ID   ATOX1_BACCR             Reviewed;         117 AA.
AC   Q81H98;
DT   16-OCT-2013, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Immunity protein BC_0921;
GN   OrderedLocusNames=BC_0921;
OS   Bacillus cereus (strain ATCC 14579 / DSM 31 / CCUG 7414 / JCM 2152 / NBRC
OS   15305 / NCIMB 9373 / NCTC 2599 / NRRL B-3711).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=226900;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 14579 / DSM 31 / CCUG 7414 / JCM 2152 / NBRC 15305 / NCIMB 9373
RC   / NCTC 2599 / NRRL B-3711;
RX   PubMed=12721630; DOI=10.1038/nature01582;
RA   Ivanova N., Sorokin A., Anderson I., Galleron N., Candelon B., Kapatral V.,
RA   Bhattacharyya A., Reznik G., Mikhailova N., Lapidus A., Chu L., Mazur M.,
RA   Goltsman E., Larsen N., D'Souza M., Walunas T., Grechkin Y., Pusch G.,
RA   Haselkorn R., Fonstein M., Ehrlich S.D., Overbeek R., Kyrpides N.C.;
RT   "Genome sequence of Bacillus cereus and comparative analysis with Bacillus
RT   anthracis.";
RL   Nature 423:87-91(2003).
RN   [2]
RP   FUNCTION AS AN IMMUNITY PROTEIN, AND EXPRESSION IN E.COLI.
RC   STRAIN=ATCC 14579 / DSM 31 / CCUG 7414 / JCM 2152 / NBRC 15305 / NCIMB 9373
RC   / NCTC 2599 / NRRL B-3711;
RX   PubMed=22200572; DOI=10.1016/j.febslet.2011.12.020;
RA   Holberger L.E., Garza-Sanchez F., Lamoureux J., Low D.A., Hayes C.S.;
RT   "A novel family of toxin/antitoxin proteins in Bacillus species.";
RL   FEBS Lett. 586:132-136(2012).
RN   [3]
RP   FUNCTION.
RC   STRAIN=ATCC 14579 / DSM 31 / CCUG 7414 / JCM 2152 / NBRC 15305 / NCIMB 9373
RC   / NCTC 2599 / NRRL B-3711;
RX   PubMed=29923643; DOI=10.1111/mmi.14007;
RA   Michalska K., Quan Nhan D., Willett J.L.E., Stols L.M., Eschenfeldt W.H.,
RA   Jones A.M., Nguyen J.Y., Koskiniemi S., Low D.A., Goulding C.W.,
RA   Joachimiak A., Hayes C.S.;
RT   "Functional plasticity of antibacterial EndoU toxins.";
RL   Mol. Microbiol. 109:509-527(2018).
CC   -!- FUNCTION: Immunity component of an LXG toxin-immunity module.
CC       Neutralizes the RNase activity of cognate toxin BC_0920. Probably does
CC       not have immunity protein activity on other toxins with the LXG domain.
CC       {ECO:0000269|PubMed:22200572, ECO:0000269|PubMed:29923643}.
CC   -!- SUBUNIT: Probably interacts with cognate toxin BC_0920 but not with
CC       other non-cognate toxins. The interaction inhibits the toxic activity
CC       of BC_0920 (Probable). {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
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DR   EMBL; AE016877; AAP07908.1; -; Genomic_DNA.
DR   RefSeq; NP_830707.1; NC_004722.1.
DR   RefSeq; WP_000877046.1; NZ_CP034551.1.
DR   AlphaFoldDB; Q81H98; -.
DR   SMR; Q81H98; -.
DR   EnsemblBacteria; AAP07908; AAP07908; BC_0921.
DR   KEGG; bce:BC0921; -.
DR   PATRIC; fig|226900.8.peg.869; -.
DR   HOGENOM; CLU_166653_0_0_9; -.
DR   OMA; WFINGIM; -.
DR   Proteomes; UP000001417; Chromosome.
PE   1: Evidence at protein level;
KW   Cytoplasm; Reference proteome.
FT   CHAIN           1..117
FT                   /note="Immunity protein BC_0921"
FT                   /id="PRO_0000424069"
SQ   SEQUENCE   117 AA;  13464 MW;  02703C0AEB0B49F2 CRC64;
     MKYPYSFEVL TNGKLVMRLP QEIKLMETFL GVEVSAFGDW ILEEIHSVLN GKENYVVVNG
     NICGLEIRKD TTTVLDNLAE DGKGDFCEIE TIELVDLIHI WQDKQKEFKK GKNKELK