ATP10_YEAST
ID ATP10_YEAST Reviewed; 279 AA.
AC P18496; D6VZ28; Q06020;
DT 01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT 16-MAY-2003, sequence version 2.
DT 03-AUG-2022, entry version 159.
DE RecName: Full=Mitochondrial ATPase complex subunit ATP10;
GN Name=ATP10; OrderedLocusNames=YLR393W; ORFNames=L8084.8;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2141026; DOI=10.1016/s0021-9258(19)38763-0;
RA Ackerman S.H., Tzagoloff A.;
RT "ATP 10, a yeast nuclear gene required for the assembly of the
RT mitochondrial F1-F0 complex.";
RL J. Biol. Chem. 265:9952-9959(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169871;
RA Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W.,
RA Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A.,
RA Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K.,
RA Heuss-Neitzel D., Hilbert H., Hilger F., Kleine K., Koetter P., Louis E.J.,
RA Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S.,
RA Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D.,
RA Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M.,
RA Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P.,
RA Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M.,
RA Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K.,
RA Zollner A., Hani J., Hoheisel J.D.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.";
RL Nature 387:87-90(1997).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [5]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
CC -!- FUNCTION: Essential for the assembly of the mitochondrial F1-F0
CC complex.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane.
CC -!- MISCELLANEOUS: Mutations in ATP10 induce a loss of rutamycin
CC sensitivity of mitochondrial ATPase.
CC -!- MISCELLANEOUS: Present with 1890 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the ATP10 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB05633.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; J05463; AAB05633.1; ALT_INIT; Genomic_DNA.
DR EMBL; U19729; AAB82347.1; -; Genomic_DNA.
DR EMBL; AY558229; AAS56555.1; -; Genomic_DNA.
DR EMBL; BK006945; DAA09694.1; -; Genomic_DNA.
DR PIR; S55949; S55949.
DR RefSeq; NP_013497.1; NM_001182281.1.
DR AlphaFoldDB; P18496; -.
DR BioGRID; 31652; 381.
DR DIP; DIP-4641N; -.
DR IntAct; P18496; 1.
DR STRING; 4932.YLR393W; -.
DR MaxQB; P18496; -.
DR PaxDb; P18496; -.
DR PRIDE; P18496; -.
DR EnsemblFungi; YLR393W_mRNA; YLR393W; YLR393W.
DR GeneID; 851109; -.
DR KEGG; sce:YLR393W; -.
DR SGD; S000004385; ATP10.
DR VEuPathDB; FungiDB:YLR393W; -.
DR eggNOG; KOG4614; Eukaryota.
DR HOGENOM; CLU_047290_2_0_1; -.
DR InParanoid; P18496; -.
DR OMA; CLLCQWR; -.
DR BioCyc; YEAST:G3O-32458-MON; -.
DR PRO; PR:P18496; -.
DR Proteomes; UP000002311; Chromosome XII.
DR RNAct; P18496; protein.
DR GO; GO:0005737; C:cytoplasm; HDA:SGD.
DR GO; GO:0032592; C:integral component of mitochondrial membrane; IDA:SGD.
DR GO; GO:0005743; C:mitochondrial inner membrane; IPI:SGD.
DR GO; GO:0005739; C:mitochondrion; HDA:SGD.
DR GO; GO:0051082; F:unfolded protein binding; IPI:SGD.
DR GO; GO:0033615; P:mitochondrial proton-transporting ATP synthase complex assembly; IMP:SGD.
DR InterPro; IPR007849; ATP10.
DR PANTHER; PTHR28106; PTHR28106; 1.
DR Pfam; PF05176; ATP-synt_10; 1.
PE 1: Evidence at protein level;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome.
FT CHAIN 1..279
FT /note="Mitochondrial ATPase complex subunit ATP10"
FT /id="PRO_0000071727"
FT CONFLICT 224
FT /note="C -> Y (in Ref. 2; AAB05633)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 279 AA; 32094 MW; 404581AFFB820029 CRC64;
MQGTFKRFYH PTLTRMSFLD KFLKPMMATA SPKEYQIKQL VKPIGLTQAP RKSTKYSQGN
SLRDMFDSEK TNHRVKELAV EFSKSGLYDV QVFQKTKGKL FIAPVSYWKE DKALFFPHLI
GTAMDGTKQQ NIEDMLRGKT SIVRLFSTAS GDKLSSSYFQ GIVDDNKKTD YLTEADARLS
LNDSNVQIIE VNLVENAVKS ALVKTLARWA NRVPSWRQPF YFECSRGQWP FSVREELFCN
NVFSGYVFLV DQQLKIRWAA CGEATPSEKE ALWKFAKRL
