ID   PSTN_POLPI              Reviewed;          21 AA.
AC   C0HKQ9;
DT   30-AUG-2017, integrated into UniProtKB/Swiss-Prot.
DT   30-AUG-2017, sequence version 1.
DT   25-MAY-2022, entry version 6.
DE   RecName: Full=Paulistine {ECO:0000303|PubMed:24007897};
OS   Polybia paulista (Neotropical social wasp) (Swarm-founding polistine wasp).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Vespoidea;
OC   Vespidae; Polistinae; Epiponini; Polybia.
OX   NCBI_TaxID=291283 {ECO:0000303|PubMed:24007897};
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, FUNCTION, MASS SPECTROMETRY, DISULFIDE BOND, AND
RP   AMIDATION AT THR-21.
RC   TISSUE=Venom {ECO:0000303|PubMed:24007897};
RX   PubMed=24007897; DOI=10.1016/j.bbagen.2013.08.024;
RA   Gomes P.C., de Souza B.M., Dias N.B., Brigatte P., Mourelle D.,
RA   Arcuri H.A., dos Santos Cabrera M.P., Stabeli R.G., Neto J.R., Palma M.S.;
RT   "Structure-function relationships of the peptide Paulistine: a novel toxin
RT   from the venom of the social wasp Polybia paulista.";
RL   Biochim. Biophys. Acta 1840:170-183(2014).
RN   [2] {ECO:0000305}
RP   FUNCTION.
RX   PubMed=26938560; DOI=10.3390/toxins8030061;
RA   Arcuri H.A., Gomes P.C., de Souza B.M., Dias N.B., Brigatte P.,
RA   Stabeli R.G., Palma M.S.;
RT   "Paulistine--The Functional Duality of a Wasp Venom Peptide Toxin.";
RL   Toxins 8:61-61(2016).
CC   -!- FUNCTION: Induces transient hyperalgesia and paw edema in mice
CC       (PubMed:24007897, PubMed:26938560). Probably exerts its effects via
CC       different pathways in an oxidation state-dependent way
CC       (PubMed:26938560). {ECO:0000269|PubMed:24007897,
CC       ECO:0000269|PubMed:26938560}.
CC   -!- PTM: Occurs in oxidized and reduced states which are thought to adopt a
CC       compact globular and linear structure, respectively.
CC       {ECO:0000269|PubMed:24007897}.
CC   -!- MASS SPECTROMETRY: Mass=2359.32; Method=Electrospray; Note=Oxidized.;
CC       Evidence={ECO:0000269|PubMed:24007897};
CC   -!- MASS SPECTROMETRY: Mass=2361.32; Method=Electrospray; Note=Reduced.;
CC       Evidence={ECO:0000269|PubMed:24007897};
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DR   AlphaFoldDB; C0HKQ9; -.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Disulfide bond; Toxin.
FT   PEPTIDE         1..21
FT                   /note="Paulistine"
FT                   /evidence="ECO:0000269|PubMed:24007897"
FT                   /id="PRO_0000441219"
FT   MOD_RES         21
FT                   /note="Threonine amide"
FT                   /evidence="ECO:0000269|PubMed:24007897"
FT   DISULFID        7..14
FT                   /note="Partial"
FT                   /evidence="ECO:0000269|PubMed:24007897"
SQ   SEQUENCE   21 AA;  2363 MW;  DC474DBBF1B05DAB CRC64;
     SIKDKICKII QAQCGKKLPF T