ID   PT100_MOUSE             Reviewed;          76 AA.
AC   P0DJE0;
DT   22-FEB-2012, integrated into UniProtKB/Swiss-Prot.
DT   22-FEB-2012, sequence version 1.
DT   03-AUG-2022, entry version 54.
DE   RecName: Full=Protein PET100 homolog, mitochondrial;
DE   Flags: Precursor;
GN   Name=Pet100;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3]
RP   SUBCELLULAR LOCATION, AND IDENTIFICATION BY MASS SPECTROMETRY.
RX   PubMed=22356826; DOI=10.1186/gb-2012-13-2-r12;
RA   Szklarczyk R., Wanschers B.F., Cuypers T.D., Esseling J.J., Riemersma M.,
RA   van den Brand M.A., Gloerich J., Lasonder E., van den Heuvel L.P.,
RA   Nijtmans L.G., Huynen M.A.;
RT   "Iterative orthology prediction uncovers new mitochondrial proteins and
RT   identifies C12orf62 as the human ortholog of COX14, a protein involved in
RT   the assembly of cytochrome c oxidase.";
RL   Genome Biol. 13:RESEARCH0012.1-RESEARCH0012.14(2012).
CC   -!- FUNCTION: Plays a role in mitochondrial complex IV assembly.
CC       {ECO:0000250|UniProtKB:P0DJ07}.
CC   -!- SUBUNIT: Interacts with COX7A2. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}. Mitochondrion {ECO:0000269|PubMed:22356826}.
CC       Mitochondrion inner membrane {ECO:0000250|UniProtKB:P0DJ07}.
CC   -!- SIMILARITY: Belongs to the PET100 family. {ECO:0000305}.
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DR   EMBL; AK013674; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; AC170806; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS57601.1; -.
DR   RefSeq; NP_001182173.1; NM_001195244.1.
DR   AlphaFoldDB; P0DJE0; -.
DR   STRING; 10090.ENSMUSP00000137626; -.
DR   PhosphoSitePlus; P0DJE0; -.
DR   EPD; P0DJE0; -.
DR   MaxQB; P0DJE0; -.
DR   PaxDb; P0DJE0; -.
DR   PRIDE; P0DJE0; -.
DR   ProteomicsDB; 301869; -.
DR   Antibodypedia; 77906; 31 antibodies from 8 providers.
DR   Ensembl; ENSMUST00000156380; ENSMUSP00000137626; ENSMUSG00000087687.
DR   Ensembl; ENSMUST00000208950; ENSMUSP00000146433; ENSMUSG00000087687.
DR   GeneID; 100503890; -.
DR   KEGG; mmu:100503890; -.
DR   UCSC; uc009krz.2; mouse.
DR   CTD; 100131801; -.
DR   MGI; MGI:3615306; Pet100.
DR   VEuPathDB; HostDB:ENSMUSG00000087687; -.
DR   eggNOG; KOG4702; Eukaryota.
DR   GeneTree; ENSGT00390000016884; -.
DR   HOGENOM; CLU_194764_0_0_1; -.
DR   InParanoid; P0DJE0; -.
DR   OMA; QAEWFES; -.
DR   OrthoDB; 1562794at2759; -.
DR   PhylomeDB; P0DJE0; -.
DR   TreeFam; TF314727; -.
DR   BioGRID-ORCS; 100503890; 15 hits in 71 CRISPR screens.
DR   ChiTaRS; Pet100; mouse.
DR   PRO; PR:P0DJE0; -.
DR   Proteomes; UP000000589; Chromosome 8.
DR   RNAct; P0DJE0; protein.
DR   Bgee; ENSMUSG00000087687; Expressed in granulocyte and 251 other tissues.
DR   ExpressionAtlas; P0DJE0; baseline and differential.
DR   Genevisible; P0DJE0; MM.
DR   GO; GO:0031305; C:integral component of mitochondrial inner membrane; IBA:GO_Central.
DR   GO; GO:0051082; F:unfolded protein binding; IBA:GO_Central.
DR   GO; GO:0033617; P:mitochondrial cytochrome c oxidase assembly; IBA:GO_Central.
DR   InterPro; IPR018625; Pet100.
DR   PANTHER; PTHR33968; PTHR33968; 1.
DR   Pfam; PF09803; Pet100; 1.
PE   1: Evidence at protein level;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Transit peptide; Transmembrane; Transmembrane helix.
FT   TRANSIT         1..?
FT                   /note="Mitochondrion"
FT   CHAIN           ?..76
FT                   /note="Protein PET100 homolog, mitochondrial"
FT                   /id="PRO_0000415814"
FT   TRANSMEM        7..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   76 AA;  9410 MW;  CA8629FD3F728F94 CRC64;
     MGVKLEVFRM SLYLTFPVVM FWISNQAEWF EDYVVQRKRE LWPREKEGQR QELEEFKQKI
     RKQKEERLLQ AAQQSS