PTAB_ASPFU
ID PTAB_ASPFU Reviewed; 729 AA.
AC Q4X0N1;
DT 17-FEB-2016, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 1.
DT 25-MAY-2022, entry version 71.
DE RecName: Full=Transcriptional activator ptaB {ECO:0000305};
GN Name=ptaB {ECO:0000303|PubMed:26529322}; ORFNames=AFUA_2G12910;
OS Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS A1100) (Aspergillus fumigatus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA Barrell B.G., Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH SOMA, DISRUPTION
RP PHENOTYPE, AND FUNCTION.
RX PubMed=26529322; DOI=10.1371/journal.ppat.1005205;
RA Lin C.J., Sasse C., Gerke J., Valerius O., Irmer H., Frauendorf H.,
RA Heinekamp T., Strassburger M., Tran V.T., Herzog B., Braus-Stromeyer S.A.,
RA Braus G.H.;
RT "Transcription factor somA is required for adhesion, development and
RT virulence of the human pathogen Aspergillus fumigatus.";
RL PLoS Pathog. 11:E1005205-E1005205(2015).
CC -!- FUNCTION: Transcriptional regulator that forms a complex with somA to
CC control biofilm formation. {ECO:0000269|PubMed:26529322}.
CC -!- SUBUNIT: Interacts with somA. {ECO:0000269|PubMed:26529322}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q07684}.
CC -!- DISRUPTION PHENOTYPE: Leads to a reduced growth rate and a delayed
CC conidiation. {ECO:0000269|PubMed:26529322}.
CC -!- SIMILARITY: Belongs to the MFG1 family. {ECO:0000305}.
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DR EMBL; AAHF01000001; EAL93584.1; -; Genomic_DNA.
DR RefSeq; XP_755622.1; XM_750529.1.
DR AlphaFoldDB; Q4X0N1; -.
DR STRING; 746128.CADAFUBP00002792; -.
DR EnsemblFungi; EAL93584; EAL93584; AFUA_2G12910.
DR GeneID; 3512755; -.
DR KEGG; afm:AFUA_2G12910; -.
DR eggNOG; ENOG502S0PM; Eukaryota.
DR HOGENOM; CLU_009804_2_0_1; -.
DR InParanoid; Q4X0N1; -.
DR OMA; PGAGMVQ; -.
DR OrthoDB; 849287at2759; -.
DR Proteomes; UP000002530; Chromosome 2.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005667; C:transcription regulator complex; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR029005; LIM-bd/SEUSS.
DR PANTHER; PTHR10378; PTHR10378; 1.
DR Pfam; PF01803; LIM_bind; 1.
PE 1: Evidence at protein level;
KW Activator; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..729
FT /note="Transcriptional activator ptaB"
FT /id="PRO_0000435642"
FT REGION 1..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 207..341
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 505..538
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 614..729
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 216..238
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 239..289
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 304..341
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 661..686
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 729 AA; 78784 MW; 1077AD22355F09F7 CRC64;
MPQHPGLPPG HPMAPGQHPN AHPGAGMVQA VHPGVSAPGG PQVTQGGPMM GMPPGAGTTG
PGGPVQAHAL SHLGPAQAHL FQQPQFAQTF ANNPQLLQQH QHQQQILRQR MMFQQQQAAQ
QQQHAGLPVS LPNGTQGLNA AQLAAMQANS GMRPVNLQMH LQQMPHGPQN IQQQQQQLFA
MQQAQQAQQA HQAQQAQQAQ QAQQAAAAAA AAAAQPGQHT PQQRHAAHPQ NMHDAQSVTP
QPQPPPHQGS STPQSNPPQP PSSQPQQQPG AAPQPHPTPN PPPQQLPQAQ QPGQQPHQQP
QQPPQQQPQQ QQSQQGQPQG QQQQMTPQEA QMKAQQTQNQ AAMMMQQRMG MKGTSILALL
TFAEHLSNFT SRGEAQDLLY WQAFVDKFYS PVGVLRQGVY NPQAGSKQFE ISTPALARYY
LTQFTSGIRQ IQMLVEGARE RDSPNGGRIV ESRRTSFIYW FTNESQLFTN GTLIAHFDHN
NKIEMLDIVV MNHTEYLPRS QLQPLELSEQ KQSPKVSKNL GKRAQQKQAQ QAAPSLPESM
VTANGVPTAV MSFLEVAETI SHMQMLFQFS QQNPQFSPPE ALRNLVNTLQ SQNPNPGFMP
SPMNPAMQQG QNLRGPQMNG PNQFASPAMA HLGLPPQGSP HLSAHPSPAQ SHLAGPPGMV
QQGQMQPNVG QATSASASPQ VTNKRRRAST VKVENDDTGG PEVNGTATQG AAKVKASPRV
GGKRQKGTA
