PT191_YEAST
ID PT191_YEAST Reviewed; 108 AA.
AC Q02772; D6VWK7;
DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1993, sequence version 1.
DT 03-AUG-2022, entry version 164.
DE RecName: Full=Mitochondrial protein PET191;
GN Name=PET191; OrderedLocusNames=YJR034W; ORFNames=J1604;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8381337; DOI=10.1007/bf00336742;
RA McEwen J.E., Hong K.H., Park S., Preciado G.T.;
RT "Sequence and chromosomal localization of two PET genes required for
RT cytochrome c oxidase assembly in Saccharomyces cerevisiae.";
RL Curr. Genet. 23:9-14(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=7668047; DOI=10.1002/yea.320110809;
RA Huang M.-E., Chuat J.-C., Galibert F.;
RT "Analysis of a 42.5 kb DNA sequence of chromosome X reveals three tRNA
RT genes and 14 new open reading frames including a gene most probably
RT belonging to the family of ubiquitin-protein ligases.";
RL Yeast 11:775-781(1995).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=8641269; DOI=10.1002/j.1460-2075.1996.tb00557.x;
RA Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C.,
RA Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D.,
RA Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J.,
RA Heumann K., Hilger F., Hollenberg C.P., Huang M.-E., Jacq C.,
RA Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E.,
RA Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T.,
RA Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B.,
RA Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R.,
RA Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N.,
RA To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H.,
RA von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.;
RT "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X.";
RL EMBO J. 15:2031-2049(1996).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [6]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 74-108.
RX PubMed=7957102;
RA van Gool A.J., Verhage R., Swagemakers S.M.A., van de Putte P., Brouwer J.,
RA Troelstra C., Bootsma D., Hoeijmakers J.H.J.;
RT "RAD26, the functional S. cerevisiae homolog of the Cockayne syndrome B
RT gene ERCC6.";
RL EMBO J. 13:5361-5369(1994).
RN [7]
RP SUBCELLULAR LOCATION.
RX PubMed=11914276; DOI=10.1101/gad.970902;
RA Kumar A., Agarwal S., Heyman J.A., Matson S., Heidtman M., Piccirillo S.,
RA Umansky L., Drawid A., Jansen R., Liu Y., Cheung K.-H., Miller P.,
RA Gerstein M., Roeder G.S., Snyder M.;
RT "Subcellular localization of the yeast proteome.";
RL Genes Dev. 16:707-719(2002).
RN [8]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 76625 / YPH499;
RX PubMed=14576278; DOI=10.1073/pnas.2135385100;
RA Sickmann A., Reinders J., Wagner Y., Joppich C., Zahedi R.P., Meyer H.E.,
RA Schoenfisch B., Perschil I., Chacinska A., Guiard B., Rehling P.,
RA Pfanner N., Meisinger C.;
RT "The proteome of Saccharomyces cerevisiae mitochondria.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:13207-13212(2003).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION [LARGE SCALE
RP ANALYSIS].
RX PubMed=22984289; DOI=10.1074/mcp.m112.021105;
RA Voegtle F.N., Burkhart J.M., Rao S., Gerbeth C., Hinrichs J.,
RA Martinou J.C., Chacinska A., Sickmann A., Zahedi R.P., Meisinger C.;
RT "Intermembrane space proteome of yeast mitochondria.";
RL Mol. Cell. Proteomics 11:1840-1852(2012).
CC -!- FUNCTION: Involved in the assembly of cytochrome c oxidase.
CC -!- SUBCELLULAR LOCATION: Mitochondrion intermembrane space
CC {ECO:0000269|PubMed:11914276, ECO:0000269|PubMed:14576278,
CC ECO:0000269|PubMed:22984289}. Note=Imported into the mitochondria via
CC the mitochondrial MIA40-ERV1 machinery.
CC -!- DOMAIN: The twin Cx9C motifs are involved in the recognition by the
CC mitochondrial MIA40-ERV1 disulfide relay system and the subsequent
CC transfer of disulfide bonds by dithiol/disulfide exchange reactions to
CC the newly imported protein. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the PET191 family. {ECO:0000305}.
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DR EMBL; L06067; AAA34855.1; -; Genomic_DNA.
DR EMBL; X70013; CAA49613.1; -; Genomic_DNA.
DR EMBL; L36344; AAA88737.1; -; Genomic_DNA.
DR EMBL; Z49534; CAA89561.1; -; Genomic_DNA.
DR EMBL; AY558310; AAS56636.1; -; Genomic_DNA.
DR EMBL; X81635; CAA57289.1; -; Genomic_DNA.
DR EMBL; BK006943; DAA08823.1; -; Genomic_DNA.
DR PIR; S28924; S28924.
DR RefSeq; NP_012568.1; NM_001181692.1.
DR AlphaFoldDB; Q02772; -.
DR SMR; Q02772; -.
DR BioGRID; 33787; 88.
DR DIP; DIP-1619N; -.
DR IntAct; Q02772; 4.
DR MINT; Q02772; -.
DR STRING; 4932.YJR034W; -.
DR MaxQB; Q02772; -.
DR PaxDb; Q02772; -.
DR PRIDE; Q02772; -.
DR EnsemblFungi; YJR034W_mRNA; YJR034W; YJR034W.
DR GeneID; 853491; -.
DR KEGG; sce:YJR034W; -.
DR SGD; S000003795; PET191.
DR VEuPathDB; FungiDB:YJR034W; -.
DR eggNOG; KOG4114; Eukaryota.
DR HOGENOM; CLU_138069_1_0_1; -.
DR InParanoid; Q02772; -.
DR OMA; FLECKRG; -.
DR BioCyc; YEAST:G3O-31671-MON; -.
DR PRO; PR:Q02772; -.
DR Proteomes; UP000002311; Chromosome X.
DR RNAct; Q02772; protein.
DR GO; GO:0031305; C:integral component of mitochondrial inner membrane; IDA:SGD.
DR GO; GO:0005758; C:mitochondrial intermembrane space; IDA:SGD.
DR GO; GO:0005739; C:mitochondrion; HDA:SGD.
DR GO; GO:0033617; P:mitochondrial cytochrome c oxidase assembly; IMP:SGD.
DR InterPro; IPR018793; Cyt_c_oxidase_assmbl_Pet191.
DR PANTHER; PTHR28627; PTHR28627; 1.
DR Pfam; PF10203; Pet191_N; 1.
DR PROSITE; PS51808; CHCH; 1.
PE 1: Evidence at protein level;
KW Disulfide bond; Mitochondrion; Reference proteome.
FT CHAIN 1..108
FT /note="Mitochondrial protein PET191"
FT /id="PRO_0000022178"
FT DOMAIN 18..64
FT /note="CHCH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT MOTIF 21..32
FT /note="Cx10C motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT MOTIF 46..56
FT /note="Cx9C motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT DISULFID 21..56
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT DISULFID 32..46
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
SQ SEQUENCE 108 AA; 12394 MW; 9267E8AA02985147 CRC64;
MVASCKDQKK AVAICLQRSP CVMIERHNPQ ECLDNPELNK DLPELCIAQM KAFLDCKRGI
VDMTKRFTGN APLSTGKYDQ QYENLCKGKF DPREEMEKLK LLNSQQKD
