PSTOM_PYRHO
ID PSTOM_PYRHO Reviewed; 266 AA.
AC O59180;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 25-MAY-2022, entry version 112.
DE RecName: Full=Stomatin homolog PH1511;
DE AltName: Full=Prokaryotic stomatin;
DE Short=P-stomatin;
GN OrderedLocusNames=PH1511;
OS Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC
OS 100139 / OT-3).
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Pyrococcus.
OX NCBI_TaxID=70601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3;
RX PubMed=9679194; DOI=10.1093/dnares/5.2.55;
RA Kawarabayasi Y., Sawada M., Horikawa H., Haikawa Y., Hino Y., Yamamoto S.,
RA Sekine M., Baba S., Kosugi H., Hosoyama A., Nagai Y., Sakai M., Ogura K.,
RA Otsuka R., Nakazawa H., Takamiya M., Ohfuku Y., Funahashi T., Tanaka T.,
RA Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Yoshizawa T.,
RA Nakamura Y., Robb F.T., Horikoshi K., Masuchi Y., Shizuya H., Kikuchi H.;
RT "Complete sequence and gene organization of the genome of a hyper-
RT thermophilic archaebacterium, Pyrococcus horikoshii OT3.";
RL DNA Res. 5:55-76(1998).
RN [2]
RP X-RAY CRYSTALLOGRAPHY (3.20 ANGSTROMS) OF 56-234, SUBUNIT, AND COILED COIL.
RX PubMed=18182167; DOI=10.1016/j.jmb.2007.12.024;
RA Yokoyama H., Fujii S., Matsui I.;
RT "Crystal structure of a core domain of stomatin from Pyrococcus horikoshii
RT illustrates a novel trimeric and coiled-coil fold.";
RL J. Mol. Biol. 376:868-878(2008).
RN [3]
RP X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS) OF 234-243 IN COMPLEX WITH PH1510.
RX PubMed=22475127; DOI=10.1021/bi300098k;
RA Yokoyama H., Takizawa N., Kobayashi D., Matsui I., Fujii S.;
RT "Crystal structure of a membrane stomatin-specific protease in complex with
RT a substrate peptide.";
RL Biochemistry 51:3872-3880(2012).
RN [4]
RP X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 234-243 IN COMPLEX WITH PH1510.
RX PubMed=24121343; DOI=10.1107/s0909049513021328;
RA Yokoyama H., Kobayashi D., Takizawa N., Fujii S., Matsui I.;
RT "Structural and biochemical analysis of a thermostable membrane-bound
RT stomatin-specific protease.";
RL J. Synchrotron Radiat. 20:933-937(2013).
CC -!- SUBUNIT: Homotrimer. Interacts with PH1510 and is cleaved by PH1510.
CC {ECO:0000269|PubMed:18182167, ECO:0000269|PubMed:22475127,
CC ECO:0000269|PubMed:24121343}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the band 7/mec-2 family. {ECO:0000305}.
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DR EMBL; BA000001; BAA30619.1; -; Genomic_DNA.
DR PIR; C71027; C71027.
DR RefSeq; WP_010885588.1; NC_000961.1.
DR PDB; 3BK6; X-ray; 3.20 A; A/B/C=56-234.
DR PDB; 3VIV; X-ray; 2.25 A; C=234-243.
DR PDB; 3WG5; X-ray; 2.40 A; C=234-243.
DR PDBsum; 3BK6; -.
DR PDBsum; 3VIV; -.
DR PDBsum; 3WG5; -.
DR AlphaFoldDB; O59180; -.
DR SMR; O59180; -.
DR STRING; 70601.3257936; -.
DR TCDB; 8.A.21.2.1; the stomatin/podocin/band 7/nephrosis,2/spfh (stomatin) family.
DR EnsemblBacteria; BAA30619; BAA30619; BAA30619.
DR GeneID; 1443827; -.
DR KEGG; pho:PH1511; -.
DR eggNOG; arCOG01915; Archaea.
DR OMA; NAVLYFR; -.
DR OrthoDB; 49614at2157; -.
DR EvolutionaryTrace; O59180; -.
DR Proteomes; UP000000752; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR Gene3D; 3.30.479.30; -; 1.
DR InterPro; IPR043202; Band-7_stomatin-like.
DR InterPro; IPR001107; Band_7.
DR InterPro; IPR036013; Band_7/SPFH_dom_sf.
DR InterPro; IPR018080; Band_7/stomatin-like_CS.
DR InterPro; IPR001972; Stomatin_HflK_HflKC_fam.
DR PANTHER; PTHR10264; PTHR10264; 1.
DR Pfam; PF01145; Band_7; 1.
DR PRINTS; PR00721; STOMATIN.
DR SMART; SM00244; PHB; 1.
DR SUPFAM; SSF117892; SSF117892; 1.
DR PROSITE; PS01270; BAND_7; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Coiled coil; Membrane; Transmembrane; Transmembrane helix.
FT CHAIN 1..266
FT /note="Stomatin homolog PH1511"
FT /id="PRO_0000094067"
FT TRANSMEM 7..27
FT /note="Helical"
FT /evidence="ECO:0000255"
FT COILED 125..152
FT /evidence="ECO:0000255"
FT COILED 178..213
FT /evidence="ECO:0000269|PubMed:18182167"
FT STRAND 57..59
FT /evidence="ECO:0007829|PDB:3BK6"
FT STRAND 68..78
FT /evidence="ECO:0007829|PDB:3BK6"
FT STRAND 84..96
FT /evidence="ECO:0007829|PDB:3BK6"
FT HELIX 98..103
FT /evidence="ECO:0007829|PDB:3BK6"
FT STRAND 104..106
FT /evidence="ECO:0007829|PDB:3BK6"
FT HELIX 108..125
FT /evidence="ECO:0007829|PDB:3BK6"
FT HELIX 129..134
FT /evidence="ECO:0007829|PDB:3BK6"
FT HELIX 136..150
FT /evidence="ECO:0007829|PDB:3BK6"
FT HELIX 152..154
FT /evidence="ECO:0007829|PDB:3BK6"
FT STRAND 156..169
FT /evidence="ECO:0007829|PDB:3BK6"
FT HELIX 172..212
FT /evidence="ECO:0007829|PDB:3BK6"
FT HELIX 216..221
FT /evidence="ECO:0007829|PDB:3BK6"
SQ SEQUENCE 266 AA; 29999 MW; 21D06F199C31021F CRC64;
MMFATNFFVT SIILLFILIF LASAIKIVKE YERAVIFRLG RVVGARGPGL FFIIPIFEKA
VIVDLRTQVL DVPVQETITK DNVPVRVNAV VYFRVVDPVK AVTQVKNYIM ATSQISQTTL
RSVIGQAHLD ELLSERDKLN MQLQRIIDEA TDPWGIKVTA VEIKDVELPA GMQKAMARQA
EAERERRARI TLAEAERQAA EKLREAAEII SEHPMALQLR TLQTISDVAG DKSNVIVLML
PMEMLKLFKS LSDAAEAYMK KKEEEK
