PT111_YEAST
ID PT111_YEAST Reviewed; 800 AA.
AC P08468; D6W083;
DT 01-AUG-1988, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 2.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=Protein PET111, mitochondrial;
DE Flags: Precursor;
GN Name=PET111; OrderedLocusNames=YMR257C; ORFNames=YM9920.11C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE.
RX PubMed=2823103; DOI=10.1128/mcb.7.8.2728-2734.1987;
RA Strick C.A., Fox T.D.;
RT "Saccharomyces cerevisiae positive regulatory gene PET111 encodes a
RT mitochondrial protein that is translated from an mRNA with a long 5'
RT leader.";
RL Mol. Cell. Biol. 7:2728-2734(1987).
RN [2]
RP SEQUENCE REVISION.
RA Strick C.A., Fox T.D.;
RL Submitted (AUG-1993) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169872;
RA Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T.,
RA Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K.,
RA Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P.,
RA Skelton J., Walsh S.V., Whitehead S., Barrell B.G.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII.";
RL Nature 387:90-93(1997).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [6]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
CC -!- FUNCTION: Required for translation of the mitochondrial gene for
CC cytochrome c oxidase subunit II (COX2).
CC -!- SUBCELLULAR LOCATION: Mitochondrion matrix.
CC -!- MISCELLANEOUS: Present with 538 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: To yeast YHR160C. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; M17143; AAA02906.1; -; Unassigned_DNA.
DR EMBL; Z48639; CAA88584.1; -; Genomic_DNA.
DR EMBL; AY693003; AAT93022.1; -; Genomic_DNA.
DR EMBL; BK006946; DAA10157.1; -; Genomic_DNA.
DR PIR; S53079; S53079.
DR RefSeq; NP_013984.1; NM_001182764.1.
DR AlphaFoldDB; P08468; -.
DR BioGRID; 35435; 181.
DR DIP; DIP-2800N; -.
DR IntAct; P08468; 6.
DR MINT; P08468; -.
DR STRING; 4932.YMR257C; -.
DR PaxDb; P08468; -.
DR PRIDE; P08468; -.
DR EnsemblFungi; YMR257C_mRNA; YMR257C; YMR257C.
DR GeneID; 855299; -.
DR KEGG; sce:YMR257C; -.
DR SGD; S000004870; PET111.
DR VEuPathDB; FungiDB:YMR257C; -.
DR eggNOG; ENOG502QVG0; Eukaryota.
DR HOGENOM; CLU_351657_0_0_1; -.
DR InParanoid; P08468; -.
DR OMA; MHESERF; -.
DR BioCyc; YEAST:G3O-32932-MON; -.
DR PRO; PR:P08468; -.
DR Proteomes; UP000002311; Chromosome XIII.
DR RNAct; P08468; protein.
DR GO; GO:0005743; C:mitochondrial inner membrane; IDA:SGD.
DR GO; GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; HDA:SGD.
DR GO; GO:0045182; F:translation regulator activity; IMP:SGD.
DR GO; GO:0033617; P:mitochondrial cytochrome c oxidase assembly; IMP:SGD.
DR GO; GO:0070131; P:positive regulation of mitochondrial translation; IMP:SGD.
PE 1: Evidence at protein level;
KW Activator; Mitochondrion; Reference proteome; Transit peptide;
KW Translation regulation.
FT TRANSIT 1..?
FT /note="Mitochondrion"
FT CHAIN ?..800
FT /note="Protein PET111, mitochondrial"
FT /id="PRO_0000022173"
FT CONFLICT 278
FT /note="D -> G (in Ref. 1; AAA02906)"
FT /evidence="ECO:0000305"
FT CONFLICT 709
FT /note="P -> S (in Ref. 1; AAA02906)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 800 AA; 94523 MW; C374DDE7D7C1BB48 CRC64;
MLQRRFISSS GIKRLLHRES NKVMHTVFFK VRYYSTELIK KKHKEDIEDW VKAQLKDSST
ISGVYESRNK LDWMDSITKS PSSLDILKNQ YNIVKDKDFG ILWKQKFESA DPDILMTIIS
LSTNQKVLFS IQQLLILINS LHFLKRDYDI GQIYTTYEQF TPLLASHTDK GTYGQFIEIM
LVVQHNLHHF DVCETLFAEY IKYCKVKPQM ISLGLNSFIR SNNTQLAVEF YTQAITNPDT
FPITEKQLFE FLRCMERYLD MSSMKHIFYL WLKVKCGDEQ SSSTNLPSFK TLAIIHRMLL
RFSNTDELND FLTNPVVLST GYTSSVQFEL IEFCHSLYCI KGDRTKSIDD SILMERVDKF
ITRLNNNIST RKELYMSVVQ AYVSTNNFEN LKVILEKIQR DNDISIDGSF HLCISRYFVN
TNQFEGLFKY YRSVVKTTDG KTRLRPAFIQ QLWSCAVNVY PMLAKEITND LLVTLKRSQY
SKCLTWVYTF LQENAHIHTR KINGGEDSSL SGFNAVDFER FEEFKKKVSH NDVYGAELVI
SNSLKEGIAP QFSFLYSVLA LCLRNSLTGL ARVVDVILRT RFRYIPLKVD ILWLKWEIIS
NYRSFEKLSA EHLKELEFKL KEFERVHQKE LSVQNYLQLT QICFHTRDFK YACYLISQAR
KNLDTSNNKQ WMMYYMTSLK LASRMHESER FSRILKDWNC NHRASLITPG CIRQIKGFMK
YFEKRPAYIS TAASIDNKEI KDRIDELVLR YVDYKYQGLE NMRKLTLFLK EWFDEEISLL
KLEQNERKMK LFEENKKEEE
