
CC -!- FUNCTION: Transcription factor that binds to DNA at the consensus
CC sequence 5'-CAG[GC]TG-3' (By similarity). Involved in the
CC differentiation of retinal ganglion cells, photoreceptor population and
CC optic nerve development (PubMed:10985346, PubMed:11430806). Required
CC for retinal circadian rhythm photoentrainment (By similarity).
CC {ECO:0000250|UniProtKB:Q9Z2E5, ECO:0000269|PubMed:10985346,
CC ECO:0000269|PubMed:11430806}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8N100}.
CC Perikaryon {ECO:0000250|UniProtKB:Q9Z2E5}. Cell projection, axon
CC {ECO:0000250|UniProtKB:Q9Z2E5}.
CC -!- DEVELOPMENTAL STAGE: Expressed in the developing retina.
CC {ECO:0000269|PubMed:10985346}.
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DR EMBL; AB049457; BAB15953.1; -; mRNA.
DR EMBL; AL627094; CAD52125.1; -; Genomic_DNA.
DR EMBL; BC071520; AAH71520.1; -; mRNA.
DR RefSeq; NP_571707.1; NM_131632.1.
DR AlphaFoldDB; Q8AW52; -.
DR SMR; Q8AW52; -.
DR STRING; 7955.ENSDARP00000092102; -.
DR PaxDb; Q8AW52; -.
DR Ensembl; ENSDART00000101328; ENSDARP00000092102; ENSDARG00000069552.
DR GeneID; 58216; -.
DR KEGG; dre:58216; -.
DR CTD; 220202; -.
DR ZFIN; ZDB-GENE-000926-1; atoh7.
DR eggNOG; KOG4395; Eukaryota.
DR GeneTree; ENSGT00940000161556; -.
DR HOGENOM; CLU_145503_0_0_1; -.
DR InParanoid; Q8AW52; -.
DR OMA; YPCLMRY; -.
DR OrthoDB; 1453771at2759; -.
DR PhylomeDB; Q8AW52; -.
DR TreeFam; TF315153; -.
DR PRO; PR:Q8AW52; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 13.
DR Bgee; ENSDARG00000069552; Expressed in optic cup and 6 other tissues.
DR GO; GO:0030424; C:axon; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0043204; C:perikaryon; ISS:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; ISS:UniProtKB.
DR GO; GO:0043010; P:camera-type eye development; IMP:ZFIN.
DR GO; GO:0045165; P:cell fate commitment; IMP:ZFIN.
DR GO; GO:0001654; P:eye development; IMP:ZFIN.
DR GO; GO:0003407; P:neural retina development; IMP:ZFIN.
DR GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR GO; GO:0043473; P:pigmentation; IMP:ZFIN.
DR GO; GO:0050769; P:positive regulation of neurogenesis; IMP:ZFIN.
DR GO; GO:1902336; P:positive regulation of retinal ganglion cell axon guidance; ISS:UniProtKB.
DR GO; GO:0051726; P:regulation of cell cycle; IMP:ZFIN.
DR GO; GO:0007346; P:regulation of mitotic cell cycle; IMP:ZFIN.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0060041; P:retina development in camera-type eye; IMP:ZFIN.
DR GO; GO:0010842; P:retina layer formation; IMP:ZFIN.
DR GO; GO:0036269; P:swimming behavior; IMP:ZFIN.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 1: Evidence at protein level;
KW Cell projection; Developmental protein; Differentiation; DNA-binding;
KW Neurogenesis; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..134
FT /note="Transcription factor atoh7"
FT /id="PRO_0000292408"
FT DOMAIN 28..80
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MUTAGEN 44
FT /note="L->P: In th241; no retinal ganglion cells."
FT /evidence="ECO:0000269|PubMed:11430806"
FT CONFLICT 123
FT /note="M -> T (in Ref. 1; BAB15953)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 134 AA; 15622 MW; 3207DBD0E5972496 CRC64;
MKPRRPSCAD SGSDSDSRDP EKFESAMRRR MAANARERKR MQGLNTAFDR LRKVVPQWGQ
DKKLSKYETL QMALSYIMAL NRILSDAGRH VDPQKDWLNL QFDGLQTEGY FMHYDSPVES
DCMLSSFSYH YESL
