ID   PTA1_SCHPO              Reviewed;         670 AA.
AC   Q10222; Q9UTR2;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   14-AUG-2001, sequence version 2.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=mRNA cleavage and polyadenylation specificity factor complex subunit pta1;
GN   Name=pta1; ORFNames=SPAC1071.01c, SPAC4H3.15c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   IDENTIFICATION IN THE CPF COMPLEX.
RX   PubMed=14617822; DOI=10.1074/mcp.m300081-mcp200;
RA   Roguev A., Shevchenko A., Schaft D., Thomas H., Stewart A.F.,
RA   Shevchenko A.;
RT   "A comparative analysis of an orthologous proteomic environment in the
RT   yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe.";
RL   Mol. Cell. Proteomics 3:125-132(2004).
RN   [3]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- FUNCTION: Component of the cleavage and polyadenylation factor (CPF)
CC       complex, which plays a key role in polyadenylation-dependent pre-mRNA
CC       3'-end formation and cooperates with cleavage factors including the
CC       CFIA complex and NAB4/CFIB.
CC   -!- SUBUNIT: Component of the cleavage and polyadenylation factor (CPF)
CC       complex, which is composed of cft1, cft2, ysh1, pta1, swd2, pfs2, dis2,
CC       yth1, ssu72, and fip1. {ECO:0000269|PubMed:14617822}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16823372}.
CC   -!- SIMILARITY: To yeast PTA1. {ECO:0000305}.
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DR   EMBL; CU329670; CAA93354.1; -; Genomic_DNA.
DR   PIR; T37483; T37483.
DR   RefSeq; NP_594351.2; NM_001019772.2.
DR   AlphaFoldDB; Q10222; -.
DR   SMR; Q10222; -.
DR   BioGRID; 279955; 8.
DR   STRING; 4896.SPAC1071.01c.1; -.
DR   MaxQB; Q10222; -.
DR   PaxDb; Q10222; -.
DR   PRIDE; Q10222; -.
DR   EnsemblFungi; SPAC1071.01c.1; SPAC1071.01c.1:pep; SPAC1071.01c.
DR   GeneID; 2543538; -.
DR   KEGG; spo:SPAC1071.01c; -.
DR   PomBase; SPAC1071.01c; pta1.
DR   VEuPathDB; FungiDB:SPAC1071.01c; -.
DR   eggNOG; KOG1895; Eukaryota.
DR   HOGENOM; CLU_021804_0_0_1; -.
DR   InParanoid; Q10222; -.
DR   OMA; AREMCLN; -.
DR   PhylomeDB; Q10222; -.
DR   PRO; PR:Q10222; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005847; C:mRNA cleavage and polyadenylation specificity factor complex; IDA:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0006379; P:mRNA cleavage; ISO:PomBase.
DR   GO; GO:0006378; P:mRNA polyadenylation; ISO:PomBase.
DR   GO; GO:0008033; P:tRNA processing; ISO:PomBase.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR021850; Symplekin/Pta1.
DR   InterPro; IPR032460; Symplekin/Pta1_N.
DR   PANTHER; PTHR15245:SF20; PTHR15245:SF20; 2.
DR   Pfam; PF11935; SYMPK_PTA1_N; 1.
PE   1: Evidence at protein level;
KW   mRNA processing; Nucleus; Reference proteome.
FT   CHAIN           1..670
FT                   /note="mRNA cleavage and polyadenylation specificity factor
FT                   complex subunit pta1"
FT                   /id="PRO_0000116838"
SQ   SEQUENCE   670 AA;  76233 MW;  13CC4CCE53FFB22F CRC64;
     MEVSETDEHL TRLNQARDIV KTDQSLFPEI VRNILSVANY SDIRYKKWMA NFLWFGFSSK
     NVKFEQKLDL AVTCLDTIVS LYAVDNEEVK KDVISCSCTI YPLVFLHCCT SPNDSSTWDT
     LTKLKNEIIN DFDKGNKPLL ISCIKFISCV ILTQVPGIRD PRLVTKSDVS LSKVPTHHPF
     INSNILRIEA NDLIEKIFSI LFSDSLNVLY ITSVLNILPV LVKRRKELAP KIIGSLLEFH
     LPNPKDEIEL SNESKLAIRC IEKNLKLILL HLAKSTGASS SSVEKIHAYL SGQIYHTKVD
     ESLKKRQYEG NISAASKRVK SSAVQSLVER MQPQLSSHDG LQNNPLISIF ASQTAINPLA
     NFDVTSIPVE VATEIVLTSL LKIDKNYFHQ QINMLRERVR SLSEPESLGL DQQVDEDEDE
     DYEPPEVDVQ TINASVEREA ARLEGSAPSN VVTDAFELPT PDSLSPMAIL EYFHGALSRL
     FDYAPQFERS IVSSSNLQNL TLENVDNTVW DKRHWAILLP RLCTRGLLNY QPVTSGEESG
     DASFTLSSFV RGQLFTYVAS NWRSSTNLIL NWLSEEWYND RLMLENPDCH EYEDVKWEGP
     QYEKWALKVI DSILPYLEAK DKVFMIFMSE LPELTDAIVD KIKFVCLDPD KTKLGFMTFQ
     YLIMFRLTCT