PT494_YEAST
ID PT494_YEAST Reviewed; 489 AA.
AC P07390; D6W1M0;
DT 01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 2.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=COX3 mRNA-specific translational activator PET494;
GN Name=PET494; OrderedLocusNames=YNR045W; ORFNames=N3436;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3010052; DOI=10.1007/bf00331654;
RA Costanzo M.C., Mueller P.P., Strick C.A., Fox T.D.;
RT "Primary structure of wild-type and mutant alleles of the PET494 gene of
RT Saccharomyces cerevisiae.";
RL Mol. Gen. Genet. 202:294-301(1986).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169873;
RA Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K.,
RA Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K.,
RA Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M.,
RA Beinhauer J.D., Boskovic J., Buitrago M.J., Bussereau F., Coster F.,
RA Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F.,
RA Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C.,
RA Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A.,
RA Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H.,
RA Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L.,
RA Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R.,
RA Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D.,
RA Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A.,
RA Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C.,
RA Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F.,
RA Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G.,
RA Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M.,
RA Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its
RT evolutionary implications.";
RL Nature 387:93-98(1997).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP SUBCELLULAR LOCATION.
RX PubMed=8389363; DOI=10.1016/s0021-9258(19)50261-7;
RA McMullin T.W., Fox T.D.;
RT "COX3 mRNA-specific translational activator proteins are associated with
RT the inner mitochondrial membrane in Saccharomyces cerevisiae.";
RL J. Biol. Chem. 268:11737-11741(1993).
RN [5]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
CC -!- FUNCTION: Required for the expression of the mitochondrial gene for
CC cytochrome c oxidase subunit III (COX3).
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000269|PubMed:8389363}; Peripheral membrane protein
CC {ECO:0000269|PubMed:8389363}.
CC -!- MISCELLANEOUS: Present with 450 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
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DR EMBL; K03520; AAA34857.1; -; Genomic_DNA.
DR EMBL; Z71660; CAA96326.1; -; Genomic_DNA.
DR EMBL; BK006947; DAA10586.1; -; Genomic_DNA.
DR PIR; S63376; RGBYP4.
DR RefSeq; NP_014443.3; NM_001183222.3.
DR AlphaFoldDB; P07390; -.
DR BioGRID; 35870; 178.
DR DIP; DIP-7463N; -.
DR IntAct; P07390; 10.
DR STRING; 4932.YNR045W; -.
DR PaxDb; P07390; -.
DR PRIDE; P07390; -.
DR EnsemblFungi; YNR045W_mRNA; YNR045W; YNR045W.
DR GeneID; 855781; -.
DR KEGG; sce:YNR045W; -.
DR SGD; S000005328; PET494.
DR VEuPathDB; FungiDB:YNR045W; -.
DR eggNOG; ENOG502S01Z; Eukaryota.
DR HOGENOM; CLU_042193_0_0_1; -.
DR InParanoid; P07390; -.
DR OMA; ILINDSM; -.
DR BioCyc; YEAST:G3O-33352-MON; -.
DR PRO; PR:P07390; -.
DR Proteomes; UP000002311; Chromosome XIV.
DR RNAct; P07390; protein.
DR GO; GO:0005743; C:mitochondrial inner membrane; IDA:SGD.
DR GO; GO:0005739; C:mitochondrion; HDA:SGD.
DR GO; GO:0045182; F:translation regulator activity; IMP:SGD.
DR GO; GO:0070131; P:positive regulation of mitochondrial translation; IMP:SGD.
PE 1: Evidence at protein level;
KW Activator; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW Reference proteome; Translation regulation.
FT CHAIN 1..489
FT /note="COX3 mRNA-specific translational activator PET494"
FT /id="PRO_0000097085"
FT CONFLICT 68
FT /note="F -> S (in Ref. 1; AAA34857)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 489 AA; 57488 MW; 9CFAA5A88A5242A3 CRC64;
MHLKKGKRSI STVWRLLWKR FYSVNSKTNM HFSRSRKKPV TNFTRTNGLL LSCNGDTFPY
LRTLWRYFNA PGNLMFVTTN IVAFMGIVTY NTLVTISSER AFEEQMMAAQ VSLAKQREEL
ETTALSLPRD IELRGEEDDI KWEQPDVAHV REDPLVEEQN AKLDTPIKQY TLGDLILNKR
ENVTDYDSQR AKASIFHMLY AYMLYRDVIQ PTTMTQNNNS EEWRREVELL TKGKEVQGTH
RRIDVFYDLW NKNFDKIVTS PEKVQNFQLP NWSKYPTILK FICTELHDNS LKTLGEFKQF
YGKVRSNEVK KLLGLWLYDH SFLFPHNIYD NRTEEDFYDI LINDSMQDNR IFQKYSSIVM
NPYNERTQLF FPNVNSPSVN KPVPSISLET YTRLLKGYIN LQETGCKYDY NDNIFKLISI
LKLNCFLQRN KKKHAGPTVR ILLPRDEDRS QILGTISQAE KRTCYQILSK NRDVVALLKR
ISDIQADSS
