ID   PT127_SCHPO             Reviewed;         524 AA.
AC   O74832;
DT   04-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 101.
DE   RecName: Full=mRNA degradation protein pet127, mitochondrial;
DE   Flags: Precursor;
GN   Name=pet127; ORFNames=SPCC1183.04c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
RN   [3]
RP   FUNCTION.
RX   PubMed=17292401; DOI=10.1016/j.jmb.2007.01.014;
RA   Wiesenberger G., Speer F., Haller G., Bonnefoy N., Schleiffer A.,
RA   Schafer B.;
RT   "RNA degradation in fission yeast mitochondria is stimulated by a member of
RT   a new family of proteins that are conserved in lower eukaryotes.";
RL   J. Mol. Biol. 367:681-691(2007).
CC   -!- FUNCTION: Required for the degradation of mRNA in mitochondria.
CC       {ECO:0000269|PubMed:17292401}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:16823372}.
CC   -!- SIMILARITY: Belongs to the PET127 family. {ECO:0000305}.
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DR   EMBL; CU329672; CAA21084.1; -; Genomic_DNA.
DR   PIR; T40844; T40844.
DR   RefSeq; NP_587887.1; NM_001022879.2.
DR   AlphaFoldDB; O74832; -.
DR   BioGRID; 275594; 2.
DR   STRING; 4896.SPCC1183.04c.1; -.
DR   iPTMnet; O74832; -.
DR   PaxDb; O74832; -.
DR   PRIDE; O74832; -.
DR   EnsemblFungi; SPCC1183.04c.1; SPCC1183.04c.1:pep; SPCC1183.04c.
DR   GeneID; 2539021; -.
DR   KEGG; spo:SPCC1183.04c; -.
DR   PomBase; SPCC1183.04c; pet127.
DR   VEuPathDB; FungiDB:SPCC1183.04c; -.
DR   eggNOG; ENOG502QPU6; Eukaryota.
DR   HOGENOM; CLU_003477_2_2_1; -.
DR   InParanoid; O74832; -.
DR   OMA; HEAYKFE; -.
DR   PhylomeDB; O74832; -.
DR   PRO; PR:O74832; -.
DR   Proteomes; UP000002485; Chromosome III.
DR   GO; GO:0005740; C:mitochondrial envelope; IGI:PomBase.
DR   GO; GO:0005759; C:mitochondrial matrix; ISO:PomBase.
DR   GO; GO:0005739; C:mitochondrion; HDA:PomBase.
DR   GO; GO:0000964; P:mitochondrial RNA 5'-end processing; ISO:PomBase.
DR   GO; GO:0000957; P:mitochondrial RNA catabolic process; IMP:PomBase.
DR   InterPro; IPR013943; Pet127.
DR   PANTHER; PTHR31014; PTHR31014; 1.
DR   Pfam; PF08634; Pet127; 1.
PE   3: Inferred from homology;
KW   Mitochondrion; Reference proteome; Transit peptide.
FT   TRANSIT         1..12
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           13..524
FT                   /note="mRNA degradation protein pet127, mitochondrial"
FT                   /id="PRO_0000352804"
SQ   SEQUENCE   524 AA;  60761 MW;  FB4021F1B1C04290 CRC64;
     MLIYKKKNFG RRSVYNLKKC LHKGFQINSC NIKAADNVLH SKASAFEKVN VVDKESIGNL
     QHHLDTVLPK KKFQFLRDPK TNDYKWDEYL SKILPVDKFN FGLLSKFRPP SEDEQLQKVA
     NSIGAEFVGS TSSLTGLMSQ LHFFISKWKF PNFSDLSKGF YISPNERNFT RLCRSASSVH
     ISYQNGLYCI DKDKSLTKEP SVNIILMNVG KSLETFFTVD KDQFLLYKKP PSSNGVLKPL
     KDVFQYGRCS SLLVRSQLDC YDKKIPESGV FDLKTRAVFG VRMNQTQPEL FKSYKLTHYY
     GNRISFEREY FDLIRSAFMK YSLQARLGYM QGVFVAYHNT SDIFGFQYIP LVAMDRAIHG
     SSEIGEAEFN LNLQLLEKIL QYATSIFPKR SFRVMLSTTE DVPNPPLKVY LEVADDKENR
     GFDLLDGQKN LEAKTVSPSN FCALEVCALQ FVNGVHKSVV KHLDEKETWS IKYHFRKPRD
     QDNLLRNYIR LRDDIKRRES KISNPPESLL HDYYACSEQY YKRN