PSTC2_MYCTO
ID PSTC2_MYCTO Reviewed; 324 AA.
AC P9WG04; L0T849; O86344; P0A630; Q50797;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 25-MAY-2022, entry version 36.
DE RecName: Full=Phosphate transport system permease protein PstC 2;
GN Name=pstC2; OrderedLocusNames=MT0956;
OS Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83331;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CDC 1551 / Oshkosh;
RX PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT laboratory strains.";
RL J. Bacteriol. 184:5479-5490(2002).
CC -!- FUNCTION: Part of the binding-protein-dependent transport system for
CC phosphate; probably responsible for the translocation of the substrate
CC across the membrane. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
CC -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC permease family. CysTW subfamily. {ECO:0000305}.
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DR EMBL; AE000516; AAK45203.1; -; Genomic_DNA.
DR PIR; A70584; A70584.
DR RefSeq; WP_003404779.1; NZ_KK341227.1.
DR AlphaFoldDB; P9WG04; -.
DR EnsemblBacteria; AAK45203; AAK45203; MT0956.
DR GeneID; 45424895; -.
DR KEGG; mtc:MT0956; -.
DR PATRIC; fig|83331.31.peg.1026; -.
DR HOGENOM; CLU_033621_1_3_11; -.
DR Proteomes; UP000001020; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005315; F:inorganic phosphate transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006817; P:phosphate ion transport; IEA:UniProtKB-KW.
DR CDD; cd06261; TM_PBP2; 1.
DR Gene3D; 1.10.3720.10; -; 1.
DR InterPro; IPR000515; MetI-like.
DR InterPro; IPR035906; MetI-like_sf.
DR InterPro; IPR011864; Phosphate_PstC.
DR Pfam; PF00528; BPD_transp_1; 1.
DR SUPFAM; SSF161098; SSF161098; 1.
DR TIGRFAMs; TIGR02138; phosphate_pstC; 1.
DR PROSITE; PS50928; ABC_TM1; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Phosphate transport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..324
FT /note="Phosphate transport system permease protein PstC 2"
FT /id="PRO_0000428446"
FT TRANSMEM 30..50
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 90..110
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 125..145
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 174..194
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 237..257
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 290..310
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 85..314
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
SQ SEQUENCE 324 AA; 34262 MW; 0C54657C8A3CEAC5 CRC64;
MVTEPLTKPA LVAVDMRPAR RGERLFKLAA SAAGSTIVIA ILLIAIFLLV RAVPSLRANH
ANFFTSTQFD TSDDEQLAFG VRDLFMVTAL SSITALVLAV PVAVGIAVFL THYAPRRLSR
PFGAMVDLLA AVPSIIFGLW GIFVLAPKLE PIARFLNRNL GWLFLFKQGN VSLAGGGTIF
TAGIVLSVMI LPIVTSISRE VFRQTPLIQI EAALALGATK WEVVRMTVLP YGRSGVVAAS
MLGLGRALGE TVAVLVILRS AARPGTWSLF DGGYTFASKI ASAASEFSEP LPTGAYISAG
FALFVLTFLV NAAARAIAGG KVNG