ID   PSY1_YEAST              Reviewed;         127 AA.
AC   P36082;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Putative platinum sensitivity protein 1;
GN   Name=PSY1; OrderedLocusNames=YKL076C;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=8196765; DOI=10.1038/369371a0;
RA   Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V.,
RA   Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P.,
RA   Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L.,
RA   Daignan-Fornier B., del Rey F., Dion C., Domdey H., Duesterhoeft A.,
RA   Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H.,
RA   Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L.,
RA   Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M.,
RA   Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H.,
RA   Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J.,
RA   Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H.,
RA   Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J.,
RA   Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S.,
RA   Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F.,
RA   Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R.,
RA   Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W.,
RA   Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M.,
RA   Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C.,
RA   Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H.,
RA   Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L.,
RA   van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S.,
RA   von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M.,
RA   Becker I., Mewes H.-W.;
RT   "Complete DNA sequence of yeast chromosome XI.";
RL   Nature 369:371-378(1994).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   DISRUPTION PHENOTYPE.
RX   PubMed=15173006; DOI=10.1158/0008-5472.can-03-3113;
RA   Wu H.I., Brown J.A., Dorie M.J., Lazzeroni L., Brown J.M.;
RT   "Genome-wide identification of genes conferring resistance to the
RT   anticancer agents cisplatin, oxaliplatin, and mitomycin C.";
RL   Cancer Res. 64:3940-3948(2004).
RN   [4]
RP   DISRUPTION PHENOTYPE.
RX   PubMed=16121259; DOI=10.1371/journal.pgen.0010024;
RA   Lee W., St Onge R.P., Proctor M., Flaherty P., Jordan M.I., Arkin A.P.,
RA   Davis R.W., Nislow C., Giaever G.;
RT   "Genome-wide requirements for resistance to functionally distinct DNA-
RT   damaging agents.";
RL   PLoS Genet. 1:235-246(2005).
CC   -!- DISRUPTION PHENOTYPE: Leads to sensitivity the DNA-damaging agents
CC       cisplatin and oxaliplatin, but not to mitomycin C.
CC       {ECO:0000269|PubMed:15173006, ECO:0000269|PubMed:16121259}.
CC   -!- MISCELLANEOUS: Partially overlaps ORF YKL075C. Disruption phenotypes
CC       caused by deletion of this gene may also be a result of a defect in its
CC       overlapping gene. {ECO:0000305}.
CC   -!- CAUTION: Product of a dubious gene prediction unlikely to encode a
CC       functional protein. Because of that it is not part of the S.cerevisiae
CC       S288c complete/reference proteome set. {ECO:0000305|PubMed:24374639}.
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DR   EMBL; Z28075; CAA81912.1; -; Genomic_DNA.
DR   PIR; S37901; S37901.
DR   AlphaFoldDB; P36082; -.
DR   DIP; DIP-5091N; -.
DR   STRING; 4932.YKL076C; -.
DR   PaxDb; P36082; -.
DR   PRIDE; P36082; -.
DR   EnsemblFungi; YKL076C_mRNA; YKL076C; YKL076C.
DR   SGD; S000001559; PSY1.
DR   HOGENOM; CLU_1972179_0_0_1; -.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; IEA:UniProtKB-KW.
PE   5: Uncertain;
KW   DNA damage.
FT   CHAIN           1..127
FT                   /note="Putative platinum sensitivity protein 1"
FT                   /id="PRO_0000203169"
SQ   SEQUENCE   127 AA;  15159 MW;  768CEAEE01C3C9EC CRC64;
     MSCLLIVART TSGKLCWCWN PFSTTLKTSA EMMMKMKIMW TIARATKKAY LAGMWKEMIM
     WLSVILSLIQ GSLHWKKYVK LLQDRNGYKE KSKEKKQDPA FSFEPWRMLM HSLFIWYQIV
     VQMIYIC