PTAFR_CAVPO
ID PTAFR_CAVPO Reviewed; 342 AA.
AC P21556;
DT 01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1991, sequence version 2.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Platelet-activating factor receptor;
DE Short=PAF-R;
DE Short=PAFr;
GN Name=PTAFR;
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Lung;
RX PubMed=1846231; DOI=10.1038/349342a0;
RA Honda Z., Nakamura M., Miki I., Minami M., Watanabe T., Seyama Y.,
RA Okado H., Toh H., Ito K., Miyamoto T., Shimizu T.;
RT "Cloning by functional expression of platelet-activating factor receptor
RT from guinea-pig lung.";
RL Nature 349:342-346(1991).
CC -!- FUNCTION: Receptor for platelet activating factor, a chemotactic
CC phospholipid mediator that possesses potent inflammatory, smooth-muscle
CC contractile and hypotensive activity. Seems to mediate its action via a
CC G protein that activates a phosphatidylinositol-calcium second
CC messenger system.
CC -!- SUBUNIT: Interacts with ARRB1. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; X56736; CAA40060.1; -; mRNA.
DR PIR; S13638; S13638.
DR RefSeq; XP_005004316.1; XM_005004259.2.
DR RefSeq; XP_013009648.1; XM_013154194.1.
DR RefSeq; XP_013009649.1; XM_013154195.1.
DR AlphaFoldDB; P21556; -.
DR SMR; P21556; -.
DR STRING; 10141.ENSCPOP00000015534; -.
DR BindingDB; P21556; -.
DR ChEMBL; CHEMBL5136; -.
DR DrugCentral; P21556; -.
DR ABCD; P21556; 1 sequenced antibody.
DR Ensembl; ENSCPOT00000042353; ENSCPOP00000028935; ENSCPOG00000031748.
DR GeneID; 100720710; -.
DR KEGG; cpoc:100720710; -.
DR CTD; 5724; -.
DR eggNOG; ENOG502QTQI; Eukaryota.
DR GeneTree; ENSGT01050000244845; -.
DR HOGENOM; CLU_009579_8_2_1; -.
DR InParanoid; P21556; -.
DR OMA; AIHVIIC; -.
DR OrthoDB; 800525at2759; -.
DR TreeFam; TF350009; -.
DR PRO; PR:P21556; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000031748; Expressed in thyroid gland and 10 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0001530; F:lipopolysaccharide binding; IEA:Ensembl.
DR GO; GO:0001875; F:lipopolysaccharide immune receptor activity; IEA:Ensembl.
DR GO; GO:0005543; F:phospholipid binding; IEA:Ensembl.
DR GO; GO:0004992; F:platelet activating factor receptor activity; IEA:Ensembl.
DR GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.
DR GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
DR GO; GO:0032959; P:inositol trisphosphate biosynthetic process; IEA:Ensembl.
DR GO; GO:0048015; P:phosphatidylinositol-mediated signaling; IEA:Ensembl.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR002282; PAF_rcpt.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01153; PAFRECEPTOR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Chemotaxis; Disulfide bond; G-protein coupled receptor;
KW Glycoprotein; Membrane; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..342
FT /note="Platelet-activating factor receptor"
FT /id="PRO_0000070091"
FT TOPO_DOM 1..16
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 17..38
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 39..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..74
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 75..91
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 92..113
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 114..133
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 134..155
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 156..184
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 185..205
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 206..233
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 234..254
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 255..276
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 277..296
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 297..342
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 4
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 169
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 90..173
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 342 AA; 38984 MW; B6413B3A5C87B175 CRC64;
MELNSSSRVD SEFRYTLFPI VYSIIFVLGI IANGYVLWVF ARLYPSKKLN EIKIFMVNLT
VADLLFLITL PLWIVYYSNQ GNWFLPKFLC NLAGCLFFIN TYCSVAFLGV ITYNRFQAVK
YPIKTAQATT RKRGIALSLV IWVAIVAAAS YFLVMDSTNV VSNKAGSGNI TRCFEHYEKG
SKPVLIIHIC IVLGFFIVFL LILFCNLVII HTLLRQPVKQ QRNAEVRRRA LWMVCTVLAV
FVICFVPHHM VQLPWTLAEL GMWPSSNHQA INDAHQVTLC LLSTNCVLDP VIYCFLTKKF
RKHLSEKLNI MRSSQKCSRV TTDTGTEMAI PINHTPVNPI KN
