ATO_DROME
ID ATO_DROME Reviewed; 312 AA.
AC P48987; A0AQ36; A0AQ37; A0AQ43; Q9VHU0;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 21-FEB-2001, sequence version 2.
DT 03-AUG-2022, entry version 170.
DE RecName: Full=Protein atonal;
GN Name=ato; ORFNames=CG7508;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC STRAIN=Oregon-R;
RX PubMed=8324823; DOI=10.1016/0092-8674(93)90358-w;
RA Jarman A.P., Grau Y., Jan L.Y., Jan Y.N.;
RT "Atonal is a proneural gene that directs chordotonal organ formation in the
RT Drosophila peripheral nervous system.";
RL Cell 73:1307-1321(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ZBMEL131, ZBMEL145, ZBMEL157, ZBMEL186, ZBMEL191, ZBMEL229,
RC ZBMEL377, ZBMEL384, ZBMEL398, ZBMEL82, ZBMEL84, and ZBMEL95;
RX PubMed=16951084; DOI=10.1534/genetics.106.058008;
RA Proeschel M., Zhang Z., Parsch J.;
RT "Widespread adaptive evolution of Drosophila genes with sex-biased
RT expression.";
RL Genetics 174:893-900(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [5]
RP FUNCTION.
RX PubMed=8196767; DOI=10.1038/369398a0;
RA Jarman A.P., Grell E.H., Ackerman L., Jan L.Y., Jan Y.N.;
RT "Atonal is the proneural gene for Drosophila photoreceptors.";
RL Nature 369:398-400(1994).
CC -!- FUNCTION: Developmental protein involved in neurogenesis. Required for
CC the formation of chordotonal organs and photoreceptors. Seems to bind
CC to E boxes. Specifically required for the photoreceptor R8 selection.
CC {ECO:0000269|PubMed:8196767, ECO:0000269|PubMed:8324823}.
CC -!- SUBUNIT: Efficient DNA binding requires dimerization with another bHLH
CC protein. Forms a heterodimer with Daughterless.
CC -!- INTERACTION:
CC P48987; Q91YV0: Tcf4; Xeno; NbExp=2; IntAct=EBI-1639335, EBI-15658970;
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- TISSUE SPECIFICITY: Proneural clusters and sense organ precursors of
CC the chordotonal organs, optic furrow of the eye-antennal disk and
CC developing brain lobe. {ECO:0000269|PubMed:8324823}.
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DR EMBL; L36646; AAA21879.1; -; mRNA.
DR EMBL; AM294774; CAL26760.1; -; Genomic_DNA.
DR EMBL; AM294775; CAL26761.1; -; Genomic_DNA.
DR EMBL; AM294776; CAL26762.1; -; Genomic_DNA.
DR EMBL; AM294777; CAL26763.1; -; Genomic_DNA.
DR EMBL; AM294778; CAL26764.1; -; Genomic_DNA.
DR EMBL; AM294779; CAL26765.1; -; Genomic_DNA.
DR EMBL; AM294780; CAL26766.1; -; Genomic_DNA.
DR EMBL; AM294781; CAL26767.1; -; Genomic_DNA.
DR EMBL; AM294782; CAL26768.1; -; Genomic_DNA.
DR EMBL; AM294783; CAL26769.1; -; Genomic_DNA.
DR EMBL; AM294784; CAL26770.1; -; Genomic_DNA.
DR EMBL; AM294785; CAL26771.1; -; Genomic_DNA.
DR EMBL; AE014297; AAF54209.1; -; Genomic_DNA.
DR PIR; A40708; A40708.
DR RefSeq; NP_731223.1; NM_169213.2.
DR AlphaFoldDB; P48987; -.
DR SMR; P48987; -.
DR BioGRID; 66156; 34.
DR DIP; DIP-151N; -.
DR IntAct; P48987; 8.
DR STRING; 7227.FBpp0081318; -.
DR PaxDb; P48987; -.
DR PRIDE; P48987; -.
DR EnsemblMetazoa; FBtr0081828; FBpp0081318; FBgn0010433.
DR GeneID; 40975; -.
DR KEGG; dme:Dmel_CG7508; -.
DR UCSC; CG7508-RA; d. melanogaster.
DR CTD; 40975; -.
DR FlyBase; FBgn0010433; ato.
DR VEuPathDB; VectorBase:FBgn0010433; -.
DR eggNOG; KOG4395; Eukaryota.
DR GeneTree; ENSGT00940000168200; -.
DR HOGENOM; CLU_980979_0_0_1; -.
DR InParanoid; P48987; -.
DR OMA; EIYRYYY; -.
DR OrthoDB; 1626607at2759; -.
DR PhylomeDB; P48987; -.
DR SignaLink; P48987; -.
DR BioGRID-ORCS; 40975; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 40975; -.
DR PRO; PR:P48987; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0010433; Expressed in adult sense organ (Drosophila) and 33 other tissues.
DR ExpressionAtlas; P48987; baseline and differential.
DR Genevisible; P48987; DM.
DR GO; GO:0005634; C:nucleus; IDA:FlyBase.
DR GO; GO:0046982; F:protein heterodimerization activity; IPI:FlyBase.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0048801; P:antennal joint morphogenesis; IMP:FlyBase.
DR GO; GO:0048800; P:antennal morphogenesis; IMP:FlyBase.
DR GO; GO:0001746; P:Bolwig's organ morphogenesis; IEP:FlyBase.
DR GO; GO:0007420; P:brain development; IMP:FlyBase.
DR GO; GO:0045165; P:cell fate commitment; IMP:FlyBase.
DR GO; GO:0007455; P:eye-antennal disc morphogenesis; IMP:FlyBase.
DR GO; GO:0001748; P:insect visual primordium development; IMP:FlyBase.
DR GO; GO:0045433; P:male courtship behavior, veined wing generated song production; IMP:FlyBase.
DR GO; GO:0007399; P:nervous system development; TAS:FlyBase.
DR GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR GO; GO:0008038; P:neuron recognition; IMP:FlyBase.
DR GO; GO:0007438; P:oenocyte development; IMP:FlyBase.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEP:FlyBase.
DR GO; GO:0010608; P:post-transcriptional regulation of gene expression; IMP:FlyBase.
DR GO; GO:0007460; P:R8 cell fate commitment; IMP:FlyBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0007423; P:sensory organ development; IMP:FlyBase.
DR GO; GO:0016360; P:sensory organ precursor cell fate determination; IDA:FlyBase.
DR GO; GO:0007605; P:sensory perception of sound; IMP:FlyBase.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 1: Evidence at protein level;
KW Developmental protein; Differentiation; DNA-binding; Neurogenesis; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..312
FT /note="Protein atonal"
FT /id="PRO_0000127142"
FT DOMAIN 255..307
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 136..174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 220..248
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 154..174
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 104
FT /note="N -> K (in strain: ZBMEL191)"
FT VARIANT 146
FT /note="A -> T (in strain: ZBMEL191)"
FT VARIANT 149
FT /note="G -> A (in strain: Oregon-R, ZBMEL84, ZBMEL95,
FT ZBMEL131, ZBMEL157, ZBMEL186, ZBMEL191 and ZBMEL229)"
SQ SEQUENCE 312 AA; 34116 MW; 069479287438F456 CRC64;
MSSSEIYRYY YKTSEDLQGF KTAAAEPYFN PMAAYNPGVT HYQFNGNTLA SSSNYLSANG
FISFEQASSD GWISSSPASH RSESPEYVDL NTMYNGGCNN MAQNQQYGMI MEQSVVSTAP
AIPVASPPAV EVMGSSNVGT CKTIPASAGP KPKRSYTKKN QPSTTATSTP TAAAESSASV
NLYTEEFQNF DFDNSALFDD SVEDDEDLML FSGGEDFDGN DGSFDLADGE NQDAAAGGSG
KKRRGKQITP VVKRKRRLAA NARERRRMQN LNQAFDRLRQ YLPCLGNDRQ LSKHETLQMA
QTYISALGDL LR
