ID   PTAFR_CAPHI             Reviewed;         342 AA.
AC   Q9GK76;
DT   10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Platelet-activating factor receptor;
DE            Short=PAF-R;
DE            Short=PAFr;
GN   Name=PTAFR {ECO:0000250|UniProtKB:P25105}; Synonyms=PAFR;
OS   Capra hircus (Goat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Capra.
OX   NCBI_TaxID=9925;
RN   [1] {ECO:0000312|EMBL:AAG39982.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11916258; DOI=10.3109/10425170109024998;
RA   Yang W., Diehl J.R., Roudebush W.E.;
RT   "Comparison of the coding sequence of the platelet-activating factor
RT   receptor gene in three species.";
RL   DNA Seq. 12:239-251(2001).
CC   -!- FUNCTION: Receptor for platelet activating factor, a chemotactic
CC       phospholipid mediator that possesses potent inflammatory, smooth-muscle
CC       contractile and hypotensive activity. Seems to mediate its action via a
CC       G protein that activates a phosphatidylinositol-calcium second
CC       messenger system (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with ARRB1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; AF302764; AAG39982.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9GK76; -.
DR   SMR; Q9GK76; -.
DR   STRING; 9925.ENSCHIP00000009023; -.
DR   Proteomes; UP000291000; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; NAS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004992; F:platelet activating factor receptor activity; IEA:InterPro.
DR   GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR002282; PAF_rcpt.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR01153; PAFRECEPTOR.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Chemotaxis; Disulfide bond; G-protein coupled receptor;
KW   Glycoprotein; Membrane; Receptor; Reference proteome; Transducer;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..342
FT                   /note="Platelet-activating factor receptor"
FT                   /id="PRO_0000070090"
FT   TOPO_DOM        1..16
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        17..38
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        39..54
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        55..74
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        75..91
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        92..113
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        114..133
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        134..155
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        156..184
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        185..205
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        206..233
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        234..254
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        255..276
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        277..296
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        297..342
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        4
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        169
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        90..173
FT                   /evidence="ECO:0000250|UniProtKB:P25105,
FT                   ECO:0000255|PROSITE-ProRule:PRU00521"
SQ   SEQUENCE   342 AA;  39612 MW;  39D9379AED60FD4E CRC64;
     MEPNNSFRVD SEFRYTLFPI FYSIVFVLGV IANSYVLWVF ARLYPSKKFN EIKIFMVNLT
     MADLLFLVTL PLWIVYYYNQ GDWILPKFLC NLAGCFFFIN TYCSVAFLAV ITYNRFQAVT
     RPIKTAQATT RKRGFLLSLI IWVSIVGAAS YFFVLDSTNS EPKKTGSGNI TRCFEHYEKG
     SIPVLIIHIF LVFSFFLVFL IILFCNLVII RTLLTQQVQM QRNAEVKRRA LWMVCTVLAV
     FVICFVPHHL VQLPWTLAEL GFQDTDFHQG INDAHQVTLC LLSTNCVLDP IIYCFLTKKF
     RKHLTEKLYS MRESRKCSRA TSETGTEVVV QLKDAPIKSL KY