ID   PT122_LACK1             Reviewed;         312 AA.
AC   O13377;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Protein PET122, mitochondrial;
DE   Flags: Precursor;
GN   Name=PET122;
OS   Lachancea kluyveri (strain ATCC 58438 / CBS 3082 / BCRC 21498 / NBRC 1685 /
OS   JCM 7257 / NCYC 543 / NRRL Y-12651) (Yeast) (Saccharomyces kluyveri).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Lachancea.
OX   NCBI_TaxID=226302;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 58438 / CBS 3082 / BCRC 21498 / NBRC 1685 / JCM 7257 / NCYC 543
RC   / NRRL Y-12651;
RA   Costanzo M.C., Fox T.D.;
RL   Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for expression of the mitochondrial gene for
CC       cytochrome c oxidase subunit 3 (COX3). PET122 seems to work by directly
CC       interacting with the small ribosomal subunit to promote translation
CC       initiation on the COX3 mRNA (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF026396; AAB82603.1; -; Genomic_DNA.
DR   AlphaFoldDB; O13377; -.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:InterPro.
DR   GO; GO:0070131; P:positive regulation of mitochondrial translation; IEA:InterPro.
DR   InterPro; IPR008732; Pet122.
DR   Pfam; PF05476; PET122; 1.
DR   PIRSF; PIRSF003326; PET122; 1.
PE   3: Inferred from homology;
KW   Activator; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   Transit peptide; Translation regulation.
FT   TRANSIT         1..12
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000250"
FT   CHAIN           13..312
FT                   /note="Protein PET122, mitochondrial"
FT                   /id="PRO_0000022176"
SQ   SEQUENCE   312 AA;  37317 MW;  2D7BB64249530A58 CRC64;
     MIPTFRIQIR RYLNTEVKRR LYAQCLNRDF DSLLAEVKGI PVSEMEESFV TLYLMKSAQF
     GHVPSLDYLW HKYVMRHHMI MVNPSLLCDI GNIALQEGKL FIPEQLSSHF MKFYGSNNEY
     EQYRYELLRI QVESFAKGTM EKTSFREKWK VFLQDLDHTV ERDFQFSVRD FPHLTQALSG
     TDRELLLKML FSEGKISVCN NSSLPMLLNM ILLQEEFELE FKIKLFQNFY TIHRHLNYED
     TVTILFKNCK GNGYRSIELM EFVRGNKITT PHLAYKYFLQ SIIDSEYYFK AYDYMDLVKK
     YDGLLEQLRQ QE