ID   ATOX1_DICDI             Reviewed;          67 AA.
AC   Q54PZ2;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 2.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Copper transport protein ATOX1 homolog;
GN   Name=atox1; ORFNames=DDB_G0284221;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Could bind and deliver cytosolic copper to the copper ATPase
CC       proteins. May be important in cellular antioxidant defense (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ATX1 family. {ECO:0000305}.
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DR   EMBL; AAFI02000064; EAL65299.2; -; Genomic_DNA.
DR   RefSeq; XP_638653.2; XM_633561.2.
DR   AlphaFoldDB; Q54PZ2; -.
DR   SMR; Q54PZ2; -.
DR   STRING; 44689.DDB0266724; -.
DR   PaxDb; Q54PZ2; -.
DR   EnsemblProtists; EAL65299; EAL65299; DDB_G0284221.
DR   GeneID; 8624483; -.
DR   KEGG; ddi:DDB_G0284221; -.
DR   dictyBase; DDB_G0284221; atox1.
DR   eggNOG; ENOG502SBXZ; Eukaryota.
DR   HOGENOM; CLU_134973_3_1_1; -.
DR   InParanoid; Q54PZ2; -.
DR   OMA; MAETHTY; -.
DR   PhylomeDB; Q54PZ2; -.
DR   PRO; PR:Q54PZ2; -.
DR   Proteomes; UP000002195; Chromosome 4.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0016531; F:copper chaperone activity; ISS:dictyBase.
DR   GO; GO:0032767; F:copper-dependent protein binding; ISS:dictyBase.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006825; P:copper ion transport; ISS:dictyBase.
DR   CDD; cd00371; HMA; 1.
DR   InterPro; IPR006121; HMA_dom.
DR   InterPro; IPR036163; HMA_dom_sf.
DR   Pfam; PF00403; HMA; 1.
DR   SUPFAM; SSF55008; SSF55008; 1.
DR   PROSITE; PS50846; HMA_2; 1.
PE   3: Inferred from homology;
KW   Chaperone; Copper; Copper transport; Ion transport; Metal-binding;
KW   Reference proteome; Transport.
FT   CHAIN           1..67
FT                   /note="Copper transport protein ATOX1 homolog"
FT                   /id="PRO_0000331119"
FT   DOMAIN          1..64
FT                   /note="HMA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00280"
FT   BINDING         11
FT                   /ligand="Cu cation"
FT                   /ligand_id="ChEBI:CHEBI:23378"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00280"
FT   BINDING         14
FT                   /ligand="Cu cation"
FT                   /ligand_id="ChEBI:CHEBI:23378"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00280"
SQ   SEQUENCE   67 AA;  7206 MW;  1FC3E27CB2B399F7 CRC64;
     MTYSFFVDMT CGGCSKAVNA ILSKIDGVSN IQIDLENKKV SCESSKMGAD ELLKNIQKTG
     KKCSIIA