PSTC_MYCLE
ID PSTC_MYCLE Reviewed; 319 AA.
AC Q50098;
DT 23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 25-MAY-2022, entry version 117.
DE RecName: Full=Phosphate transport system permease protein PstC;
GN Name=pstC; Synonyms=phoW1, pstC2; OrderedLocusNames=ML2094;
OS Mycobacterium leprae (strain TN).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=272631;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Smith D.R., Robison K.;
RL Submitted (SEP-1994) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TN;
RX PubMed=11234002; DOI=10.1038/35059006;
RA Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA Barrell B.G.;
RT "Massive gene decay in the leprosy bacillus.";
RL Nature 409:1007-1011(2001).
CC -!- FUNCTION: Part of a binding-protein-dependent transport system for
CC phosphate; probably responsible for the translocation of the substrate
CC across the membrane. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC permease family. CysTW subfamily. {ECO:0000305}.
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DR EMBL; U15184; AAA63077.1; -; Genomic_DNA.
DR EMBL; AL583924; CAC31049.1; -; Genomic_DNA.
DR PIR; A87171; A87171.
DR RefSeq; NP_302394.1; NC_002677.1.
DR RefSeq; WP_010908714.1; NC_002677.1.
DR AlphaFoldDB; Q50098; -.
DR STRING; 272631.ML2094; -.
DR EnsemblBacteria; CAC31049; CAC31049; CAC31049.
DR KEGG; mle:ML2094; -.
DR PATRIC; fig|272631.5.peg.3940; -.
DR Leproma; ML2094; -.
DR eggNOG; COG0573; Bacteria.
DR HOGENOM; CLU_033621_1_3_11; -.
DR OMA; GNIAIEM; -.
DR Proteomes; UP000000806; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005315; F:inorganic phosphate transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006817; P:phosphate ion transport; IEA:UniProtKB-KW.
DR CDD; cd06261; TM_PBP2; 1.
DR Gene3D; 1.10.3720.10; -; 1.
DR InterPro; IPR000515; MetI-like.
DR InterPro; IPR035906; MetI-like_sf.
DR InterPro; IPR011864; Phosphate_PstC.
DR Pfam; PF00528; BPD_transp_1; 1.
DR SUPFAM; SSF161098; SSF161098; 1.
DR TIGRFAMs; TIGR02138; phosphate_pstC; 1.
DR PROSITE; PS50928; ABC_TM1; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Phosphate transport; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..319
FT /note="Phosphate transport system permease protein PstC"
FT /id="PRO_0000060217"
FT TRANSMEM 25..45
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 84..104
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 120..140
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 141..161
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 169..189
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 233..253
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 289..309
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 80..309
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
SQ SEQUENCE 319 AA; 33505 MW; 63FF703895045B40 CRC64;
MIKPTPAAVG SYVTRRCDRL FKSAAAAAGS TVVAAILLIA IFLLLRAVPS LRANHANFFT
SAKFDTTGDK NLAFGIRDLF MVTVLSSICA LVLAVPVAIG IAVFLTQYVP ARLSRLFSAM
VDLLAAVPSI IFGLWGVFVL APKLQPIAVF LNHNLGWLFL FKQGNVSLAG GGTIFTSGIV
LAVMILPIVT SVSREVFRHT PLIQIEAAQA LGATKWEVVQ MTVLPFGRSG VAAAAMLGLG
RALGETLAVL IILRSAARSG NWSLFDGGYT FASKIASAAS EFSQPLPTGA YIAAGFALFF
LTFVVNAVAR AISGGRVNG
