ID   PT122_SACBA             Reviewed;         260 AA.
AC   O13374;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Protein PET122, mitochondrial;
DE   Flags: Precursor;
GN   Name=PET122;
OS   Saccharomyces bayanus (Yeast) (Saccharomyces uvarum x Saccharomyces
OS   eubayanus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=4931;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 76513 / CBS 380 / DSM 70412 / JCM 7258 / NBRC 1127 / NRRL
RC   Y-12624;
RX   PubMed=10757749; DOI=10.1093/genetics/154.3.999;
RA   Costanzo M.C., Bonnefoy N., Williams E.H., Clark-Walker G.D., Fox T.D.;
RT   "Highly diverged homologs of Saccharomyces cerevisiae mitochondrial mRNA-
RT   specific translational activators have orthologous functions in other
RT   budding yeasts.";
RL   Genetics 154:999-1012(2000).
CC   -!- FUNCTION: Required for expression of the mitochondrial gene for
CC       cytochrome c oxidase subunit 3 (COX3). PET122 seems to work by directly
CC       interacting with the small ribosomal subunit to promote translation
CC       initiation on the COX3 mRNA (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}.
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DR   EMBL; AF026394; AAB82600.1; -; Genomic_DNA.
DR   AlphaFoldDB; O13374; -.
DR   SMR; O13374; -.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:InterPro.
DR   GO; GO:0070131; P:positive regulation of mitochondrial translation; IEA:InterPro.
DR   InterPro; IPR008732; Pet122.
DR   Pfam; PF05476; PET122; 1.
DR   PIRSF; PIRSF003326; PET122; 1.
PE   3: Inferred from homology;
KW   Activator; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   Transit peptide; Translation regulation.
FT   TRANSIT         1..8
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000250"
FT   CHAIN           9..260
FT                   /note="Protein PET122, mitochondrial"
FT                   /id="PRO_0000022175"
SQ   SEQUENCE   260 AA;  29016 MW;  80AFEC2A7238262F CRC64;
     MLSITRRLMG TDVRSRLLLS SLNGDMPGAL LLLRQQQQAS MDVELLHTVL ARATALAHVE
     TIAYVWYHHV QPRRLAVEGR LLCDMAGVAL HQDKLFLPAQ FLQHHQTMGL GRGTSASASA
     EAQAVEFELR RVKVEAFARG TMHSTALSEK WKVFLQEMDT LPGQPPLRLR DFPQLARAVG
     VAAQLQQPQE QAAALALFGR QPLVVKNEWS LPLLLSAVLW HVPGPAQARR VLAEFRQCYR
     GLPLTDAEVV IKRRGFEIDT