PSV_DICDI
ID PSV_DICDI Reviewed; 514 AA.
AC P08798; P32258; Q550G6; Q86AZ4;
DT 01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 3.
DT 25-MAY-2022, entry version 90.
DE RecName: Full=Prespore vesicle protein;
DE Short=PSV;
DE Flags: Precursor;
GN Name=psvA; Synonyms=EB4; ORFNames=DDB_G0276869;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=AX2;
RX PubMed=1840491; DOI=10.1016/0006-291x(91)91273-f;
RA Hildebrandt M., Nellen W.;
RT "Library-independent cloning of genomic fragments adjacent to vector
RT integration sites: isolation of the EB4-PSV gene from a Dictyostelium gene
RT disruption transformant.";
RL Biochem. Biophys. Res. Commun. 181:884-888(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=AX2;
RX PubMed=2049876; DOI=10.1002/dvg.1020120125;
RA Hildebrandt M., Saur U., Nellen W.;
RT "Structure, expression, and inactivation by gene disruption of the
RT Dictyostelium discoideum prespore gene EB4.";
RL Dev. Genet. 12:163-169(1991).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 252-284.
RX PubMed=3897836; DOI=10.1128/mcb.5.6.1465-1472.1985;
RA Barklis E., Pontius B., Barfield K., Lodish H.F.;
RT "Structure of the promoter of the Dictyostelium discoideum prespore EB4
RT gene.";
RL Mol. Cell. Biol. 5:1465-1472(1985).
CC -!- DEVELOPMENTAL STAGE: Accumulates only in prespore cells.
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DR EMBL; X57149; CAA40438.1; -; Genomic_DNA.
DR EMBL; AAFI02000019; EAL68936.1; -; Genomic_DNA.
DR EMBL; M11028; AAA33204.1; ALT_SEQ; Genomic_DNA.
DR PIR; S28358; S28358.
DR RefSeq; XP_642966.1; XM_637874.1.
DR AlphaFoldDB; P08798; -.
DR STRING; 44689.DDB0185116; -.
DR PaxDb; P08798; -.
DR EnsemblProtists; EAL68936; EAL68936; DDB_G0276869.
DR GeneID; 8620836; -.
DR KEGG; ddi:DDB_G0276869; -.
DR dictyBase; DDB_G0276869; psvA.
DR eggNOG; ENOG502RSQ2; Eukaryota.
DR HOGENOM; CLU_530453_0_0_1; -.
DR OMA; AKPVQHN; -.
DR PRO; PR:P08798; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0031160; C:spore wall; IDA:dictyBase.
DR GO; GO:0012506; C:vesicle membrane; IDA:dictyBase.
DR GO; GO:0030248; F:cellulose binding; IDA:dictyBase.
DR GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IC:dictyBase.
DR InterPro; IPR003645; Fol_N.
DR SMART; SM00274; FOLN; 2.
PE 2: Evidence at transcript level;
KW Developmental protein; Differentiation; Reference proteome; Repeat; Signal;
KW Sporulation.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..514
FT /note="Prespore vesicle protein"
FT /id="PRO_0000032669"
FT DOMAIN 40..62
FT /note="Follistatin-like 1"
FT DOMAIN 240..262
FT /note="Follistatin-like 2"
FT REGION 285..514
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 285..300
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 308..365
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 476..514
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 409
FT /note="Missing (in Ref. 1; CAA40438)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 514 AA; 55447 MW; 45D5BD3FCE77E004 CRC64;
MRLYLLSLIL VFYASVSSAS LDSVNFGRGG GWGSGNQGVL CGTHYCPPGS TCESKHGHYI
CRPGGLITAP SGGDSGGIWT GGDKHKKDCG GTGCCKEGQY CTKLDGKEQC VYYPDDKGPQ
CGGSFCREGE ICVLEHGVLG CLENPVEDSK ANCGLFHCNY NEYCIMVNGY LQCLFSNGTA
PFACGLQTCV PPQLCVKVEN CQQCVSPPRP DNNCGDKYCD DEHQCVRKGL GYECIPKRLT
CETKKCEASQ VCIMVNGDAQ CIVPPAAAAA EIRINNFRFN RNSVQRNAKP AQQQRSAQHA
KPAQHGKPAQ HATQQQHAKP AQNAKPVQHN AQQQHAKPAQ HAAQQQHAKP AQHVAQQQQQ
QHAKPAAHTA AKPVQHNAQQ QHAKPAAHTA AKPVQHNAAQ QHAKPAAHGA KPAVNAARPV
QHNAAQQHAK PAAHTAAKPV QHNAAQQHAK PAAKPAKLTN AQKLQQEHQR QEALAKQQAR
IRQQNLVKQA AQKKQTSQRA ASKNQARPAT QKRN